Values CatLog read from this paper
Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors
PMID 9268299doi:10.1074/jbc.272.35.21713Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 29 records (87 values) from this paper: tissue-type plasminogen activator (single-chain tPA) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | D-alpha-aspartyl-glycyl-L-arginine 4-nitroanilide | 0.43 | 1.7 | 0.25 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), D-alpha-aspartyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | D-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide | 3.98 | 2.9 | 1.37 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), D-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | D-cyclohexylglycyl-glycyl-L-arginine 4-nitroanilide | 6.74 | 1.53 | 4.4 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), D-cyclohexylglycyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | D-hexahydrotyrosyl-glycyl-L-arginine 4-nitroanilide | 10.6 | 0.83 | 12.8 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), D-hexahydrotyrosyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | D-lysyl-glycyl-L-arginine 4-nitroanilide | 6.32 | 2.1 | 3.01 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), D-lysyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | D-phenylalanyl-glycyl-L-arginine 4-nitroanilide | 7.46 | 0.7 | 10.7 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), D-phenylalanyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | L-alpha-aspartyl-glycyl-L-arginine 4-nitroanilide | 0.28 | 0.86 | 0.32 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), L-alpha-aspartyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | L-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide | 0.13 | 3.2 | 0.041 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), L-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | L-cyclohexylglycyl-glycyl-L-arginine 4-nitroanilide | 1.36 | 5.32 | 0.26 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), L-cyclohexylglycyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | L-phenylalanyl-glycyl-L-arginine 4-nitroanilide | 2.79 | 2 | 1.4 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), L-phenylalanyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-D-alpha-aspartyl(beta-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide | 4.98 | 1.8 | 2.77 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-D-alpha-aspartyl(beta-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-D-alpha-glutamyl(gamma-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide | 4.48 | 1.2 | 3.73 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-D-alpha-glutamyl(gamma-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-D-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide | 7.46 | 2.6 | 2.87 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-D-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-D-arginyl-glycyl-L-arginine 4-nitroanilide | 8.53 | 0.52 | 16.4 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-D-arginyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-D-phenylalanyl-glycyl-L-arginine 4-nitroanilide | 8.96 | 0.3 | 19.9 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-D-phenylalanyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-L-alpha-aspartyl(beta-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide | 1.84 | 2.3 | 0.8 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-L-alpha-aspartyl(beta-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-L-alpha-aspartyl-glycyl-L-arginine 4-nitroanilide | 0.35 | 0.72 | 0.49 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-L-alpha-aspartyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-L-alpha-glutamyl(gamma-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide | 1.29 | 0.9 | 1.43 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-L-alpha-glutamyl(gamma-tert-butyl ester)-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-L-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide | 0.75 | 2.2 | 0.34 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-L-alpha-glutamyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-benzyloxycarbonyl-L-valyl-glycyl-L-arginine 4-nitroanilide | 1.69 | 1.36 | 1.24 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-benzyloxycarbonyl-L-valyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-methoxycarbonyl-D-cyclohexylalanyl-glycyl-L-arginine 4-nitroanilide | 7.76 | 0.34 | 22.8 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-methoxycarbonyl-D-cyclohexylalanyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-methoxycarbonyl-D-cyclohexylglycyl-glycyl-L-arginine 4-nitroanilide | 5.02 | 0.42 | 11.9 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-methoxycarbonyl-D-cyclohexylglycyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-methoxycarbonyl-D-hexahydrotyrosyl-glycyl-L-arginine 4-nitroanilide | 8.31 | 0.39 | 21.3 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-methoxycarbonyl-D-hexahydrotyrosyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-methoxycarbonyl-D-leucyl-glycyl-L-arginine 4-nitroanilide | 6.92 | 0.62 | 11.2 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-methoxycarbonyl-D-leucyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-methoxycarbonyl-D-norleucyl-glycyl-L-arginine 4-nitroanilide | 6.82 | 0.99 | 6.89 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-methoxycarbonyl-D-norleucyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-methoxycarbonyl-D-valyl-glycyl-L-arginine 4-nitroanilide | 5.77 | 0.8 | 7.22 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-methoxycarbonyl-D-valyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-methylsulfonyl-D-phenylalanyl-glycyl-L-arginine 4-nitroanilide | 7.36 | 0.1 | 73.6 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-methylsulfonyl-D-phenylalanyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | N-tert-butoxycarbonyl-glycyl-glycyl-L-arginine 4-nitroanilide | 1.29 | 3.5 | 0.37 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), N-tert-butoxycarbonyl-glycyl-glycyl-L-arginine 4-nitroanilide |
| tissue-type plasminogen activator (single-chain tPA) | Homo sapiens | pyroglutamyl-glycyl-L-arginine 4-nitroanilide | 4.04 | 3.15 | 1.28 | pH 8, 25 °C | Open record: tissue-type plasminogen activator (single-chain tPA), pyroglutamyl-glycyl-L-arginine 4-nitroanilide |