Values CatLog read from this paper
TAS3351 is a brain penetrable EGFR-TKI that overcomes T790M and C797S resistant mutations
PMID 41882274doi:10.1038/s43856-026-01546-1Open in Browse
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CatLog read 9 records (27 values) from this paper: EGFR (epidermal growth factor receptor) tyrosine kinase from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| EGFR (epidermal growth factor receptor) tyrosine kinase | Homo sapiens | adenosine 5'-triphosphate | 3.97 | 0.0297 | 134 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del | Homo sapiens | adenosine 5'-triphosphate | 3.23 | 0.267 | 12.1 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del/C797S | Homo sapiens | adenosine 5'-triphosphate | 6.42 | 0.314 | 20.5 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del/C797S, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del/T790M | Homo sapiens | adenosine 5'-triphosphate | 5.71 | 0.105 | 54.5 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del/T790M, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del/T790M/C797S | Homo sapiens | adenosine 5'-triphosphate | 7.61 | 0.116 | 65.9 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del/T790M/C797S, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R | Homo sapiens | adenosine 5'-triphosphate | 7.55 | 0.395 | 19.1 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R/C797S | Homo sapiens | adenosine 5'-triphosphate | 11.3 | 0.515 | 22 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R/C797S, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R/T790M | Homo sapiens | adenosine 5'-triphosphate | 2.89 | 0.072 | 40.1 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R/T790M, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R/T790M/C797S | Homo sapiens | adenosine 5'-triphosphate | 2.07 | 0.0673 | 30.7 | 30 °C | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R/T790M/C797S, adenosine 5'-triphosphate |