Values CatLog read from this paper
Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition
PMID 29891918doi:10.1038/s41467-018-04735-2Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 10 records (14 values) from this paper: 5,10-methylenetetrahydrofolate reductase (MTHFR) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 4 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolatefull length residues 1-656; baculovirus/Sf9-expressed | 40.7 | 0.0224 | 1.82 × 10³ calc. | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolaterecombinant; not phosphorylated | 51.4 | 0.0255 | 2.02 × 10³ calc. | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolatefull length residues 1-656; baculovirus/Sf9-expressed | 40.4 | 0.0225 | 1.80 × 10³ calc. | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolatefull length residues 1-656; baculovirus/Sf9-expressed | 39.9 | 0.0213 | 1.87 × 10³ calc. | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADHfull length residues 1-656; baculovirus/Sf9-expressed | — | 3.76 | — | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADHrecombinant; not phosphorylated | — | 2.16 | — | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHfull length residues 1-656; baculovirus/Sf9-expressed | — | 0.0355 | — | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHrecombinant; not phosphorylated | — | 0.0235 | — | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHfull length residues 1-656; baculovirus/Sf9-expressed | — | 0.0303 | — | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHfull length residues 1-656; baculovirus/Sf9-expressed | — | 0.0287 | — | pH 6.6 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |