EC 1.4.1.9: leucine dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 133 records for EC 1.4.1.9 from 9 papers, for 8 organisms. Names in these papers: leucine dehydrogenase, leucine dehydrogenase (LaLeuDH), leucine dehydrogenase (BcLeuDH), leucine dehydrogenase (rPsLeuDH) and 4 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 241 records for EC 1.4.1.9 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.4.1.9 in Browse.

Papers

Papers with records for EC 1.4.1.9
Paper	Organisms	Records
doi:10.1016/s1381-1177(03)00093-6	Bacillus stearothermophilus	55
Evidence for lysine 80 as general base catalyst of leucine dehydrogenase	Bacillus stearothermophilus	25
The purification, characterization, cloning and sequencing of the gene for a halostable and thermostable leucine dehydrogenase from Thermoactinomyces intermedius	Thermoactinomyces intermedius	13
doi:10.1002/cctc.202100414	Labrenzia aggregata	12
Enhanced catalytic efficiency and coenzyme affinity of leucine dehydrogenase by comprehensive screening strategy for L-tert-leucine synthesis	Bacillus cereus	10
A Novel Cold-Adapted Leucine Dehydrogenase from Antarctic Sea-Ice Bacterium Pseudoalteromonas sp. ANT178	Pseudoalteromonas sp. ANT178	8
Cloning and Expression of a Novel Leucine Dehydrogenase: Characterization and L-tert-Leucine Production	Exiguobacterium sibiricum	4
Expression of Novel L-Leucine Dehydrogenase and High-Level Production of L-Tert-Leucine Catalyzed by Engineered Escherichia coli	Planifilum fimeticola	4
doi:10.1039/d0cy01373k	Geobacillus stearothermophilus, Thermoactinomyces intermedius	2

Records

Records for EC 1.4.1.9 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
GsAmDHvariant K68S/D261L	Geobacillus stearothermophilus	1-hydroxybutan-2-one	1.79	2.53	0.71	pH 9, 55 °C	doi:10.1039/d0cy01373k	Open record: GsAmDH variant K68S/D261L, 1-hydroxybutan-2-one
leucine dehydrogenase	Bacillus stearothermophilus	4-methyl-2-oxopentanoate	280	0.88	320 calc.	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase, 4-methyl-2-oxopentanoate
leucine dehydrogenase	Bacillus stearothermophilus	ammonia	—	74.8	—	25 °C	PMID 8262941	Open record: leucine dehydrogenase, ammonia
leucine dehydrogenase	Bacillus stearothermophilus	l-Isoleucine	28	2.4	12 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, l-Isoleucine
leucine dehydrogenase	Bacillus stearothermophilus	L-leucineoxidative deamination; 10 mM L-leucine/1.25 mM NAD+ standard	50	5.1	9.8 calc.	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase, L-leucine
leucine dehydrogenase	Bacillus stearothermophilus	L-leucineL-leucine varied 1.5-10 mM; in H2O	39.1	—	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase, L-leucine
leucine dehydrogenase	Bacillus stearothermophilus	L-leucine	29.7	—	—	25 °C	PMID 8262941	Open record: leucine dehydrogenase, L-leucine
leucine dehydrogenase	Bacillus stearothermophilus	l-Leucine	50	5.1	9.8 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, l-Leucine
leucine dehydrogenase	Bacillus stearothermophilus	l-Norleucine	1.3	4.4	0.30 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, l-Norleucine
leucine dehydrogenase	Bacillus stearothermophilus	l-Norvaline	13	7.8	1.7 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, l-Norvaline
leucine dehydrogenase	Bacillus stearothermophilus	NAD+	—	0.063	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase, NAD+
leucine dehydrogenase	Bacillus stearothermophilus	NAD+	—	0.063	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, NAD+
leucine dehydrogenase	Bacillus stearothermophilus	NADH	—	0.035	—	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase, NADH
leucine dehydrogenase	Bacillus stearothermophilus	NADH	—	0.035	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, NADH
leucine dehydrogenase	Bacillus stearothermophilus	α-Keto-iso-caproate	280	0.88	320 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, α-Keto-iso-caproate
leucine dehydrogenase	Bacillus stearothermophilus	α-Keto-β-methyl valerate	280	3.8	74 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, α-Keto-β-methyl valerate
leucine dehydrogenase	Bacillus stearothermophilus	α-Ketocaproate	110	4.7	23 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase, α-Ketocaproate
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	l-Isoleucine	23	7.8	2.9 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, l-Isoleucine
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	l-Leucine	2.8	1.4	2.0 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, l-Leucine
