EC 1.14.16.1: phenylalanine 4-monooxygenase

OxidoreductasesOpen in Browse

CatLog read 113 records for EC 1.14.16.1 from 9 papers, for 3 organisms. Names in these papers: phenylalanine monooxygenase (hPAH), phenylalanine hydroxylase, phenylalanine hydroxylase (cPAH), l-phenylalanine 4-hydroxylase (CviPAH) and 4 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 92 records for EC 1.14.16.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.16.1 in Browse.

Papers

Papers with records for EC 1.14.16.1
Paper	Organisms	Records
Recombinant heteromeric phenylalanine monooxygenase and the oxygenation of carbon and sulfur substrates	Homo sapiens	36
Further studies of the role of Ser-16 in the regulation of the activity of phenylalanine hydroxylase	Rattus norvegicus	16
Enhancement of L-tryptophan 5-hydroxylation activity by structure-based modification of L-phenylalanine 4-hydroxylase from Chromobacterium violaceum	Chromobacterium violaceum	12
Purification and characterization of phenylalanine 4-monooxygenase from rat liver	Rattus norvegicus	11
Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the…	Homo sapiens	11
The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. Changes in conformation and catalytic properties	Rattus norvegicus	10
A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis	Chromobacterium violaceum	8
An additional substrate binding site in a bacterial phenylalanine hydroxylase	Chromobacterium violaceum	5
Reversing the substrate specificities of phenylalanine and tyrosine hydroxylase: aspartate 425 of tyrosine hydroxylase is essential for L-DOPA formation	Rattus norvegicus	4

Records

Records for EC 1.14.16.1 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
l-phenylalanine 4-hydroxylase (CviPAH)	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	0.2	0.14	1.41	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH), 6,7-dimethyl-5,6,7,8-tetrahydropterine
l-phenylalanine 4-hydroxylase (CviPAH)	Chromobacterium violaceum	l-Phenylalanine	1.93	0.111	17.4	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH), l-Phenylalanine
l-phenylalanine 4-hydroxylase (CviPAH)	Chromobacterium violaceum	l-Tryptophan	0.4	3.44	0.12	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH), l-Tryptophan
l-phenylalanine 4-hydroxylase (CviPAH)variant L101Y	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	0.57	0.099	5.73	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant L101Y, 6,7-dimethyl-5,6,7,8-tetrahydropterine
l-phenylalanine 4-hydroxylase (CviPAH)variant L101Y	Chromobacterium violaceum	l-Phenylalanine	5.83	0.478	12.2	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant L101Y, l-Phenylalanine
l-phenylalanine 4-hydroxylase (CviPAH)variant L101Y	Chromobacterium violaceum	l-Tryptophan	1.02	3.54	0.29	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant L101Y, l-Tryptophan
l-phenylalanine 4-hydroxylase (CviPAH)variant L101Y/W180F	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	0.6	0.086	6.98	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant L101Y/W180F, 6,7-dimethyl-5,6,7,8-tetrahydropterine
l-phenylalanine 4-hydroxylase (CviPAH)variant L101Y/W180F	Chromobacterium violaceum	l-Phenylalanine	0.57	0.253	2.25	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant L101Y/W180F, l-Phenylalanine
l-phenylalanine 4-hydroxylase (CviPAH)variant L101Y/W180F	Chromobacterium violaceum	l-Tryptophan	2.08	4.06	0.51	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant L101Y/W180F, l-Tryptophan
l-phenylalanine 4-hydroxylase (CviPAH)variant W180F	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	0.2	0.035	5.8	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant W180F, 6,7-dimethyl-5,6,7,8-tetrahydropterine
l-phenylalanine 4-hydroxylase (CviPAH)variant W180F	Chromobacterium violaceum	l-Phenylalanine	0.18	0.033	5.44	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant W180F, l-Phenylalanine
l-phenylalanine 4-hydroxylase (CviPAH)variant W180F	Chromobacterium violaceum	l-Tryptophan	0.51	1	0.51	pH 7.5, 30 °C	PMID 19664549	Open record: l-phenylalanine 4-hydroxylase (CviPAH) variant W180F, l-Tryptophan
phenylalanine 4-monooxygenase Form I	Rattus norvegicus	2-amino-4-hydroxy-6,7-dimethyltetrahydropteridinereaction started with pterin; 5 min at 24 °C	—	0.0444	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form I, 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine
phenylalanine 4-monooxygenase Form I	Rattus norvegicus	2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine30 min at 24 °C; 20 mM L-tryptophan	—	0.0714	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form I, 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine
phenylalanine 4-monooxygenase Form I	Rattus norvegicus	2-amino-4-hydroxy-6-methyltetrahydropteridinereaction started with pterin; 5 min at 24 °C	—	0.037	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form I, 2-amino-4-hydroxy-6-methyltetrahydropteridine
