Values CatLog read from this paper

Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H…

PMID 8117659doi:10.1021/bi00174a007Open in Browse

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CatLog read 19 records (55 values) from this paper: aldose reductase from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.1.1.21

Records read from this paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Open record
aldose reductase	Homo sapiens	D-lyxose	0.16	2.63 × 10³	6 × 10⁻⁵	pH 7, 25 °C	Open record: aldose reductase, D-lyxose
aldose reductase	Homo sapiens	D-xylose	0.4	7.4	0.054	pH 7, 25 °C	Open record: aldose reductase, D-xylose
aldose reductase	Homo sapiens	DL-glyceraldehyde	0.24	—	4.3	25 °C	Open record: aldose reductase, DL-glyceraldehyde
aldose reductase	Homo sapiens	L-xylose	0.23	111	0.0021	pH 7, 25 °C	Open record: aldose reductase, L-xylose
aldose reductasevariant H110A	Homo sapiens	4-nitrobenzaldehyde	0.03	0.19	0.146	pH 7, 25 °C	Open record: aldose reductase variant H110A, 4-nitrobenzaldehyde
aldose reductasevariant H110A	Homo sapiens	D-lyxose	0.005	2.74 × 10³	2 × 10⁻⁶	pH 7, 25 °C	Open record: aldose reductase variant H110A, D-lyxose
aldose reductasevariant H110A	Homo sapiens	D-xylose	0.017	1.34 × 10³	1.3 × 10⁻⁵	pH 7, 25 °C	Open record: aldose reductase variant H110A, D-xylose
aldose reductasevariant H110A	Homo sapiens	DL-glyceraldehyde	0.07	84	9 × 10⁻⁴	pH 7, 25 °C	Open record: aldose reductase variant H110A, DL-glyceraldehyde
aldose reductasevariant H110A	Homo sapiens	L-xylose	0.0012	360	3 × 10⁻⁶	pH 7, 25 °C	Open record: aldose reductase variant H110A, L-xylose
aldose reductasevariant H110Q	Homo sapiens	4-nitrobenzaldehyde	0.02	0.86	0.023	pH 7, 25 °C	Open record: aldose reductase variant H110Q, 4-nitrobenzaldehyde
aldose reductasevariant H110Q	Homo sapiens	D-lyxose	0.0075	506	1.4 × 10⁻⁵	pH 7, 25 °C	Open record: aldose reductase variant H110Q, D-lyxose
aldose reductasevariant H110Q	Homo sapiens	D-xylose	0.054	861	6.3 × 10⁻⁵	pH 7, 25 °C	Open record: aldose reductase variant H110Q, D-xylose
aldose reductasevariant H110Q	Homo sapiens	DL-glyceraldehyde	0.25	12	0.021	pH 7, 25 °C	Open record: aldose reductase variant H110Q, DL-glyceraldehyde
aldose reductasevariant H110Q	Homo sapiens	L-xylose	0.0065	1.19 × 10³	5.9 × 10⁻⁶	pH 7, 25 °C	Open record: aldose reductase variant H110Q, L-xylose
aldose reductasevariant Y48H	Homo sapiens	4-nitrobenzaldehyde	0.01	0.1	0.074	pH 7, 25 °C	Open record: aldose reductase variant Y48H, 4-nitrobenzaldehyde
aldose reductasevariant Y48H	Homo sapiens	DL-glyceraldehyde	0.01	71	2 × 10⁻⁴	pH 7, 25 °C	Open record: aldose reductase variant Y48H, DL-glyceraldehyde
aldose reductasevariant Y48H	Homo sapiens	DL-glyceraldehyde	0.013	—	9 × 10⁻⁵	25 °C	Open record: aldose reductase variant Y48H, DL-glyceraldehyde
aldose reductasevariant Y48S	Homo sapiens	4-nitrobenzaldehyde	0.002	0.88	0.0025	pH 7, 25 °C	Open record: aldose reductase variant Y48S, 4-nitrobenzaldehyde
aldose reductasevariant Y48S	Homo sapiens	DL-glyceraldehyde	0.01	64	7 × 10⁻⁵	pH 7, 25 °C	Open record: aldose reductase variant Y48S, DL-glyceraldehyde