Values CatLog read from this paper
The seven human coronavirus main proteases exhibit differential modulation of NF-κB suppression via TAB1 cleavage
PMID 42168570doi:10.1038/s42003-026-10225-9Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 14 records (42 values) from this paper: HCoV-229E Mpro, HCoV-HKU1 Mpro, HCoV-NL63 Mpro and 4 more from human coronavirus 229E, human coronavirus HKU1, human coronavirus NL63 and 4 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| HCoV-229E Mpro | human coronavirus 229E | MCA-SLLQSEQQ-Lys(DNP) | 0.3378 | 0.1012 | 3.3 | pH 7.4, 25 °C | Open record: HCoV-229E Mpro, MCA-SLLQSEQQ-Lys(DNP) |
| HCoV-229E Mpro | human coronavirus 229E | MCA-TAB1_{441-448}-Lys (DNP) | 0.036 | 0.04474 | 0.83 | pH 7.4, 25 °C | Open record: HCoV-229E Mpro, MCA-TAB1_{441-448}-Lys (DNP) |
| HCoV-HKU1 Mpro | human coronavirus HKU1 | MCA-SLLQSEQQ-Lys(DNP) | 0.7942 | 0.1585 | 5 | pH 7.4, 25 °C | Open record: HCoV-HKU1 Mpro, MCA-SLLQSEQQ-Lys(DNP) |
| HCoV-HKU1 Mpro | human coronavirus HKU1 | MCA-TAB1_{441-448}-Lys (DNP) | 0.0277 | 0.02164 | 1.3 | pH 7.4, 25 °C | Open record: HCoV-HKU1 Mpro, MCA-TAB1_{441-448}-Lys (DNP) |
| HCoV-NL63 Mpro | human coronavirus NL63 | MCA-SLLQSEQQ-Lys(DNP) | 0.804 | 0.1659 | 4.8 | pH 7.4, 25 °C | Open record: HCoV-NL63 Mpro, MCA-SLLQSEQQ-Lys(DNP) |
| HCoV-NL63 Mpro | human coronavirus NL63 | MCA-TAB1_{441-448}-Lys (DNP) | 0.027 | 0.02129 | 1.3 | pH 7.4, 25 °C | Open record: HCoV-NL63 Mpro, MCA-TAB1_{441-448}-Lys (DNP) |
| HCoV-OC43 Mpro | human coronavirus OC43 | MCA-SLLQSEQQ-Lys(DNP) | 0.8425 | 0.1655 | 5 | pH 7.4, 25 °C | Open record: HCoV-OC43 Mpro, MCA-SLLQSEQQ-Lys(DNP) |
| HCoV-OC43 Mpro | human coronavirus OC43 | MCA-TAB1_{441-448}-Lys (DNP) | 0.0453 | 0.02518 | 1.8 | pH 7.4, 25 °C | Open record: HCoV-OC43 Mpro, MCA-TAB1_{441-448}-Lys (DNP) |
| MERS-CoV Mpro | Middle East respiratory syndrome coronavirus | MCA-SLLQSEQQ-Lys(DNP) | 0.3645 | 0.08846 | 4.2 | pH 7.4, 25 °C | Open record: MERS-CoV Mpro, MCA-SLLQSEQQ-Lys(DNP) |
| MERS-CoV Mpro | Middle East respiratory syndrome coronavirus | MCA-TAB1_{441-448}-Lys (DNP) | 0.2118 | 0.01381 | 15.3 | pH 7.4, 25 °C | Open record: MERS-CoV Mpro, MCA-TAB1_{441-448}-Lys (DNP) |
| SARS-CoV Mpro | severe acute respiratory syndrome coronavirus | MCA-SLLQSEQQ-Lys(DNP) | 0.8392 | 0.1698 | 5 | pH 7.4, 25 °C | Open record: SARS-CoV Mpro, MCA-SLLQSEQQ-Lys(DNP) |
| SARS-CoV Mpro | severe acute respiratory syndrome coronavirus | MCA-TAB1_{441-448}-Lys (DNP) | 0.252 | 0.01261 | 20.3 | pH 7.4, 25 °C | Open record: SARS-CoV Mpro, MCA-TAB1_{441-448}-Lys (DNP) |
| SARS-CoV-2 Mpro | severe acute respiratory syndrome coronavirus 2 | MCA-SLLQSEQQ-Lys(DNP) | 0.719 | 0.1471 | 4.8 | pH 7.4, 25 °C | Open record: SARS-CoV-2 Mpro, MCA-SLLQSEQQ-Lys(DNP) |
| SARS-CoV-2 Mpro | severe acute respiratory syndrome coronavirus 2 | MCA-TAB1_{441-448}-Lys (DNP) | 0.1543 | 0.00703 | 22 | pH 7.4, 25 °C | Open record: SARS-CoV-2 Mpro, MCA-TAB1_{441-448}-Lys (DNP) |