CatLogenzyme kinetics catalog

Values CatLog read from this paper

Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer

PMID 31201273doi:10.1074/jbc.ra119.009251Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 8 records (24 values) from this paper: guanylate kinase (hGMPK) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 2.7.4.8

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
guanylate kinase (hGMPK)Homo sapiensguanosine 5'-monophosphate58.50.02072.8 × 10³pH 7.5, 25 °COpen
guanylate kinase (hGMPK)variant G3AHomo sapiensguanosine 5'-monophosphate184.40.07832.4 × 10³pH 7.5, 25 °COpen
guanylate kinase (hGMPK)variant R116QHomo sapiensguanosine 5'-monophosphate1270.05432.3 × 10³pH 7.5, 25 °COpen
guanylate kinase (hGMPK)variant R96HHomo sapiensguanosine 5'-monophosphate100.60.02963.4 × 10³pH 7.5, 25 °COpen
guanylate kinase (hGMPK)variant S121FHomo sapiensguanosine 5'-monophosphate101.40.04862.1 × 10³pH 7.5, 25 °COpen
guanylate kinase (hGMPK)variant S186YHomo sapiensguanosine 5'-monophosphate96.50.03682.6 × 10³pH 7.5, 25 °COpen
guanylate kinase (hGMPK)variant S2LHomo sapiensguanosine 5'-monophosphate77.70.03152.5 × 10³pH 7.5, 25 °COpen
guanylate kinase (hGMPK)variant V91MHomo sapiensguanosine 5'-monophosphate132.20.05472.4 × 10³pH 7.5, 25 °COpen