EC 1.5.1.2: pyrroline-5-carboxylate reductase
OxidoreductasesOpen in Browse
CatLog read 40 records for EC 1.5.1.2 from 5 papers, for 3 organisms. Names in these papers: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), Delta1-pyrroline-5-carboxylate reductase (ProC), pyrroline-5-carboxylate reductase (P5CR), pyrroline-5-carboxylate reductase 1 (PYCR1).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 84 records for EC 1.5.1.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.5.1.2 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Disease variants of human Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | 18 |
| The Substrate Versatility of Δ1-Pyrroline-5-carboxylate Reductase (ProC) from Escherichia coli | Escherichia coli | 9 |
| Crystal structure of human pyrroline-5-carboxylate reductase | Homo sapiens | 6 |
| Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1 | Homo sapiens | 6 |
| Molecular annotation of ketol-acid reductoisomerases from Streptomyces reveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity | Streptomyces coelicolor | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | (S)-1,3-thiazinane-4-carboxylate | 0.14 | 2.5 | 0.056 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), (S)-1,3-thiazinane-4-carboxylate |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | 3,4-dehydro-L-proline | 9.1 | 0.54 | 16.9 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), 3,4-dehydro-L-proline |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | cis-4-hydroxy-L-proline | 1.5 | 57 | 0.027 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), cis-4-hydroxy-L-proline |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | L-pipecolate | 0.6 | 4.4 | 0.14 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), L-pipecolate |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | L-prolinamide | 4.3 | 5.2 | 0.83 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), L-prolinamide |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | L-prolineL-Pro/analog oxidation direction (NADPH formation at 340 nm) | 2.8 | 0.33 | 8.5 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), L-proline |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | L-prolineL-Pro oxidation direction (NADH formation at 340 nm) | 13 | 20 | 0.65 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), L-proline |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | L-thiazolidine-4-carboxylate | 4.7 | 2.3 | 2.1 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), L-thiazolidine-4-carboxylate |
| Delta1-pyrroline-5-carboxylate reductase (ProC) | Escherichia coli | trans-4-hydroxy-L-proline | 1.1 | 20 | 0.055 | pH 10, 27 °C | PMID 41683478 | Open record: Delta1-pyrroline-5-carboxylate reductase (ProC), trans-4-hydroxy-L-proline |
| pyrroline-5-carboxylate reductase (P5CR) | Homo sapiens | L-thiazolidine-4-carboxylic acid | 55 | 1.26 | 44 calc. | pH 9 | PMID 16730026 | Open record: pyrroline-5-carboxylate reductase (P5CR), L-thiazolidine-4-carboxylic acid |
| pyrroline-5-carboxylate reductase (P5CR) | Homo sapiens | NAD+ | — | 0.151 | — | pH 9 | PMID 16730026 | Open record: pyrroline-5-carboxylate reductase (P5CR), NAD+ |
| pyrroline-5-carboxylate reductase (P5CR) | Homo sapiens | NADP+ | — | 3.06 | — | pH 9 | PMID 16730026 | Open record: pyrroline-5-carboxylate reductase (P5CR), NADP+ |
| pyrroline-5-carboxylate reductase (P5CR)variant E221A | Homo sapiens | L-thiazolidine-4-carboxylic acid | 13 | 0.73 | 18 calc. | pH 9 | PMID 16730026 | Open record: pyrroline-5-carboxylate reductase (P5CR) variant E221A, L-thiazolidine-4-carboxylic acid |
| pyrroline-5-carboxylate reductase (P5CR)variant E221A | Homo sapiens | NAD+ | — | 0.235 | — | pH 9 | PMID 16730026 | Open record: pyrroline-5-carboxylate reductase (P5CR) variant E221A, NAD+ |
| pyrroline-5-carboxylate reductase (P5CR)variant E221A | Homo sapiens | NADP+ | — | 0.48 | — | pH 9 | PMID 16730026 | Open record: pyrroline-5-carboxylate reductase (P5CR) variant E221A, NADP+ |
| pyrroline-5-carboxylate reductase (P5CR) | Streptomyces coelicolor | pyrroline-5-carboxylate | — | — | 0.601 | pH 8, 25 °C | PMID 25296650 | Open record: pyrroline-5-carboxylate reductase (P5CR), pyrroline-5-carboxylate |
