CatLogenzyme kinetics catalog

Values CatLog read from this paper

Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme

PMID 14973125doi:10.1074/jbc.m313615200Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 31 records (31 values) from this paper: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) from Golden Syrian hamster, Rattus norvegicus, Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.1.1.146, EC 1.1.1.201

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster11-dehydrocorticosterone500 µM NADPH; recombinant; cell lysate—3.96 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster11-dehydrocorticosterone—7.26 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster11-dehydrocorticosterone400 µM NADPH—4.11 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster3β-hydroxy-5-cholesten-7-one500 µM NADPH; recombinant; cell lysate—3.84 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster3β-hydroxy-5-cholesten-7-one—5.49 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster3β-hydroxy-5-cholesten-7-one400 µM NADPH—4.6 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster5-cholesten-3β,7α-diol500 µM NADP+; recombinant; cell lysate—4.86 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster5-cholesten-3β,7α-diol400 µM NADP+—4.1 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster5-cholesten-3β,7β-diol500 µM NADP+; recombinant; cell lysate—7.29 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamster5-cholesten-3β,7β-diol400 µM NADP+—6.63 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamstercorticosterone500 µM NADP+; recombinant; cell lysate—0.001296—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamstercorticosterone—3.21 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Golden Syrian hamstercorticosterone400 µM NADP+—0.001188—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapiens11-dehydrocorticosterone—3.14 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapiens11-dehydrocorticosterone—5.94 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapiens3β-hydroxy-5-cholesten-7-one—4.87 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapiens3β-hydroxy-5-cholesten-7-one—5.64 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapiens5-cholesten-3β,7β-diol—7.39 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapienscorticosterone—3.05 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Homo sapienscorticosterone—1.65 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone500 µM NADPH; recombinant; cell lysate—3.07 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone—6.81 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone400 µM NADPH—3.63 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one500 µM NADPH; recombinant; cell lysate—4.2 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one—7.76 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one400 µM NADPH—5.72 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus5-cholesten-3β,7β-diol500 µM NADP+; recombinant; cell lysate—7.51 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus5-cholesten-3β,7β-diol400 µM NADP+—7.67 × 10⁻⁴—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone500 µM NADP+; recombinant; cell lysate—0.00117—pH 7.4, 37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone—3.67 × 10⁻⁴—37 °COpen
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone400 µM NADP+—0.001041—pH 7.4, 37 °COpen