phenylalanine 4-monooxygenase Form I	Rattus norvegicus	2-amino-4-hydroxy-6-methyltetrahydropteridine30 min at 24 °C; 20 mM L-tryptophan	—	0.0769	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form I, 2-amino-4-hydroxy-6-methyltetrahydropteridine
phenylalanine 4-monooxygenase Form I	Rattus norvegicus	L-phenylalanine0.4 mM Me2PteH4 as cofactor; cosubstrate Me2PteH4 (0.4 mM)	—	1.92	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form I, L-phenylalanine
phenylalanine 4-monooxygenase Form I	Rattus norvegicus	L-phenylalanine0.4 mM Me2PteH4 as cofactor; cosubstrate Me2PteH4 (0.4 mM)	9.08	—	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form I, L-phenylalanine
phenylalanine 4-monooxygenase Form I	Rattus norvegicus	L-phenylalanine0.4 mM MePteH4 as cofactor; cosubstrate MePteH4 (0.4 mM)	—	0.72	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form I, L-phenylalanine
phenylalanine 4-monooxygenase Form II	Rattus norvegicus	2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine	—	0.0344	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form II, 2-amino-4-hydroxy-6,7-dimethyltetrahydropteridine
phenylalanine 4-monooxygenase Form II	Rattus norvegicus	2-amino-4-hydroxy-6-methyltetrahydropteridine	—	0.0455	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form II, 2-amino-4-hydroxy-6-methyltetrahydropteridine
phenylalanine 4-monooxygenase Form II	Rattus norvegicus	L-phenylalanine0.4 mM Me2PteH4 as cofactor; cosubstrate Me2PteH4 (0.4 mM)	—	1.43	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form II, L-phenylalanine
phenylalanine 4-monooxygenase Form II	Rattus norvegicus	L-phenylalanine0.4 mM MePteH4 as cofactor; cosubstrate MePteH4 (0.4 mM)	—	0.454	—	pH 6.8, 24 °C	PMID 7407194	Open record: phenylalanine 4-monooxygenase Form II, L-phenylalanine
phenylalanine hydroxylase	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0025	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylase	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0046	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylase	Rattus norvegicus	6,7-dimethyltetrahydropterinpurified from rat liver (native enzyme)	—	0.065	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, 6,7-dimethyltetrahydropterin
phenylalanine hydroxylase	Rattus norvegicus	6,7-dimethyltetrahydropterinpurified from rat liver	—	0.105	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, 6,7-dimethyltetrahydropterin
phenylalanine hydroxylase	Rattus norvegicus	6-methyltetrahydropterinpurified from rat liver (native enzyme)	—	0.045	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, 6-methyltetrahydropterin
phenylalanine hydroxylase	Rattus norvegicus	6-methyltetrahydropterinpurified from rat liver	—	0.087	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, 6-methyltetrahydropterin
phenylalanine hydroxylase	Rattus norvegicus	L-phenylalaninepurified from rat liver	—	0.07	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, L-phenylalanine
phenylalanine hydroxylase	Rattus norvegicus	L-phenylalaninewith alpha-tocopherol phosphate (activator)	—	0.07	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, L-phenylalanine
phenylalanine hydroxylase	Rattus norvegicus	L-phenylalanine	—	0.2	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase, L-phenylalanine
phenylalanine hydroxylase	Rattus norvegicus	L-phenylalanine	—	0.187	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase, L-phenylalanine
phenylalanine hydroxylase	Rattus norvegicus	L-tryptophan	—	0.7	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, L-tryptophan
phenylalanine hydroxylase	Rattus norvegicus	tetrahydrobiopterinpurified from rat liver (native enzyme)	—	0.002	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, tetrahydrobiopterin
phenylalanine hydroxylase	Rattus norvegicus	tetrahydrobiopterinpurified from rat liver	—	0.012	—	pH 6.8, 25 °C	PMID 6501308	Open record: phenylalanine hydroxylase, tetrahydrobiopterin
phenylalanine hydroxylase	Rattus norvegicus	tetrahydrobiopterin	—	0.02	—	pH 6.8	PMID 6501308	Open record: phenylalanine hydroxylase, tetrahydrobiopterin
phenylalanine hydroxylasevariant S16A	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0025	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16A, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylasevariant S16A	Rattus norvegicus	L-phenylalanine	—	0.288	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16A, L-phenylalanine
phenylalanine hydroxylasevariant S16D	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0028	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16D, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylasevariant S16D	Rattus norvegicus	L-phenylalanine	—	0.266	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16D, L-phenylalanine
