EC 3.1.1.7: acetylcholinesterase

HydrolasesOpen in Browse

CatLog read 134 records for EC 3.1.1.7 from 12 papers, for 5 organisms. Names in these papers: human acetylcholinesterase (HuAChE), acetylcholinesterase (HuAChE), acetylcholinesterase, acetylcholinesterase (AChE) and 5 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 158 records for EC 3.1.1.7 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.1.7 in Browse.

Papers

Papers with records for EC 3.1.1.7
Paper	Organisms	Records
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket	Homo sapiens	45
Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core	Homo sapiens	19
Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors	Mus musculus	16
Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center	Homo sapiens	13
Solubilization, molecular forms, purification and substrate specificity of two acetylcholinesterases in the medicinal leech (Hirudo medicinalis)	Hirudo medicinalis	12
Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates	Mus musculus	9
Probing the active center gorge of acetylcholinesterase by fluorophores linked to substituted cysteines	Mus musculus	8
Expression, Characterization and Selective Chemical Inhibition of Essential Schistosoma mansoni Tegumental Acetylcholinesterase (SmTAChE)	Schistosoma mansoni	4
Lipoamidase is a multiple hydrolase	electric eel	3
Characterization of butyrylcholinesterase from porcine milk	Homo sapiens	2
Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphine	Homo sapiens	2
Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases	Homo sapiens	1

Records

Records for EC 3.1.1.7 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
acetylcholinesterase	electric eel	acetylcholine	—	0.368	—	pH 7, 37 °C	PMID 2222421	Open record: acetylcholinesterase, acetylcholine
acetylcholinesterase	electric eel	Arg-Phe	—	2.867	—	pH 7, 37 °C	PMID 2222421	Open record: acetylcholinesterase, Arg-Phe
acetylcholinesterase	electric eel	aspartame	—	1.264	—	pH 7, 37 °C	PMID 2222421	Open record: acetylcholinesterase, aspartame
acetylcholinesterase	Homo sapiens	acetylthiocholine iodide	7.18 × 10³	0.11	6.48 × 10⁴	pH 8, 22 °C	PMID 29908755	Open record: acetylcholinesterase, acetylthiocholine iodide
acetylcholinesterase	Homo sapiens	propionylthiocholine iodide	3.72 × 10³	0.15	2.52 × 10⁴	pH 8, 22 °C	PMID 29908755	Open record: acetylcholinesterase, propionylthiocholine iodide
acetylcholinesterase	Mus musculus	acetylthiocholine iodide	2.5 × 10³	0.047	5.3 × 10⁴	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase, acetylthiocholine iodide
acetylcholinesterasevariant D74N	Mus musculus	acetylthiocholine	1.4 × 10³	1.3	1.05 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant D74N, acetylthiocholine
acetylcholinesterasevariant E202Q/F295L/Y337A	Mus musculus	acetylthiocholine iodide	170	0.1	1.7 × 10³	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant E202Q/F295L/Y337A, acetylthiocholine iodide
acetylcholinesterasevariant F295A/F297A/Y337A	Mus musculus	acetylthiocholine iodide	180	0.19	970	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant F295A/F297A/Y337A, acetylthiocholine iodide
acetylcholinesterasevariant F295A/Y337A	Mus musculus	acetylthiocholine iodide	330	0.076	4.3 × 10³	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant F295A/Y337A, acetylthiocholine iodide
acetylcholinesterasevariant F295L/F297I/Y337A	Mus musculus	acetylthiocholine iodide	250	0.069	3.7 × 10³	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant F295L/F297I/Y337A, acetylthiocholine iodide
acetylcholinesterasevariant F295L/Y337A	Mus musculus	acetylthiocholine iodide	670	0.1	6.7 × 10³	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant F295L/Y337A, acetylthiocholine iodide
acetylcholinesterasevariant F295L/Y337A/F338A	Mus musculus	acetylthiocholine iodide	280	0.15	1.8 × 10³	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant F295L/Y337A/F338A, acetylthiocholine iodide