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	l-Norleucine	18	4.1	4.4 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, l-Norleucine
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	l-Norvaline	7.7	27	0.29 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, l-Norvaline
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	l-Phenylalanine	0.8	31	0.026 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, l-Phenylalanine
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	NAD+	—	0.076	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, NAD+
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	NADH	—	0.042	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, NADH
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	Phenylpyruvate	22	7.1	3.1 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, Phenylpyruvate
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	α-Keto-iso-caproate	94	1.7	55 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, α-Keto-iso-caproate
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	α-Keto-β-methyl valerate	235	9.4	25 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, α-Keto-β-methyl valerate
leucine dehydrogenasevariant A113G	Bacillus stearothermophilus	α-Ketocaproate	140	2	70 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G, α-Ketocaproate
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	l-Isoleucine	1.4	33	0.042 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, l-Isoleucine
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	l-Leucine	0.74	35	0.021 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, l-Leucine
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	l-Norleucine	0.6	24	0.025 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, l-Norleucine
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	l-Norvaline	0.29	70	0.0041 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, l-Norvaline
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	l-Phenylalanine	1.4	66	0.021 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, l-Phenylalanine
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	NAD+	—	0.28	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, NAD+
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	NADH	—	0.017	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, NADH
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	Phenylpyruvate	9.9	9.9	1.0 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, Phenylpyruvate
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	α-Keto-iso-caproate	29	30	0.97 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, α-Keto-iso-caproate
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	α-Keto-β-methyl valerate	37	69	0.54 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, α-Keto-β-methyl valerate
leucine dehydrogenasevariant A113G/V291L	Bacillus stearothermophilus	α-Ketocaproate	24	28	0.86 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant A113G/V291L, α-Ketocaproate
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	4-methyl-2-oxopentanoate	250	9.8	26 calc.	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, 4-methyl-2-oxopentanoate
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	L-leucineoxidative deamination; 10 mM L-leucine/1.25 mM NAD+ standard	0.78	—	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, L-leucine
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	L-leucineoxidative deamination; 10 mM L-leucine/1.25 mM NAD+ standard	—	3.7	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, L-leucine
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	L-leucineoxidative deamination; 10 mM L-leucine/1.25 mM NAD+ standard	9.7	—	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, L-leucine
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	L-leucineoxidative deamination; 10 mM L-leucine/1.25 mM NAD+ standard	—	1.2	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, L-leucine
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	L-leucineL-leucine varied 1.5-10 mM; in H2O; apparent kcat	1.17	—	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, L-leucine
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	L-leucine	0.368	—	—	25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, L-leucine
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	NAD+	—	0.14	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, NAD+
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	NAD+in the presence of 1 M ammonia (Table I footnote a)	—	0.041	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, NAD+
