EC 1.1.1.189: prostaglandin-E2 9-reductase

OxidoreductasesOpen in Browse

CatLog read 81 records for EC 1.1.1.189 from 5 papers, for 3 organisms. Names in these papers: 20α-hydroxysteroid dehydrogenase (AKR1C5), prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase), carbonyl reductase 1 (hCBR1), CBR1 I88 and 2 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 18 records for EC 1.1.1.189 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.189 in Browse.

Papers

Papers with records for EC 1.1.1.189
PaperOrganismsRecords
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenaseOryctolagus cuniculus63
A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinityHomo sapiens8
Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductaseSus scrofa5
Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1Homo sapiens4
Human carbonyl reductase 1 is an S-nitrosoglutathione reductaseHomo sapiens1

Records

Records for EC 1.1.1.189 read from the paper
EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaperOpen record
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus(S)-1-Indanol0.20.1311.53pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), (S)-1-Indanol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus(S)-1-Tetralol0.220.1122pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), (S)-1-Tetralol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus1-Hexanal0.0430.00765.7pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 1-Hexanal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus1-Nonanal0.0329 × 10⁻⁴35pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 1-Nonanal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus17β-Estradiol0.01120.00138.7pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 17β-Estradiol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus2-tert-butyl-1,4-benzoquinone0.180.001180pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 2-tert-butyl-1,4-benzoquinone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus20α-Hydroxyprogesterone0.0480.002222pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 20α-Hydroxyprogesterone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus3-Deoxyglucosone0.181.40.13pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 3-Deoxyglucosone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus4-Androstene-3,17-dione0.0430.00143pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Androstene-3,17-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus4-Chromanol0.0680.1520.45pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Chromanol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus4-Hydroxy-2-nonenal0.00870.00531.63pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Hydroxy-2-nonenal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus4-Nitroacetophenone0.1120.001293pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Nitroacetophenone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus4-Oxo-2-hexenal0.01150.00591.8pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Oxo-2-hexenal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus4-Oxo-2-nonenal0.1120.001862pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Oxo-2-nonenal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus4-Pregnen-3α-ol-20-one0.0320.00132pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Pregnen-3α-ol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5-Androstene-3β,17β-diol0.10.003132pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5-Androstene-3β,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-androstan-17β-ol-3-onereduction; 0.1 mM NADPH; NADPH absorbance; cosubstrate NADPH0.0250.00347.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-androstan-17β-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-androstan-17β-ol-3-oneoxidation; 0.25 mM NADP+; NADPH fluorescence0.0470.0182.7pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-androstan-17β-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Androstan-3α-ol-17-one0.0850.004120pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstan-3α-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Androstan-3β-ol-17-one0.0830.00613.8pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstan-3β-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Androstane-3α,17β-diol0.270.004263pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstane-3α,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Androstane-3β,17β-diol0.0320.002214.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstane-3β,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Pregnan-20α-ol-3-onereduction; 0.1 mM NADPH; NADPH absorbance; cosubstrate NADPH0.0770.005913pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnan-20α-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Pregnan-20α-ol-3-oneoxidation; 0.25 mM NADP+; NADPH fluorescence0.1580.01114.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnan-20α-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Pregnan-3α-ol-20-one0.0320.001325pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnan-3α-ol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Pregnane-3,20-dione0.0185 × 10⁻⁴37pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnane-3,20-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Pregnane-3α,20α-diol0.0258 × 10⁻⁴30pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnane-3α,20α-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5α-Pregnane-3α,21-diol-20-one0.0180.00623pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnane-3α,21-diol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Androstan-17β-ol-3-one0.1530.006225pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstan-17β-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Androstan-3α-ol-17-one0.0670.001740pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstan-3α-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Androstan-3β-ol-17-one0.0450.002816pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstan-3β-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Androstane-3α,17β-diol0.250.0014180pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstane-3α,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Androstane-3β,17β-diol0.0330.002513.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstane-3β,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Pregnan-20α-ol-3-one0.1530.005727pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnan-20α-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Pregnan-3α-ol-20-one0.030.00130pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnan-3α-ol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Pregnane-3,20-dione0.0280.00128pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnane-3,20-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Pregnane-3α,20α-diol0.280.007837pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnane-3α,20α-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus5β-Pregnane-3α,21-diol-20-one0.0170.00266.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnane-3α,21-diol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione0.170.00283pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculus7α-hydroxydehydroepiandrosterone0.0430.002915pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 7α-hydroxydehydroepiandrosterone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusAcetoin0.0970.1621.33pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Acetoin
