EC 1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]
OxidoreductasesOpen in Browse
CatLog read 15 records for EC 1.5.1.20 from 2 papers, for 2 organisms. Names in these papers: 5,10-methylenetetrahydrofolate reductase (MTHFR), methylenetetrahydrofolate reductase (LmjMTHFR).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 41 records for EC 1.5.1.20 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.5.1.20 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition | Homo sapiens | 10 |
| Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence | Leishmania major | 5 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolatefull length residues 1-656; baculovirus/Sf9-expressed | 40.7 | 0.0224 | 1.82 × 10³ calc. | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolaterecombinant; not phosphorylated | 51.4 | 0.0255 | 2.02 × 10³ calc. | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolatefull length residues 1-656; baculovirus/Sf9-expressed | 40.4 | 0.0225 | 1.80 × 10³ calc. | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | 5,10-methylenetetrahydrofolatefull length residues 1-656; baculovirus/Sf9-expressed | 39.9 | 0.0213 | 1.87 × 10³ calc. | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), 5,10-methylenetetrahydrofolate |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADHfull length residues 1-656; baculovirus/Sf9-expressed | — | 3.76 | — | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADHrecombinant; not phosphorylated | — | 2.16 | — | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHfull length residues 1-656; baculovirus/Sf9-expressed | — | 0.0355 | — | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHrecombinant; not phosphorylated | — | 0.0235 | — | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHfull length residues 1-656; baculovirus/Sf9-expressed | — | 0.0303 | — | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |
| 5,10-methylenetetrahydrofolate reductase (MTHFR) | Homo sapiens | NADPHfull length residues 1-656; baculovirus/Sf9-expressed | — | 0.0287 | — | pH 6.6 | PMID 29891918 | Open record: 5,10-methylenetetrahydrofolate reductase (MTHFR), NADPH |
| methylenetetrahydrofolate reductase (LmjMTHFR) | Leishmania major | (6R)-5,10-methylenetetrahydrofolate | 11.1 | 0.015 | 740 | pH 7.2, 37 °C | PMID 17032644 | Open record: methylenetetrahydrofolate reductase (LmjMTHFR), (6R)-5,10-methylenetetrahydrofolate |
| methylenetetrahydrofolate reductase (LmjMTHFR) | Leishmania major | NADH50 mM sodium phosphate pH 7.2 | 52 | 0.053 | 980 | pH 7.2, 37 °C | PMID 17032644 | Open record: methylenetetrahydrofolate reductase (LmjMTHFR), NADH |
| methylenetetrahydrofolate reductase (LmjMTHFR) | Leishmania major | NADH50 mM Tris-Cl pH 7.2 | 87 | 0.09 | 970 | pH 7.2, 37 °C | PMID 17032644 | Open record: methylenetetrahydrofolate reductase (LmjMTHFR), NADH |
| methylenetetrahydrofolate reductase (LmjMTHFR) | Leishmania major | NADPH50 mM sodium phosphate pH 7.2 | 74 | 0.09 | 820 | pH 7.2, 37 °C | PMID 17032644 | Open record: methylenetetrahydrofolate reductase (LmjMTHFR), NADPH |
| methylenetetrahydrofolate reductase (LmjMTHFR) | Leishmania major | NADPH50 mM Tris-Cl pH 7.2 | 140 | 0.17 | 820 | pH 7.2, 37 °C | PMID 17032644 | Open record: methylenetetrahydrofolate reductase (LmjMTHFR), NADPH |