phenylalanine hydroxylasevariant S16E	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0034	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16E, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylasevariant S16E	Rattus norvegicus	L-phenylalanine	—	0.183	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16E, L-phenylalanine
phenylalanine hydroxylasevariant S16K	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0027	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16K, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylasevariant S16K	Rattus norvegicus	L-phenylalanine	—	0.254	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16K, L-phenylalanine
phenylalanine hydroxylasevariant S16N	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0036	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16N, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylasevariant S16N	Rattus norvegicus	L-phenylalanine	—	0.287	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16N, L-phenylalanine
phenylalanine hydroxylasevariant S16Q	Rattus norvegicus	(6R)-5,6,7,8-tetrahydrobiopterin	—	0.0044	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16Q, (6R)-5,6,7,8-tetrahydrobiopterin
phenylalanine hydroxylasevariant S16Q	Rattus norvegicus	L-phenylalanine	—	0.217	—	pH 6.8, 25 °C	PMID 7761394	Open record: phenylalanine hydroxylase variant S16Q, L-phenylalanine
phenylalanine hydroxylase (cPAH)	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	18.6	0.152	130	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH), 6,7-dimethyl-5,6,7,8-tetrahydropterine
phenylalanine hydroxylase (cPAH)	Chromobacterium violaceum	L-phenylalanine	18	0.244	48	pH 7.4, 20 °C	PMID 23860686	Open record: phenylalanine hydroxylase (cPAH), L-phenylalanine
phenylalanine hydroxylase (cPAH)	Chromobacterium violaceum	L-phenylalanine	—	0.244	48	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH), L-phenylalanine
phenylalanine hydroxylase (cPAH)variant D139A	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	0.19	0.254	0.8	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH) variant D139A, 6,7-dimethyl-5,6,7,8-tetrahydropterine
phenylalanine hydroxylase (cPAH)variant D139A	Chromobacterium violaceum	L-phenylalanine	—	0.137	0.59	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH) variant D139A, L-phenylalanine
phenylalanine hydroxylase (cPAH)variant D139E	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	1.9	0.236	9.4	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH) variant D139E, 6,7-dimethyl-5,6,7,8-tetrahydropterine
phenylalanine hydroxylase (cPAH)variant D139E	Chromobacterium violaceum	L-phenylalanine	—	0.225	7.1	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH) variant D139E, L-phenylalanine
phenylalanine hydroxylase (cPAH)variant D139N	Chromobacterium violaceum	6,7-dimethyl-5,6,7,8-tetrahydropterine	1.2	0.262	5.1	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH) variant D139N, 6,7-dimethyl-5,6,7,8-tetrahydropterine
phenylalanine hydroxylase (cPAH)variant D139N	Chromobacterium violaceum	L-phenylalanine	—	0.316	2.8	pH 7.4, 20 °C	PMID 25295853	Open record: phenylalanine hydroxylase (cPAH) variant D139N, L-phenylalanine
phenylalanine hydroxylase (cPAH)variant F258A	Chromobacterium violaceum	L-phenylalanine	10.9	0.4675	14	pH 7.4, 20 °C	PMID 23860686	Open record: phenylalanine hydroxylase (cPAH) variant F258A, L-phenylalanine
phenylalanine hydroxylase (cPAH)variant S203P	Chromobacterium violaceum	L-phenylalanine	4.9	0.6872	5.6	pH 7.4, 20 °C	PMID 23860686	Open record: phenylalanine hydroxylase (cPAH) variant S203P, L-phenylalanine
phenylalanine hydroxylase (cPAH)variant T254A	Chromobacterium violaceum	L-phenylalanine	21.5	0.414	32	pH 7.4, 20 °C	PMID 23860686	Open record: phenylalanine hydroxylase (cPAH) variant T254A, L-phenylalanine
phenylalanine hydroxylase (cPAH)variant Y155A	Chromobacterium violaceum	L-phenylalanine	8.81	0.1365	25	pH 7.4, 20 °C	PMID 23860686	Open record: phenylalanine hydroxylase (cPAH) variant Y155A, L-phenylalanine
phenylalanine hydroxylase (hPAH)	Homo sapiens	(6R)-L-erythro-tetrahydrobiopterintetrameric form (365 kDa) from size-exclusion chromatography	—	0.031	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), (6R)-L-erythro-tetrahydrobiopterin
phenylalanine hydroxylase (hPAH)	Homo sapiens	(6R)-L-erythro-tetrahydrobiopterinTable 4	—	0.025	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), (6R)-L-erythro-tetrahydrobiopterin
phenylalanine hydroxylase (hPAH)	Homo sapiens	(6R)-L-erythro-tetrahydrobiopterinTable 4	—	0.029	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), (6R)-L-erythro-tetrahydrobiopterin
phenylalanine hydroxylase (hPAH)	Homo sapiens	(6R)-L-erythro-tetrahydrobiopterinapproximate Km; in the text	—	0.018	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), (6R)-L-erythro-tetrahydrobiopterin
phenylalanine hydroxylase (hPAH)	Homo sapiens	6-methyl-5,6,7,8-tetrahydropterintetrameric form (365 kDa) from size-exclusion chromatography	—	0.073	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), 6-methyl-5,6,7,8-tetrahydropterin