acetylcholinesterasevariant F295Y	Mus musculus	acetylthiocholine	102	0.017	6 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant F295Y, acetylthiocholine
acetylcholinesterasevariant F297I/Y337A	Mus musculus	acetylthiocholine iodide	230	0.34	680	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant F297I/Y337A, acetylthiocholine iodide
acetylcholinesterasevariant F297Y	Mus musculus	acetylthiocholine	650	0.058	1.12 × 10⁴	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant F297Y, acetylthiocholine
acetylcholinesterasevariant F338G	Mus musculus	acetylthiocholine	380	0.075	5.2 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant F338G, acetylthiocholine
acetylcholinesterasevariant W286R	Mus musculus	acetylthiocholine	2.7 × 10³	0.42	6.3 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant W286R, acetylthiocholine
acetylcholinesterasevariant Y124Q	Mus musculus	acetylthiocholine	1.8 × 10³	0.12	1.57 × 10⁴	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y124Q, acetylthiocholine
acetylcholinesterasevariant Y124Q/W286R	Mus musculus	acetylthiocholine	2.7 × 10³	0.7	3.8 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y124Q/W286R, acetylthiocholine
acetylcholinesterasevariant Y337A	Mus musculus	acetylthiocholine	870	0.11	7.7 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y337A, acetylthiocholine
acetylcholinesterasevariant Y337A/F338A	Mus musculus	acetylthiocholine iodide	650	0.15	4.3 × 10³	pH 7, 22 °C	PMID 12665427	Open record: acetylcholinesterase variant Y337A/F338A, acetylthiocholine iodide
acetylcholinesterasevariant Y337F	Mus musculus	acetylthiocholine	1.13 × 10³	0.053	2.2 × 10⁴	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y337F, acetylthiocholine
acetylcholinesterasevariant Y72N	Mus musculus	acetylthiocholine	2.2 × 10³	0.11	2 × 10⁴	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y72N, acetylthiocholine
acetylcholinesterasevariant Y72N/D74N/Y124Q/W286A	Mus musculus	acetylthiocholine	2.5 × 10³	2.1	1.18 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y72N/D74N/Y124Q/W286A, acetylthiocholine
acetylcholinesterasevariant Y72N/D74N/Y124Q/W286R	Mus musculus	acetylthiocholine	2.3 × 10³	6.1	380	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y72N/D74N/Y124Q/W286R, acetylthiocholine
acetylcholinesterasevariant Y72N/W286R	Mus musculus	acetylthiocholine	3.2 × 10³	0.67	4.7 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y72N/W286R, acetylthiocholine
acetylcholinesterasevariant Y72N/Y124Q	Mus musculus	acetylthiocholine	1.57 × 10³	0.095	1.65 × 10⁴	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y72N/Y124Q, acetylthiocholine
acetylcholinesterasevariant Y72N/Y124Q/W286A	Mus musculus	acetylthiocholine	2.5 × 10³	0.23	1.12 × 10⁴	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y72N/Y124Q/W286A, acetylthiocholine
acetylcholinesterasevariant Y72N/Y124Q/W286R	Mus musculus	acetylthiocholine	3.5 × 10³	0.85	4.2 × 10³	pH 7, 22 °C	PMID 8218285	Open record: acetylcholinesterase variant Y72N/Y124Q/W286R, acetylthiocholine
acetylcholinesterase (AChE)variant A262C	Mus musculus	acetylthiocholine	2.73 × 10³	0.059	4.7 × 10⁴		PMID 10779503	Open record: acetylcholinesterase (AChE) variant A262C, acetylthiocholine
acetylcholinesterase (AChE)variant H287C	Mus musculus	acetylthiocholine	3 × 10³	0.058	5.2 × 10⁴		PMID 10779503	Open record: acetylcholinesterase (AChE) variant H287C, acetylthiocholine
acetylcholinesterase (AChE)variant Y124C	Mus musculus	acetylthiocholine	2.37 × 10³	0.065	3.7 × 10⁴		PMID 10779503	Open record: acetylcholinesterase (AChE) variant Y124C, acetylthiocholine
