CatLogenzyme kinetics catalog

EC 1.1.1.146: 11beta-hydroxysteroid dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 28 records for EC 1.1.1.146 from 3 papers, for 4 organisms. Names in these papers: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 39 records for EC 1.1.1.146 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.146 in Browse.

Papers

PaperOrganismsRecords
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzymeRattus norvegicus11
Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) speciesCavia porcellus, Homo sapiens10
11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivoMus musculus7

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Cavia porcelluscortisol0.0350.003110.5pH 9.2, 37 °CPMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Cavia porcelluscortisone—0.0022—pH 7.4, 37 °CPMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Cavia porcelluscortisone1-3 h incubation with cortisone plus 3H-labeled tracer—2.8 × 10⁻⁴—PMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Cavia porcelluscortisonehomogenates of transiently transfected COS7 cells—0.0082—PMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Cavia porcelluscortisone0.0096 × 10⁻⁴22pH 6, 37 °CPMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapienscortisol0.1850.002963pH 9.2, 37 °CPMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapienscortisone—0.0019—pH 7.4, 37 °CPMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapienscortisone1-3 h incubation with cortisone plus 3H-labeled tracer—3.3 × 10⁻⁴—PMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapienscortisonehomogenates of transiently transfected COS7 cells—0.0089—PMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapienscortisone0.0278 × 10⁻⁴25pH 6, 37 °CPMID 12397058Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone500 µM NADPH; recombinant; cell lysate—3.07 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone—6.81 × 10⁻⁴—37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone400 µM NADPH—3.63 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one500 µM NADPH; recombinant; cell lysate—4.2 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one—7.76 × 10⁻⁴—37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one400 µM NADPH—5.72 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus5-cholesten-3β,7β-diol500 µM NADP+; recombinant; cell lysate—7.51 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus5-cholesten-3β,7β-diol400 µM NADP+—7.67 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone500 µM NADP+; recombinant; cell lysate—0.00117—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone—3.67 × 10⁻⁴—37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone400 µM NADP+—0.001041—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)Mus musculus11-dehydrocorticosteronerecombinant protein 14–28 μg/mL—2 × 10⁻⁴—37 °CPMID 23415904Open
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)Mus musculus11-dehydrocorticosteronehepatic microsomal protein 240–260 μg/mL—0.0013—37 °CPMID 23415904Open
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)Mus musculus7-ketocholesterol—1.269—pH 7.4, 37 °CPMID 23415904Open
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)Mus musculus7β-hydroxycholesterolrecombinant protein 14–28 μg/mL—0.3276—pH 7.4, 37 °CPMID 23415904Open
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)Mus musculus7β-hydroxycholesterolhepatic microsomal protein 240–260 μg/mL—3.5—pH 7.4, 37 °CPMID 23415904Open
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)Mus musculuscorticosteronerecombinant protein 14–28 μg/mL—0.00178—37 °CPMID 23415904Open
11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)Mus musculuscorticosteronehepatic microsomal protein 240–260 μg/mL—0.0042—37 °CPMID 23415904Open