phenylalanine hydroxylase (hPAH)	Homo sapiens	6-methyl-5,6,7,8-tetrahydropterin	—	0.088	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), 6-methyl-5,6,7,8-tetrahydropterin
phenylalanine hydroxylase (hPAH)	Homo sapiens	L-phenylalanine75 µM (6R)-tetrahydrobiopterin (BH4); cosubstrate BH4	—	0.194	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), L-phenylalanine
phenylalanine hydroxylase (hPAH)	Homo sapiens	L-phenylalanine500 µM 6-methyltetrahydropterin (6-MPH4); cosubstrate 6-MPH4	—	0.504	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), L-phenylalanine
phenylalanine hydroxylase (hPAH)	Homo sapiens	L-phenylalanine75 µM (6R)-tetrahydrobiopterin (BH4); cosubstrate BH4	—	0.236	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), L-phenylalanine
phenylalanine hydroxylase (hPAH)	Homo sapiens	L-phenylalanine75 µM (6R)-tetrahydrobiopterin (BH4); cosubstrate BH4	—	0.175	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), L-phenylalanine
phenylalanine hydroxylase (hPAH)	Homo sapiens	L-phenylalanine500 µM 6-methyltetrahydropterin (6-MPH4); cosubstrate 6-MPH4	—	0.382	—	pH 7, 25 °C	PMID 7887915	Open record: phenylalanine hydroxylase (hPAH), L-phenylalanine
phenylalanine monooxygenase (hPAH)variant wild type (PAHwtLar/PAHwtTet)	Homo sapiens	L-phenylalanine	—	0.1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) variant wild type (PAHwtLar/PAHwtTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)variant wild type (PAHwtLar/PAHwtTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	8	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) variant wild type (PAHwtLar/PAHwtTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)variant wild type (PAHwtTet/PAHwtLar)	Homo sapiens	L-phenylalanine	—	0.1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) variant wild type (PAHwtTet/PAHwtLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)variant wild type (PAHwtTet/PAHwtLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	8	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) variant wild type (PAHwtTet/PAHwtLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/I174T heteromer (PAHwtLar/I174TTet)	Homo sapiens	L-phenylalanine	—	2	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I174T heteromer (PAHwtLar/I174TTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/I174T heteromer (PAHwtLar/I174TTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	19	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I174T heteromer (PAHwtLar/I174TTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/I174T heteromer (PAHwtTet/I174TLar)	Homo sapiens	L-phenylalanine	—	2	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I174T heteromer (PAHwtTet/I174TLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/I174T heteromer (PAHwtTet/I174TLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	20	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I174T heteromer (PAHwtTet/I174TLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/I65T heteromer (PAHwtLar/I65TTet)	Homo sapiens	L-phenylalanine	—	0.1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I65T heteromer (PAHwtLar/I65TTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/I65T heteromer (PAHwtLar/I65TTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	15	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I65T heteromer (PAHwtLar/I65TTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/I65T heteromer (PAHwtTet/I65TLar)	Homo sapiens	L-phenylalanine	—	0.1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I65T heteromer (PAHwtTet/I65TLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/I65T heteromer (PAHwtTet/I65TLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	17	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/I65T heteromer (PAHwtTet/I65TLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R158Q heteromer (PAHwtLar/R158QTet)	Homo sapiens	L-phenylalanine	—	1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R158Q heteromer (PAHwtLar/R158QTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R158Q heteromer (PAHwtLar/R158QTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	20	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R158Q heteromer (PAHwtLar/R158QTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R158Q heteromer (PAHwtTet/R158QLar)	Homo sapiens	L-phenylalanine	—	1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R158Q heteromer (PAHwtTet/R158QLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R158Q heteromer (PAHwtTet/R158QLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	19	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R158Q heteromer (PAHwtTet/R158QLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R261Q heteromer (PAHwtLar/R261QTet)	Homo sapiens	L-phenylalanine	—	1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R261Q heteromer (PAHwtLar/R261QTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R261Q