Values CatLog read from this paper
Modifications of the Prothrombin Active Site S4 Subpocket Confer Resistance to Dabigatran
PMID 39938570doi:10.1055/a-2537-6037Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 8 records (24 values) from this paper: thrombin from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| thrombin | Homo sapiens | H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide | 0.28 | 0.034 | 8.2 | pH 7.5 | Open record: thrombin, H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide |
| thrombin | Homo sapiens | N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin | 0.23 | 0.082 | 2.8 | pH 7.5 | Open record: thrombin, N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin |
| thrombinvariant I174A | Homo sapiens | H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide | 0.35 | 0.043 | 8.2 | pH 7.5 | Open record: thrombin variant I174A, H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide |
| thrombinvariant I174A | Homo sapiens | N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin | 0.13 | 0.163 | 0.83 | pH 7.5 | Open record: thrombin variant I174A, N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin |
| thrombinvariant I174F | Homo sapiens | H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide | 0.4 | 0.05 | 7.8 | pH 7.5 | Open record: thrombin variant I174F, H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide |
| thrombinvariant I174F | Homo sapiens | N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin | 0.1 | 0.153 | 0.67 | pH 7.5 | Open record: thrombin variant I174F, N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin |
| thrombinvariant KL3 | Homo sapiens | H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide | 0.58 | 0.082 | 7.2 | pH 7.5 | Open record: thrombin variant KL3, H-D-phenylalanyl-L-pipecolyl-L-arginine p-nitroanilide |
| thrombinvariant KL3 | Homo sapiens | N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin | 0.083 | 0.188 | 0.5 | pH 7.5 | Open record: thrombin variant KL3, N-benzyloxycarbonyl-glycyl-glycyl-L-arginine 7-amido-4-methylcoumarin |