CatLogenzyme kinetics catalog

EC 1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP+)

OxidoreductasesOpen in Browse

CatLog read 24 records for EC 1.1.1.201 from 4 papers, for 4 organisms. Names in these papers: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), 7β-hydroxysteroid dehydrogenase (7β-HSDH), 7β-hydroxysteroid dehydrogenase (Ca7β-HSDH).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 39 records for EC 1.1.1.201 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.201 in Browse.

Papers

PaperOrganismsRecords
Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzymeRattus norvegicus11
In search of sustainable chemical processes: cloning, recombinant expression, and functional characterization of the 7α- and 7β-hydroxysteroid dehydrogenases from Clostridium absonumClostridium absonum6
Identification, cloning, heterologous expression, and characterization of a NADPH-dependent 7β-hydroxysteroid dehydrogenase from Collinsella aerofaciensCollinsella aerofaciens5
Contribution of the 7β-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colonRuminococcus gnavus2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone500 µM NADPH; recombinant; cell lysate—3.07 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone—6.81 × 10⁻⁴—37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus11-dehydrocorticosterone400 µM NADPH—3.63 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one500 µM NADPH; recombinant; cell lysate—4.2 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one—7.76 × 10⁻⁴—37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus3β-hydroxy-5-cholesten-7-one400 µM NADPH—5.72 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus5-cholesten-3β,7β-diol500 µM NADP+; recombinant; cell lysate—7.51 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicus5-cholesten-3β,7β-diol400 µM NADP+—7.67 × 10⁻⁴—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone500 µM NADP+; recombinant; cell lysate—0.00117—pH 7.4, 37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone—3.67 × 10⁻⁴—37 °CPMID 14973125Open
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)Rattus norvegicuscorticosterone400 µM NADP+—0.001041—pH 7.4, 37 °CPMID 14973125Open
7β-hydroxysteroid dehydrogenase (7β-HSDH)Collinsella aerofaciens7-keto-lithocholic acid15.850.00523.1 × 10³ calc.pH 8PMID 21181147Open
7β-hydroxysteroid dehydrogenase (7β-HSDH)Collinsella aerofaciensDehydrocholic acid14.590.009231.58 × 10³ calc.pH 8PMID 21181147Open
7β-hydroxysteroid dehydrogenase (7β-HSDH)Collinsella aerofaciensNADP+15.750.005322.96 × 10³ calc.pH 8PMID 21181147Open
7β-hydroxysteroid dehydrogenase (7β-HSDH)Collinsella aerofaciensNADPH17.220.00453.8 × 10³ calc.pH 8PMID 21181147Open
7β-hydroxysteroid dehydrogenase (7β-HSDH)Collinsella aerofaciensursodeoxycholic acid19.660.006233.16 × 10³ calc.pH 8PMID 21181147Open
7β-hydroxysteroid dehydrogenase (7β-HSDH)Ruminococcus gnavus3α,7β-dihydroxy-5β-cholan-24-oic acid (sodium ursodeoxycholate)5.430.9745.5pH 10, 37 °CPMID 23729502Open
7β-hydroxysteroid dehydrogenase (7β-HSDH)Ruminococcus gnavus3α-hydroxy-7-oxo-5β-cholan-24-oic acid (sodium 7-oxo-lithocholate)120.0388300pH 6, 37 °CPMID 23729502Open
7β-hydroxysteroid dehydrogenase (Ca7β-HSDH)Clostridium absonum3α,12α-dihydroxy-7-oxo-5β-cholanoic acid2.03 × 10⁵2.38.81 × 10⁴20 °CPMID 22198717Open
7β-hydroxysteroid dehydrogenase (Ca7β-HSDH)Clostridium absonum3α,7β-dihydroxy-5β-cholan-24-oic acid4.3 × 10⁵3.061.41 × 10⁵20 °CPMID 22198717Open
7β-hydroxysteroid dehydrogenase (Ca7β-HSDH)Clostridium absonum3α-Hydroxy-7,12-dioxo-5β-cholanoic acid4.13 × 10⁵1.52.75 × 10⁵20 °CPMID 22198717Open
7β-hydroxysteroid dehydrogenase (Ca7β-HSDH)Clostridium absonum7-Ketolithocholic acid6.39 × 10⁵2.652.41 × 10⁵20 °CPMID 22198717Open
7β-hydroxysteroid dehydrogenase (Ca7β-HSDH)Clostridium absonumDehydrocholic acid1.46 × 10⁵1.589.24 × 10⁴20 °CPMID 22198717Open
7β-hydroxysteroid dehydrogenase (Ca7β-HSDH)Clostridium absonumUrsocholic acid4.07 × 10⁵2.591.57 × 10⁵20 °CPMID 22198717Open