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusAcrolein0.0350.0142.5pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Acrolein
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusall-trans-Retinal0.00850.00890.95pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), all-trans-Retinal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusBefunolol0.1170.03413.2pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Befunolol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusdehydroepiandrosterone (5-androsten-3β-ol-17-one)0.1550.00627pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), dehydroepiandrosterone (5-androsten-3β-ol-17-one)
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusdehydroepiandrosterone 3-sulfate0.080.004218pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), dehydroepiandrosterone 3-sulfate
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusDiacetyl0.1580.0198.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Diacetyl
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusEstrone0.0170.001115.2pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Estrone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusEstrone-3-sulfate0.0980.006714.7pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Estrone-3-sulfate
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusGeraniol0.0330.180.18pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Geraniol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusIsatin0.1376 × 10⁻⁴230pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Isatin
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusIsocaproaldehyde0.0230.0680.35pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Isocaproaldehyde
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusKetotifen0.020.1110.18pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Ketotifen
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusMenadione0.1250.0182pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Menadione
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusMethylglyoxal0.120.0881.37pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Methylglyoxal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusProgesterone0.0276 × 10⁻⁴45pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Progesterone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusPyridine-3-aldehyde0.1320.0612.2pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Pyridine-3-aldehyde
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusTestosterone0.0570.0134.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Testosterone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculustrans-2-Hexenal0.0250.00743.3pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), trans-2-Hexenal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculustrans-2-Nonenal0.020.00553.7pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), trans-2-Nonenal
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculustrans-Benzene dihydrodiol0.1080.260.42pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), trans-Benzene dihydrodiol
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusα-Tetralone0.0530.0531pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), α-Tetralone
20α-hydroxysteroid dehydrogenase (AKR1C5)Oryctolagus cuniculusβ-Ionol0.230.01810.2pH 7.4, 25 °CPMID 23995665Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), β-Ionol
carbonyl reductase 1 (hCBR1)Homo sapiens4-benzoylpyridine6.70.3618pH 6.5, 25 °CPMID 18493841Open record: carbonyl reductase 1 (hCBR1), 4-benzoylpyridine
carbonyl reductase 1 (hCBR1)Homo sapiens4-nitrobenzaldehyde3.21.32.5pH 6.5, 25 °CPMID 18493841Open record: carbonyl reductase 1 (hCBR1), 4-nitrobenzaldehyde
carbonyl reductase 1 (hCBR1)Homo sapiensmenadione (2-methyl-1,4-naphthoquinone)7.30.028270pH 6.5, 25 °CPMID 18493841Open record: carbonyl reductase 1 (hCBR1), menadione (2-methyl-1,4-naphthoquinone)
carbonyl reductase 1 (hCBR1)Homo sapiensNADPH—0.0062—pH 6.5, 25 °CPMID 18493841Open record: carbonyl reductase 1 (hCBR1), NADPH
CBR1 I88Homo sapiensdaunorubicin610.14440 calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 I88, daunorubicin
CBR1 I88Homo sapiensmenadione850.0551.5 × 10³ calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 I88, menadione
CBR1 I88Homo sapiensNADPH1490.343434 calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 I88, NADPH
CBR1 I88Homo sapiensprostaglandin E2180.3256 calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 I88, prostaglandin E2
CBR1 V88Homo sapiensdaunorubicin910.173530 calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 V88, daunorubicin
CBR1 V88Homo sapiensmenadione1100.0422.6 × 10³ calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 V88, menadione
CBR1 V88Homo sapiensNADPH1790.247725 calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 V88, NADPH
CBR1 V88Homo sapiensprostaglandin E2250.30981 calc.pH 7.4, 37 °CPMID 17344335Open record: CBR1 V88, prostaglandin E2
human carbonyl reductase 1 (hCBR1)Homo sapiensS-nitrosoglutathione7.50.0301249.2pH 6.8PMID 18826943Open record: human carbonyl reductase 1 (hCBR1), S-nitrosoglutathione
prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase)Sus scrofa2-methyl-1,4-naphthoquinone4.750.3115.3pH 6.5, 25 °CPMID 1597188Open record: prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase), 2-methyl-1,4-naphthoquinone
prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase)Sus scrofa4-nitrobenzaldehyde0.970.452.2pH 6.5, 25 °CPMID 1597188Open record: prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase), 4-nitrobenzaldehyde
prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase)Sus scrofa9,10-phenanthrenequinone7.70.00233.3 × 10³pH 6.5, 25 °CPMID 1597188Open record: prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase), 9,10-phenanthrenequinone
prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase)Sus scrofaNADPH—0.0052—pH 6.5, 25 °CPMID 1597188Open record: prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase), NADPH
prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase)Sus scrofaprostaglandin E20.0330.160.208pH 8, 37 °CPMID 1597188Open record: prostaglandin 9-ketoreductase (PG-9-KR; carbonyl reductase), prostaglandin E2