acetylcholinesterase (AChE)variant Y124C-N(CH3)3+ (Cys124 modified with MTSET, 2-(trimethylammonium)ethyl methanethiosulfonate)	Mus musculus	acetylthiocholine	1.85 × 10³	1.13	1.63 × 10³		PMID 10779503	Open record: acetylcholinesterase (AChE) variant Y124C-N(CH3)3+ (Cys124 modified with MTSET, 2-(trimethylammonium)ethyl methanethiosulfonate), acetylthiocholine
acetylcholinesterase (AChE)variant Y124C-NH3+ (Cys124 modified with MTSEA, 2-aminoethyl methanethiosulfonate)	Mus musculus	acetylthiocholine	4.35 × 10³	2.36	1.8 × 10³		PMID 10779503	Open record: acetylcholinesterase (AChE) variant Y124C-NH3+ (Cys124 modified with MTSEA, 2-aminoethyl methanethiosulfonate), acetylthiocholine
acetylcholinesterase (AChE)variant Y124C-SO3− (Cys124 modified with MTSES, sodium (2-sulfonatoethyl)methanethiosulfonate)	Mus musculus	acetylthiocholine	2.13 × 10³	0.058	3.7 × 10⁴		PMID 10779503	Open record: acetylcholinesterase (AChE) variant Y124C-SO3− (Cys124 modified with MTSES, sodium (2-sulfonatoethyl)methanethiosulfonate), acetylthiocholine
acetylcholinesterase (AChE)variant Y124C-acrylodan (Cys124 conjugated with acrylodan)	Mus musculus	acetylthiocholine	95	0.28	330		PMID 10779503	Open record: acetylcholinesterase (AChE) variant Y124C-acrylodan (Cys124 conjugated with acrylodan), acetylthiocholine
acetylcholinesterase (AChE)variant Y124C-benzyl (Cys124 modified with benzyl methanethiosulfonate, MTSBn)	Mus musculus	acetylthiocholine	1.33 × 10³	0.059	2.3 × 10⁴		PMID 10779503	Open record: acetylcholinesterase (AChE) variant Y124C-benzyl (Cys124 modified with benzyl methanethiosulfonate, MTSBn), acetylthiocholine
acetylcholinesterase (HuAChE)	Homo sapiens	acetylthiocholine	6.2 × 10³	0.14	4.67 × 10⁴	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE), acetylthiocholine
acetylcholinesterase (HuAChE)	Homo sapiens	acetylthiocholine iodide	7 × 10³	0.12	5.8 × 10⁴ calc.	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE), acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant D74E	Homo sapiens	acetylthiocholine	7.3 × 10³	0.5	1.47 × 10⁴	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant D74E, acetylthiocholine
acetylcholinesterase (HuAChE)variant D74G	Homo sapiens	acetylthiocholine	6 × 10³	0.63	9.5 × 10³	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant D74G, acetylthiocholine
acetylcholinesterase (HuAChE)variant D74K	Homo sapiens	acetylthiocholine	5.8 × 10³	4.5	1.3 × 10³	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant D74K, acetylthiocholine
acetylcholinesterase (HuAChE)variant D74N	Homo sapiens	acetylthiocholine	4.5 × 10³	0.58	7.7 × 10³	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant D74N, acetylthiocholine
acetylcholinesterase (HuAChE)variant D74N	Homo sapiens	acetylthiocholine iodide	4.2 × 10³	0.6	7 × 10³	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant D74N, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant E202A	Homo sapiens	acetylthiocholine	170	0.66	330	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant E202A, acetylthiocholine
acetylcholinesterase (HuAChE)variant E202D	Homo sapiens	acetylthiocholine	250	0.25	1 × 10³	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant E202D, acetylthiocholine
acetylcholinesterase (HuAChE)variant E202Q	Homo sapiens	acetylthiocholine	930	0.35	2.7 × 10³	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant E202Q, acetylthiocholine
acetylcholinesterase (HuAChE)variant E285A	Homo sapiens	acetylthiocholine iodide	6.3 × 10³	0.28	2.27 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant E285A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant E285A/W286A	Homo sapiens	acetylthiocholine iodide	7.3 × 10³	0.35	2.1 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant E285A/W286A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant F295A	Homo sapiens	acetylthiocholine iodide	5 × 10³	0.13	3.83 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant F295A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant F297A	Homo sapiens	acetylthiocholine iodide	2 × 10³	0.31	6.5 × 10³	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant F297A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	acetylthiocholine	2.8 × 10³	0.27	1.05 × 10⁴	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant F338A, acetylthiocholine
acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	acetylthiocholine iodide	2.8 × 10³	0.14	2.02 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant F338A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant W286A	Homo sapiens	acetylthiocholine	6.7 × 10³	0.28	2.38 × 10⁴	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant W286A, acetylthiocholine
acetylcholinesterase (HuAChE)variant W286A	Homo sapiens	acetylthiocholine iodide	5.3 × 10³	0.2	2.67 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant W286A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant W86A	Homo sapiens	acetylthiocholine iodide	1.3 × 10³	93	15	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant W86A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y124A	Homo sapiens	acetylthiocholine iodide	4.2 × 10³	0.25	1.67 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y124A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y124A/E285A/W286A	Homo sapiens	acetylthiocholine iodide	2.3 × 10³	0.28	8.3 × 10³	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y124A/E285A/W286A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	acetylthiocholine	1.7 × 10³	0.14	1.18 × 10⁴	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant Y337A, acetylthiocholine
acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	acetylthiocholine iodide	1.7 × 10³	0.1	1.67 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y337A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y337F	Homo sapiens	acetylthiocholine	6.2 × 10³	0.19	3.25 × 10⁴	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant Y337F, acetylthiocholine
acetylcholinesterase (HuAChE)variant Y337F	Homo sapiens	acetylthiocholine iodide	6.7 × 10³	0.16	4.17 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y337F, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y341A	Homo sapiens	acetylthiocholine	5.3 × 10³	0.4	1.33 × 10⁴	pH 8, 27 °C	PMID 1396557	Open record: acetylcholinesterase (HuAChE) variant Y341A, acetylthiocholine
acetylcholinesterase (HuAChE)variant Y341A	Homo sapiens	acetylthiocholine iodide	4.2 × 10³	0.3	1.38 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y341A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y72A	Homo sapiens	acetylthiocholine iodide	6.3 × 10³	0.13	4.87 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y72A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y72A/E285A	Homo sapiens	acetylthiocholine iodide	6.7 × 10³	0.24	2.78 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y72A/E285A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y72A/E285A/W286A	Homo sapiens	acetylthiocholine iodide	3.3 × 10³	0.3	1.12 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y72A/E285A/W286A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y72A/W286A	Homo sapiens	acetylthiocholine iodide	7 × 10³	0.3	2.33 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y72A/W286A, acetylthiocholine iodide
acetylcholinesterase (HuAChE)variant Y72A/Y124A	Homo sapiens	acetylthiocholine iodide	4.2 × 10³	0.07	5.95 × 10⁴	pH 8, 27 °C	PMID 8119978	Open record: acetylcholinesterase (HuAChE) variant Y72A/Y124A, acetylthiocholine iodide
AChE (acetylcholinesterase)	Homo sapiens	3,6-diacetylmorphine	35	2.17	16.13	pH 7.4, 37 °C	PMID 30080993	Open record: AChE (acetylcholinesterase), 3,6-diacetylmorphine
AChE (acetylcholinesterase)	Homo sapiens	6-monoacetylmorphine	0.118	0.259	0.455	pH 7.4, 37 °C	PMID 30080993	Open record: AChE (acetylcholinesterase), 6-monoacetylmorphine
