EC 2.7.10.1: receptor protein-tyrosine kinase
TransferasesOpen in Browse
CatLog read 25 records for EC 2.7.10.1 from 3 papers, for 1 organism. Names in these papers: EGFR (epidermal growth factor receptor) tyrosine kinase, Epidermal growth factor receptor (EGFR) kinase, Muscle-Specific Kinase (MuSK) tyrosine kinase domain.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 14 records for EC 2.7.10.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.10.1 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| The role of kinase domain dimerization in EGFR activation | Homo sapiens | 9 |
| TAS3351 is a brain penetrable EGFR-TKI that overcomes T790M and C797S resistant mutations | Homo sapiens | 9 |
| An S752D activation loop mutation dynamically primes Muscle-Specific Kinase for activation | Homo sapiens | 7 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| EGFR (epidermal growth factor receptor) tyrosine kinase | Homo sapiens | adenosine 5'-triphosphate | 3.97 | 0.0297 | 134 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del | Homo sapiens | adenosine 5'-triphosphate | 3.23 | 0.267 | 12.1 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del/C797S | Homo sapiens | adenosine 5'-triphosphate | 6.42 | 0.314 | 20.5 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del/C797S, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del/T790M | Homo sapiens | adenosine 5'-triphosphate | 5.71 | 0.105 | 54.5 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del/T790M, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant Ex19del/T790M/C797S | Homo sapiens | adenosine 5'-triphosphate | 7.61 | 0.116 | 65.9 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant Ex19del/T790M/C797S, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R | Homo sapiens | adenosine 5'-triphosphate | 7.55 | 0.395 | 19.1 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R/C797S | Homo sapiens | adenosine 5'-triphosphate | 11.3 | 0.515 | 22 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R/C797S, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R/T790M | Homo sapiens | adenosine 5'-triphosphate | 2.89 | 0.072 | 40.1 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R/T790M, adenosine 5'-triphosphate |
| EGFR (epidermal growth factor receptor) tyrosine kinasevariant L858R/T790M/C797S | Homo sapiens | adenosine 5'-triphosphate | 2.07 | 0.0673 | 30.7 | 30 °C | PMID 41882274 | Open record: EGFR (epidermal growth factor receptor) tyrosine kinase variant L858R/T790M/C797S, adenosine 5'-triphosphate |
| Epidermal growth factor receptor (EGFR) kinasevariant K708C/C781S | Homo sapiens | AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) | 0.19 | — | — | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant K708C/C781S, AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) |
| Epidermal growth factor receptor (EGFR) kinasevariant K929C | Homo sapiens | AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) | 0.3 | — | — | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant K929C, AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) |
| Epidermal growth factor receptor (EGFR) kinasevariant K929C | Homo sapiens | AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) | 0.18 | — | — | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant K929C, AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) |
| Epidermal growth factor receptor (EGFR) kinasevariant KDD ICRΔC | Homo sapiens | adenosine 5'-triphosphate | — | 0.023 | 987 | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant KDD ICRΔC, adenosine 5'-triphosphate |
| Epidermal growth factor receptor (EGFR) kinasevariant KDD ICRΔC | Homo sapiens | AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) | 22.7 | 0.03 | 757 | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant KDD ICRΔC, AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) |
| Epidermal growth factor receptor (EGFR) kinasevariant KDD ICRΔC (L858’R) | Homo sapiens | adenosine 5'-triphosphate | — | 0.084 | 498 | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant KDD ICRΔC (L858’R), adenosine 5'-triphosphate |
| Epidermal growth factor receptor (EGFR) kinasevariant KDD ICRΔC (L858’R) | Homo sapiens | AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) | 41.8 | 0.048 | 871 | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant KDD ICRΔC (L858’R), AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) |
| Epidermal growth factor receptor (EGFR) kinasevariant S-S dimer | Homo sapiens | adenosine 5'-triphosphate | — | 0.082 | 274 | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant S-S dimer, adenosine 5'-triphosphate |
| Epidermal growth factor receptor (EGFR) kinasevariant S-S dimer | Homo sapiens | AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) | 22.5 | 0.032 | 703 | pH 7.5, 30 °C | PMID 41421344 | Open record: Epidermal growth factor receptor (EGFR) kinase variant S-S dimer, AQT0001 peptide (AssayQuant PhosphoSens EGFR Sox-based peptide sensor) |
| Muscle-Specific Kinase (MuSK) tyrosine kinase domain | Homo sapiens | Aqt0031 peptide | 0.001 | 0.815 | 7 × 10⁻⁴ | pH 7.5, 30 °C | PMID 42240394 | Open record: Muscle-Specific Kinase (MuSK) tyrosine kinase domain, Aqt0031 peptide |
| Muscle-Specific Kinase (MuSK) tyrosine kinase domainvariant S752D | Homo sapiens | Aqt0031 peptide | 0.075 | 0.2737 | 0.16 | pH 7.5, 30 °C | PMID 42240394 | Open record: Muscle-Specific Kinase (MuSK) tyrosine kinase domain variant S752D, Aqt0031 peptide |
| Muscle-Specific Kinase (MuSK) tyrosine kinase domainvariant S752D | Homo sapiens | ATP | — | 1.369 | 0.066 | pH 7.5, 30 °C | PMID 42240394 | Open record: Muscle-Specific Kinase (MuSK) tyrosine kinase domain variant S752D, ATP |
| Muscle-Specific Kinase (MuSK) tyrosine kinase domainvariant S752D (pY-S752D, in vitro autophosphorylated) | Homo sapiens | Aqt0031 peptide | 0.771 | 0.6335 | 3 | pH 7.5, 30 °C | PMID 42240394 | Open record: Muscle-Specific Kinase (MuSK) tyrosine kinase domain variant S752D (pY-S752D, in vitro autophosphorylated), Aqt0031 peptide |
| Muscle-Specific Kinase (MuSK) tyrosine kinase domainvariant S752D (pY-S752D, in vitro autophosphorylated) | Homo sapiens | ATP | — | 0.0895 | 8.7 | pH 7.5, 30 °C | PMID 42240394 | Open record: Muscle-Specific Kinase (MuSK) tyrosine kinase domain variant S752D (pY-S752D, in vitro autophosphorylated), ATP |
| Muscle-Specific Kinase (MuSK) tyrosine kinase domainvariant pY-WT (in vitro autophosphorylated wild type) | Homo sapiens | Aqt0031 peptide | 0.395 | 0.4373 | 0.94 | pH 7.5, 30 °C | PMID 42240394 | Open record: Muscle-Specific Kinase (MuSK) tyrosine kinase domain variant pY-WT (in vitro autophosphorylated wild type), Aqt0031 peptide |
| Muscle-Specific Kinase (MuSK) tyrosine kinase domainvariant pY-WT (in vitro autophosphorylated wild type) | Homo sapiens | ATP | — | 0.152 | 2.7 | pH 7.5, 30 °C | PMID 42240394 | Open record: Muscle-Specific Kinase (MuSK) tyrosine kinase domain variant pY-WT (in vitro autophosphorylated wild type), ATP |