Values CatLog read from this paper
Disease variants of human Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)
PMID 33771508doi:10.1016/j.abb.2021.108852Open in Browse
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CatLog read 18 records (54 values) from this paper: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM (Table 1 footnote e); cosubstrate NADH | 61.3 | 1.509 | 41 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADPH fixed at 500 μM (Table 1 footnote e); Table 1 | 26 | 0.994 | 26 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM; cosubstrate NADH; Table 3 | 52.6 | 2.126 | 24.7 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM; cosubstrate NADH; Table 3 | 34.5 | 1.627 | 21.2 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM; cosubstrate NADH; Table 3 | 42.3 | 3.149 | 13.4 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic; Table 1 footnote f) | 47.9 | 0.298 | 161 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic); Table 2 | 37.3 | 0.259 | 144 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic); Table 2 | 26.5 | 0.209 | 127 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic); Table 2 | 19.1 | 0.211 | 90.5 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotide phosphate | 24 | 0.216 | 111 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide phosphate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH; cosubstrate NADH | 0.08 | 0.317 | 0.25 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADPH; cosubstrate NADPH | 0.13 | 0.334 | 0.4 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | reduced nicotinamide adenine dinucleotide | 0.015 | 0.034 | 0.44 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | reduced nicotinamide adenine dinucleotide phosphate | 1.5 | 0.537 | 2.8 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, reduced nicotinamide adenine dinucleotide phosphate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH; cosubstrate NADH | 3.2 | 1.315 | 2.4 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADPH; cosubstrate NADPH | 3.1 | 1.499 | 2.1 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | reduced nicotinamide adenine dinucleotide | 5.9 | 0.953 | 6.2 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | reduced nicotinamide adenine dinucleotide phosphate | 1.8 | 0.119 | 15 | pH 7.5, 37 °C | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, reduced nicotinamide adenine dinucleotide phosphate |