| pyrroline-5-carboxylate reductase 1 (PYCR1) | Homo sapiens | L-delta1-pyrroline-5-carboxylate | 31 | 0.667 | 47 | pH 7.5, 37 °C | PMID 28258219 | Open record: pyrroline-5-carboxylate reductase 1 (PYCR1), L-delta1-pyrroline-5-carboxylate |
| pyrroline-5-carboxylate reductase 1 (PYCR1) | Homo sapiens | NADH | 218 | 0.07 | 3.1 × 10³ | pH 7.5, 37 °C | PMID 28258219 | Open record: pyrroline-5-carboxylate reductase 1 (PYCR1), NADH |
| pyrroline-5-carboxylate reductase 1 (PYCR1) | Homo sapiens | NADPH | 74 | 0.283 | 260 | pH 7.5, 37 °C | PMID 28258219 | Open record: pyrroline-5-carboxylate reductase 1 (PYCR1), NADPH |
| pyrroline-5-carboxylate reductase 1 (PYCR1)variant T238A | Homo sapiens | L-delta1-pyrroline-5-carboxylate | 14 | 2.887 | 5 | pH 7.5, 37 °C | PMID 28258219 | Open record: pyrroline-5-carboxylate reductase 1 (PYCR1) variant T238A, L-delta1-pyrroline-5-carboxylate |
| pyrroline-5-carboxylate reductase 1 (PYCR1)variant T238A | Homo sapiens | L-delta1-pyrroline-5-carboxylateestimated kcat/Km | — | — | 16.7 | pH 7.5, 37 °C | PMID 28258219 | Open record: pyrroline-5-carboxylate reductase 1 (PYCR1) variant T238A, L-delta1-pyrroline-5-carboxylate |
| pyrroline-5-carboxylate reductase 1 (PYCR1)variant T238A | Homo sapiens | NADPH | 23 | 0.159 | 140 | pH 7.5, 37 °C | PMID 28258219 | Open record: pyrroline-5-carboxylate reductase 1 (PYCR1) variant T238A, NADPH |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM (Table 1 footnote e); cosubstrate NADH | 61.3 | 1.509 | 41 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADPH fixed at 500 μM (Table 1 footnote e); Table 1 | 26 | 0.994 | 26 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM; cosubstrate NADH; Table 3 | 52.6 | 2.126 | 24.7 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM; cosubstrate NADH; Table 3 | 34.5 | 1.627 | 21.2 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH fixed at 500 μM; cosubstrate NADH; Table 3 | 42.3 | 3.149 | 13.4 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic; Table 1 footnote f) | 47.9 | 0.298 | 161 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic); Table 2 | 37.3 | 0.259 | 144 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic); Table 2 | 26.5 | 0.209 | 127 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotideDL-P5C fixed at 5000 μM (racemic); Table 2 | 19.1 | 0.211 | 90.5 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) | Homo sapiens | reduced nicotinamide adenine dinucleotide phosphate | 24 | 0.216 | 111 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2), reduced nicotinamide adenine dinucleotide phosphate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH; cosubstrate NADH | 0.08 | 0.317 | 0.25 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADPH; cosubstrate NADPH | 0.13 | 0.334 | 0.4 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | reduced nicotinamide adenine dinucleotide | 0.015 | 0.034 | 0.44 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R119C | Homo sapiens | reduced nicotinamide adenine dinucleotide phosphate | 1.5 | 0.537 | 2.8 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R119C, reduced nicotinamide adenine dinucleotide phosphate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADH; cosubstrate NADH | 3.2 | 1.315 | 2.4 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | L-Δ1-pyrroline-5-carboxylateNADPH; cosubstrate NADPH | 3.1 | 1.499 | 2.1 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, L-Δ1-pyrroline-5-carboxylate |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | reduced nicotinamide adenine dinucleotide | 5.9 | 0.953 | 6.2 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, reduced nicotinamide adenine dinucleotide |
| Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)variant R251C | Homo sapiens | reduced nicotinamide adenine dinucleotide phosphate | 1.8 | 0.119 | 15 | pH 7.5, 37 °C | PMID 33771508 | Open record: Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2) variant R251C, reduced nicotinamide adenine dinucleotide phosphate |