DS-AChE (detergent-soluble acetylcholinesterase)	Hirudo medicinalis	4-nitrophenyl acetate	0.23	2	0.11		PMID 7702560	Open record: DS-AChE (detergent-soluble acetylcholinesterase), 4-nitrophenyl acetate
DS-AChE (detergent-soluble acetylcholinesterase)	Hirudo medicinalis	4-nitrophenyl butyrate	0.03	0.4	0.07		PMID 7702560	Open record: DS-AChE (detergent-soluble acetylcholinesterase), 4-nitrophenyl butyrate
DS-AChE (detergent-soluble acetylcholinesterase)	Hirudo medicinalis	4-nitrophenyl propionate	1.59	2.5	0.64		PMID 7702560	Open record: DS-AChE (detergent-soluble acetylcholinesterase), 4-nitrophenyl propionate
DS-AChE (detergent-soluble acetylcholinesterase)	Hirudo medicinalis	acetylthiocholine	29.73	0.025	1.19 × 10³	pH 7.2, 25 °C	PMID 7702560	Open record: DS-AChE (detergent-soluble acetylcholinesterase), acetylthiocholine
DS-AChE (detergent-soluble acetylcholinesterase)	Hirudo medicinalis	butyrylthiocholine	3.95	0.035	113	pH 7.2, 25 °C	PMID 7702560	Open record: DS-AChE (detergent-soluble acetylcholinesterase), butyrylthiocholine
DS-AChE (detergent-soluble acetylcholinesterase)	Hirudo medicinalis	propionylthiocholine	44.52	0.032	1.39 × 10³	pH 7.2, 25 °C	PMID 7702560	Open record: DS-AChE (detergent-soluble acetylcholinesterase), propionylthiocholine
hAChE (human acetylcholinesterase)	Homo sapiens	1RS trans-permethrin	1.3 × 10⁻⁴	—	—		PMID 16387282	Open record: hAChE (human acetylcholinesterase), 1RS trans-permethrin
human acetylcholinesterase (HuAChE)	Homo sapiens	acetylthiocholine	6.2 × 10³	0.14	4.4 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE), acetylthiocholine
human acetylcholinesterase (HuAChE)	Homo sapiens	butyrylthiocholine	125	0.3	420	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE), butyrylthiocholine
human acetylcholinesterase (HuAChE)	Homo sapiens	p-nitrophenyl acetate	1.8 × 10³	5.6	333	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE), p-nitrophenyl acetate
human acetylcholinesterase (HuAChE)	Homo sapiens	propionylthiocholine	2.7 × 10³	0.25	1.07 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE), propionylthiocholine
human acetylcholinesterase (HuAChE)	Homo sapiens	S-3,3-dimethylbutyl thioacetate	870	0.45	1.93 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE), S-3,3-dimethylbutyl thioacetate
human acetylcholinesterase (HuAChE)	Homo sapiens	S-n-propyl thioacetate	183	11	16.7	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE), S-n-propyl thioacetate
human acetylcholinesterase (HuAChE)variant F295A	Homo sapiens	acetylthiocholine	6.3 × 10³	0.13	4.87 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295A, acetylthiocholine
human acetylcholinesterase (HuAChE)variant F295A	Homo sapiens	butyrylthiocholine	500	0.009	5.55 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295A, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant F295A	Homo sapiens	propionylthiocholine	1.7 × 10³	0.06	2.78 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295A, propionylthiocholine
human acetylcholinesterase (HuAChE)variant F295L	Homo sapiens	acetylthiocholine	2 × 10³	0.2	1 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295L, acetylthiocholine
human acetylcholinesterase (HuAChE)variant F295L	Homo sapiens	butyrylthiocholine	500	0.03	1.67 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295L, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant F295L	Homo sapiens	propionylthiocholine	1.5 × 10³	0.25	6 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295L, propionylthiocholine
human acetylcholinesterase (HuAChE)variant F295L/F297V	Homo sapiens	acetylthiocholine	1.5 × 10³	0.4	3.7 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295L/F297V, acetylthiocholine
human acetylcholinesterase (HuAChE)variant F295L/F297V	Homo sapiens	butyrylthiocholine	700	0.03	2.33 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295L/F297V, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant F295L/F297V	Homo sapiens	propionylthiocholine	1.5 × 10³	0.43	3.5 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F295L/F297V, propionylthiocholine
