CatLogenzyme kinetics catalog

EC 1.1.1.88: hydroxymethylglutaryl-CoA reductase

OxidoreductasesOpen in Browse

CatLog read 38 records for EC 1.1.1.88 from 3 papers, for 4 organisms. Names in these papers: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase), HMG-CoA reductase (HMGR), HMG-CoA reductase (LjHMGR) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 15 records for EC 1.1.1.88 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.88 in Browse.

Papers

PaperOrganismsRecords
Identification of the catalytically important histidine of 3-hydroxy-3-methylglutaryl-coenzyme A reductasePseudomonas mevalonii18
Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Characterization and chemical modificationPseudomonas mevalonii11
A cofactor-promiscuous HMGR from the Lyme disease pathogen illuminates diversity in bacterial isoprenoid biosynthesisBorrelia burgdorferi, Lactobacillus jensenii and 1 more9

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
3-hydroxy-3-methylglutaryl-coenzyme A reductasePseudomonas mevalonii(R,S)-mevalonate—0.45—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasePseudomonas mevalonii(R,S)-mevalonate—0.32—pH 11, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasePseudomonas mevaloniicoenzyme A—0.05—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasePseudomonas mevaloniicoenzyme A—0.24—pH 11, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasePseudomonas mevaloniiNAD+—0.22—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasePseudomonas mevaloniiNAD+—0.15—pH 11, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381APseudomonas mevalonii(R,S)-mevalonate—0.27—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381APseudomonas mevaloniicoenzyme A—0.03—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381APseudomonas mevaloniiNAD+—0.14—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381KPseudomonas mevalonii(R,S)-mevalonate—0.75—pH 11, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381KPseudomonas mevaloniicoenzyme A—0.5—pH 11, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381KPseudomonas mevaloniiNAD+—1.23—pH 11, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381NPseudomonas mevalonii(R,S)-mevalonate—3.7—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381NPseudomonas mevaloniicoenzyme A—0.2—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381NPseudomonas mevaloniiNAD+—0.81—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381QPseudomonas mevalonii(R,S)-mevalonate—0.71—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381QPseudomonas mevaloniicoenzyme A—0.11—pH 8.1, 37 °CPMID 1634543Open
3-hydroxy-3-methylglutaryl-coenzyme A reductasevariant H381QPseudomonas mevaloniiNAD+—0.62—pH 8.1, 37 °CPMID 1634543Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevalonii(R,S)-3-hydroxy-3-methylglutaryl coenzyme A—0.3—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevalonii(R,S)-mevaldehydeReaction c; 0.48 mM NADH; cosubstrate NADH—36—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevalonii(R,S)-mevaldehydeReaction c*; 1.0 mM CoASH; 0.48 mM NADH; cosubstrate NADH—2.91—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevalonii(R,S)-mevaldehydeReaction d; 1.0 mM CoASH; 3.0 mM NAD+—1.36—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevalonii(R,S)-mevalonate—0.22—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevaloniicoenzyme AReaction a; standard concentrations 3.7 mM (R,S)-mevalonate—0.05—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevaloniicoenzyme AReaction d; standard concentrations 5.0 mM (R,S)-mevaldehyde—0.6—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevaloniiNAD+Reaction a; standard concentrations 3.7 mM (R,S)-mevalonate—0.37—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevaloniiNAD+Reaction d; standard concentrations 5.0 mM (R,S)-mevaldehyde—0.17—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevaloniiNADHReaction b; standard concentrations 1.0 mM (R,S)-HMG-CoA—0.17—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase)Pseudomonas mevaloniiNADHReaction c*; 1.0 mM CoASH; cosubstrate (R,S)-mevaldehyde—0.03—pH 8.1, 37 °CPMID 2681185Open
HMG-CoA reductase (HMGR)Borrelia burgdorferi3-hydroxy-3-methylglutaryl-coenzyme A0.0350.00774.5 calc.pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (HMGR)Borrelia burgdorferiNADH0.01120.07280.150 calc.pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (HMGR)Borrelia burgdorferiNADPH0.0820.02113.9 calc.pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (LjHMGR)Lactobacillus jensenii3-hydroxy-3-methylglutaryl-coenzyme A1.33——pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (LjHMGR)Lactobacillus jenseniiNADH0.692——pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (LjHMGR)Lactobacillus jenseniiNADPH1.365——pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (LpHMGR)Legionella pneumophila3-hydroxy-3-methylglutaryl-coenzyme A0.112——pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (LpHMGR)Legionella pneumophilaNADH0.262——pH 7.5, 30 °CPMID 42615804Open
HMG-CoA reductase (LpHMGR)Legionella pneumophilaNADPH0.127——pH 7.5, 30 °CPMID 42615804Open