CatLogenzyme kinetics catalog

Values CatLog read from this paper

Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase

PMID 33283177doi:10.1016/j.isci.2020.101849Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 6 records (18 values) from this paper: SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/NSP7/NSP8 complex from Severe acute respiratory syndrome coronavirus 2.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 2.7.7.48

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/NSP7/NSP8 complexSevere acute respiratory syndrome coronavirus 2ATP2400.32740pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/NSP7/NSP8 complexSevere acute respiratory syndrome coronavirus 2Remdesivir 5'-triphosphatefirst RTP incorporation680.0531.29 × 10³pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/NSP7/NSP8 complexSevere acute respiratory syndrome coronavirus 2Remdesivir 5'-triphosphatesecond RTP incorporation3.620.019190pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/NSP7/NSP8 complexSevere acute respiratory syndrome coronavirus 2Remdesivir 5'-triphosphatethird RTP incorporation3.760.021180pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/NSP7/NSP8 complexSevere acute respiratory syndrome coronavirus 2UTPfirst UTP incorporation3080.132.3 × 10³pH 7, 37 °COpen
SARS-CoV-2 RNA-dependent RNA polymerase (RdRp), NSP12/NSP7/NSP8 complexSevere acute respiratory syndrome coronavirus 2UTPsecond UTP incorporation6800.41.7 × 10³pH 7, 37 °COpen