human acetylcholinesterase (HuAChE)variant F297A	Homo sapiens	acetylthiocholine	2 × 10³	0.55	3.7 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F297A, acetylthiocholine
human acetylcholinesterase (HuAChE)variant F297A	Homo sapiens	butyrylthiocholine	830	0.36	2.3 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F297A, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant F297A	Homo sapiens	propionylthiocholine	1.7 × 10³	0.78	2.2 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F297A, propionylthiocholine
human acetylcholinesterase (HuAChE)variant F297V	Homo sapiens	acetylthiocholine	3.7 × 10³	1.2	3 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F297V, acetylthiocholine
human acetylcholinesterase (HuAChE)variant F297V	Homo sapiens	butyrylthiocholine	1 × 10³	0.38	2.7 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F297V, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant F297V	Homo sapiens	propionylthiocholine	1.7 × 10³	0.7	2.3 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F297V, propionylthiocholine
human acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	acetylthiocholine	2.8 × 10³	0.3	9.5 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F338A, acetylthiocholine
human acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	butyrylthiocholine	58	0.8	67	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F338A, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	p-nitrophenyl acetate	330	8.6	38	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F338A, p-nitrophenyl acetate
human acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	propionylthiocholine	830	0.34	2.5 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F338A, propionylthiocholine
human acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	S-3,3-dimethylbutyl thioacetate	220	0.3	720	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F338A, S-3,3-dimethylbutyl thioacetate
human acetylcholinesterase (HuAChE)variant F338A	Homo sapiens	S-n-propyl thioacetate	80	11.7	6.7	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant F338A, S-n-propyl thioacetate
human acetylcholinesterase (HuAChE)variant W286A	Homo sapiens	acetylthiocholine	6.7 × 10³	0.4	1.7 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W286A, acetylthiocholine
human acetylcholinesterase (HuAChE)variant W286A	Homo sapiens	p-nitrophenyl acetate	2.2 × 10³	4.6	467	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W286A, p-nitrophenyl acetate
human acetylcholinesterase (HuAChE)variant W286A	Homo sapiens	S-3,3-dimethylbutyl thioacetate	770	0.4	1.9 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W286A, S-3,3-dimethylbutyl thioacetate
human acetylcholinesterase (HuAChE)variant W286A	Homo sapiens	S-n-propyl thioacetate	160	8.2	20	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W286A, S-n-propyl thioacetate
human acetylcholinesterase (HuAChE)variant W86A	Homo sapiens	acetylthiocholine	1.3 × 10³	93.3	14.3	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W86A, acetylthiocholine
human acetylcholinesterase (HuAChE)variant W86A	Homo sapiens	p-nitrophenyl acetate	3.2 × 10³	3	1.05 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W86A, p-nitrophenyl acetate
human acetylcholinesterase (HuAChE)variant W86A	Homo sapiens	S-3,3-dimethylbutyl thioacetate	470	0.55	850	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W86A, S-3,3-dimethylbutyl thioacetate
human acetylcholinesterase (HuAChE)variant W86A	Homo sapiens	S-n-propyl thioacetate	23	11.5	2	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant W86A, S-n-propyl thioacetate
human acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	acetylthiocholineTable I	1.7 × 10³	0.14	1.18 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337A, acetylthiocholine
human acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	acetylthiocholineTable IV	1.7 × 10³	0.13	1.28 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337A, acetylthiocholine
human acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	butyrylthiocholine	50	0.27	170	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337A, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	p-nitrophenyl acetate	1.6 × 10³	5.4	300	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337A, p-nitrophenyl acetate
human acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	propionylthiocholine	170	0.17	1 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337A, propionylthiocholine
human acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	S-3,3-dimethylbutyl thioacetate	1.38 × 10³	0.5	2.77 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337A, S-3,3-dimethylbutyl thioacetate
human acetylcholinesterase (HuAChE)variant Y337A	Homo sapiens	S-n-propyl thioacetate	250	10	25	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337A, S-n-propyl thioacetate
human acetylcholinesterase (HuAChE)variant Y337F	Homo sapiens	acetylthiocholine	6.2 × 10³	0.2	3.08 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337F, acetylthiocholine
human acetylcholinesterase (HuAChE)variant Y337F	Homo sapiens	butyrylthiocholine	170	0.11	1.5 × 10³	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337F, butyrylthiocholine
human acetylcholinesterase (HuAChE)variant Y337F	Homo sapiens	propionylthiocholine	2.3 × 10³	0.15	1.55 × 10⁴	pH 8, 27 °C	PMID 8349597	Open record: human acetylcholinesterase (HuAChE) variant Y337F, propionylthiocholine
SS-AChE (spontaneously soluble acetylcholinesterase)	Hirudo medicinalis	4-nitrophenyl acetate	0.93	0.56	1.66		PMID 7702560	Open record: SS-AChE (spontaneously soluble acetylcholinesterase), 4-nitrophenyl acetate
SS-AChE (spontaneously soluble acetylcholinesterase)	Hirudo medicinalis	4-nitrophenyl butyrate	2.09	0.16	13.1		PMID 7702560	Open record: SS-AChE (spontaneously soluble acetylcholinesterase), 4-nitrophenyl butyrate
SS-AChE (spontaneously soluble acetylcholinesterase)	Hirudo medicinalis	4-nitrophenyl propionate	4.06	0.38	10.5		PMID 7702560	Open record: SS-AChE (spontaneously soluble acetylcholinesterase), 4-nitrophenyl propionate
SS-AChE (spontaneously soluble acetylcholinesterase)	Hirudo medicinalis	acetylthiocholine	11.7	0.07	167	pH 7.2, 25 °C	PMID 7702560	Open record: SS-AChE (spontaneously soluble acetylcholinesterase), acetylthiocholine
SS-AChE (spontaneously soluble acetylcholinesterase)	Hirudo medicinalis	butyrylthiocholine	29.1	0.078	337	pH 7.2, 25 °C	PMID 7702560	Open record: SS-AChE (spontaneously soluble acetylcholinesterase), butyrylthiocholine
SS-AChE (spontaneously soluble acetylcholinesterase)	Hirudo medicinalis	propionylthiocholine	41.6	0.123	338	pH 7.2, 25 °C	PMID 7702560	Open record: SS-AChE (spontaneously soluble acetylcholinesterase), propionylthiocholine
tegumental acetylcholinesterase (SmTAChE)	Schistosoma mansoni	acetylthiocholine	372.8	0.32	1.17 × 10³	pH 7.2, 25 °C	PMID 40076600	Open record: tegumental acetylcholinesterase (SmTAChE), acetylthiocholine
tegumental acetylcholinesterase (SmTAChE)	Schistosoma mansoni	acetylthiocholine	—	0.39	—		PMID 40076600	Open record: tegumental acetylcholinesterase (SmTAChE), acetylthiocholine
tegumental acetylcholinesterase (SmTAChE)	Schistosoma mansoni	butyrylthiocholine	10.67	0.33	30	pH 7.2, 25 °C	PMID 40076600	Open record: tegumental acetylcholinesterase (SmTAChE), butyrylthiocholine
tegumental acetylcholinesterase (SmTAChE)	Schistosoma mansoni	propionylthiocholine	74.16	0.14	530	pH 7.2, 25 °C	PMID 40076600	Open record: tegumental acetylcholinesterase (SmTAChE), propionylthiocholine