heteromer (PAHwtLar/R261QTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	23	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R261Q heteromer (PAHwtLar/R261QTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R261Q heteromer (PAHwtTet/R261QLar)	Homo sapiens	L-phenylalanine	—	1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R261Q heteromer (PAHwtTet/R261QLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R261Q heteromer (PAHwtTet/R261QLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	21	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R261Q heteromer (PAHwtTet/R261QLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R408W heteromer (PAHwtLar/R408WTet)	Homo sapiens	L-phenylalanine	—	3	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R408W heteromer (PAHwtLar/R408WTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R408W heteromer (PAHwtLar/R408WTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	21	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R408W heteromer (PAHwtLar/R408WTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R408W heteromer (PAHwtTet/R408WLar)	Homo sapiens	L-phenylalanine	—	3	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R408W heteromer (PAHwtTet/R408WLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R408W heteromer (PAHwtTet/R408WLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	20	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R408W heteromer (PAHwtTet/R408WLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R68S heteromer (PAHwtLar/R68STet)	Homo sapiens	L-phenylalanine	—	0.1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R68S heteromer (PAHwtLar/R68STet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R68S heteromer (PAHwtLar/R68STet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	18	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R68S heteromer (PAHwtLar/R68STet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/R68S heteromer (PAHwtTet/R68SLar)	Homo sapiens	L-phenylalanine	—	0.1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R68S heteromer (PAHwtTet/R68SLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/R68S heteromer (PAHwtTet/R68SLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	18	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/R68S heteromer (PAHwtTet/R68SLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/V388M heteromer (PAHwtLar/V388MTet)	Homo sapiens	L-phenylalanine	—	0.9	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/V388M heteromer (PAHwtLar/V388MTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/V388M heteromer (PAHwtLar/V388MTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	25	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/V388M heteromer (PAHwtLar/V388MTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/V388M heteromer (PAHwtTet/V388MLar)	Homo sapiens	L-phenylalanine	—	1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/V388M heteromer (PAHwtTet/V388MLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/V388M heteromer (PAHwtTet/V388MLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	27	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/V388M heteromer (PAHwtTet/V388MLar), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/Y414C heteromer (PAHwtLar/Y414CTet)	Homo sapiens	L-phenylalanine	—	0.2	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/Y414C heteromer (PAHwtLar/Y414CTet), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/Y414C heteromer (PAHwtLar/Y414CTet)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	24	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/Y414C heteromer (PAHwtLar/Y414CTet), S-(carboxymethyl)-L-cysteine
phenylalanine monooxygenase (hPAH)wt/Y414C heteromer (PAHwtTet/Y414CLar)	Homo sapiens	L-phenylalanine	—	0.1	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/Y414C heteromer (PAHwtTet/Y414CLar), L-phenylalanine
phenylalanine monooxygenase (hPAH)wt/Y414C heteromer (PAHwtTet/Y414CLar)	Homo sapiens	S-(carboxymethyl)-L-cysteine	—	22	—	pH 6.8, 37 °C	PMID 21401608	Open record: phenylalanine monooxygenase (hPAH) wt/Y414C heteromer (PAHwtTet/Y414CLar), S-(carboxymethyl)-L-cysteine
tyrosine hydroxylase (TyrH)	Rattus norvegicus	L-phenylalanine	1.6	0.1	16	pH 6.7, 32 °C	PMID 10933781	Open record: tyrosine hydroxylase (TyrH), L-phenylalanine
tyrosine hydroxylase (TyrH)variant D425V	Rattus norvegicus	L-phenylalanine	4.5	0.00125	3.75 × 10³	pH 6.7, 32 °C	PMID 10933781	Open record: tyrosine hydroxylase (TyrH) variant D425V, L-phenylalanine
tyrosine hydroxylase (TyrH)variant H323Y	Rattus norvegicus	L-phenylalanine	7.28	0.0077	947	pH 6.7, 32 °C	PMID 10933781	Open record: tyrosine hydroxylase (TyrH) variant H323Y, L-phenylalanine
tyrosine hydroxylase (TyrH)variant Q310H	Rattus norvegicus	L-phenylalanine	2.03	0.0088	232	pH 6.7, 32 °C	PMID 10933781	Open record: tyrosine hydroxylase (TyrH) variant Q310H, L-phenylalanine