CatLogenzyme kinetics catalog

Values CatLog read from this paper

Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core

PMID 8119978doi:10.1016/s0021-9258(17)37371-4Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 19 records (56 values) from this paper: acetylcholinesterase (HuAChE) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 1 kcat/Km value marked “calc.” from kcat and Km; no printed kcat/Km was read for that record.

EC 3.1.1.7

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
acetylcholinesterase (HuAChE)Homo sapiensacetylthiocholine iodide7 × 10³0.125.8 × 10⁴ calc.pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant D74NHomo sapiensacetylthiocholine iodide4.2 × 10³0.67 × 10³pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant E285AHomo sapiensacetylthiocholine iodide6.3 × 10³0.282.27 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant E285A/W286AHomo sapiensacetylthiocholine iodide7.3 × 10³0.352.1 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant F295AHomo sapiensacetylthiocholine iodide5 × 10³0.133.83 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant F297AHomo sapiensacetylthiocholine iodide2 × 10³0.316.5 × 10³pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant F338AHomo sapiensacetylthiocholine iodide2.8 × 10³0.142.02 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant W286AHomo sapiensacetylthiocholine iodide5.3 × 10³0.22.67 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant W86AHomo sapiensacetylthiocholine iodide1.3 × 10³9315pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y124AHomo sapiensacetylthiocholine iodide4.2 × 10³0.251.67 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y124A/E285A/W286AHomo sapiensacetylthiocholine iodide2.3 × 10³0.288.3 × 10³pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y337AHomo sapiensacetylthiocholine iodide1.7 × 10³0.11.67 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y337FHomo sapiensacetylthiocholine iodide6.7 × 10³0.164.17 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y341AHomo sapiensacetylthiocholine iodide4.2 × 10³0.31.38 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y72AHomo sapiensacetylthiocholine iodide6.3 × 10³0.134.87 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y72A/E285AHomo sapiensacetylthiocholine iodide6.7 × 10³0.242.78 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y72A/E285A/W286AHomo sapiensacetylthiocholine iodide3.3 × 10³0.31.12 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y72A/W286AHomo sapiensacetylthiocholine iodide7 × 10³0.32.33 × 10⁴pH 8, 27 °COpen
acetylcholinesterase (HuAChE)variant Y72A/Y124AHomo sapiensacetylthiocholine iodide4.2 × 10³0.075.95 × 10⁴pH 8, 27 °COpen