leucine dehydrogenasevariant K80A	Bacillus stearothermophilus	NADH	—	0.022	—	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80A, NADH
leucine dehydrogenasevariant K80Q	Bacillus stearothermophilus	4-methyl-2-oxopentanoate	66	25	2.6 calc.	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80Q, 4-methyl-2-oxopentanoate
leucine dehydrogenasevariant K80Q	Bacillus stearothermophilus	L-leucine	0.54	17	0.032 calc.	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80Q, L-leucine
leucine dehydrogenasevariant K80Q	Bacillus stearothermophilus	NAD+	—	0.034	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80Q, NAD+
leucine dehydrogenasevariant K80Q	Bacillus stearothermophilus	NADH	—	0.045	—	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80Q, NADH
leucine dehydrogenasevariant K80R	Bacillus stearothermophilus	4-methyl-2-oxopentanoate	1.7	0.99	1.7 calc.	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80R, 4-methyl-2-oxopentanoate
leucine dehydrogenasevariant K80R	Bacillus stearothermophilus	L-leucine	0.11	2.8	0.039 calc.	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80R, L-leucine
leucine dehydrogenasevariant K80R	Bacillus stearothermophilus	NAD+	—	0.074	—	pH 10.5, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80R, NAD+
leucine dehydrogenasevariant K80R	Bacillus stearothermophilus	NADH	—	0.037	—	pH 9.7, 25 °C	PMID 8262941	Open record: leucine dehydrogenase variant K80R, NADH
leucine dehydrogenasevariant L40D	Bacillus stearothermophilus	l-Isoleucine	0.49	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D, l-Isoleucine
leucine dehydrogenasevariant L40D	Bacillus stearothermophilus	l-Leucine	0.21	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D, l-Leucine
leucine dehydrogenasevariant L40D	Bacillus stearothermophilus	l-Lysine	0.029	64	4.5 × 10⁻⁴ calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D, l-Lysine
leucine dehydrogenasevariant L40D	Bacillus stearothermophilus	l-Norleucine	0.07	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D, l-Norleucine
leucine dehydrogenasevariant L40D	Bacillus stearothermophilus	α-Keto-iso-caproate	9.9	260	0.038 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D, α-Keto-iso-caproate
leucine dehydrogenasevariant L40D	Bacillus stearothermophilus	α-Keto-β-methyl valerate	1.9	47	0.040 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D, α-Keto-β-methyl valerate
leucine dehydrogenasevariant L40D/V294S	Bacillus stearothermophilus	l-Isoleucine	2.8	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D/V294S, l-Isoleucine
leucine dehydrogenasevariant L40D/V294S	Bacillus stearothermophilus	l-Leucine	0.8	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D/V294S, l-Leucine
leucine dehydrogenasevariant L40D/V294S	Bacillus stearothermophilus	l-Lysine	0.45	72	0.0063 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D/V294S, l-Lysine
leucine dehydrogenasevariant L40D/V294S	Bacillus stearothermophilus	l-Norleucine	0.22	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D/V294S, l-Norleucine
leucine dehydrogenasevariant L40D/V294S	Bacillus stearothermophilus	α-Keto-iso-caproate	47	120	0.39 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D/V294S, α-Keto-iso-caproate
leucine dehydrogenasevariant L40D/V294S	Bacillus stearothermophilus	α-Keto-β-methyl valerate	30	110	0.27 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40D/V294S, α-Keto-β-methyl valerate
leucine dehydrogenasevariant L40K	Bacillus stearothermophilus	l-Isoleucine	1.8	64	0.028 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K, l-Isoleucine
leucine dehydrogenasevariant L40K	Bacillus stearothermophilus	l-Leucine	3.8	5.2	0.73 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K, l-Leucine
leucine dehydrogenasevariant L40K	Bacillus stearothermophilus	l-Norleucine	1.9	110	0.017 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K, l-Norleucine
leucine dehydrogenasevariant L40K	Bacillus stearothermophilus	α-Keto-iso-caproate	95	46	2.1 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K, α-Keto-iso-caproate
leucine dehydrogenasevariant L40K	Bacillus stearothermophilus	α-Keto-β-methyl valerate	82	49	1.7 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K, α-Keto-β-methyl valerate
leucine dehydrogenasevariant L40K/V294S	Bacillus stearothermophilus	l-Glutamate	0.02	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K/V294S, l-Glutamate
leucine dehydrogenasevariant L40K/V294S	Bacillus stearothermophilus	l-Isoleucine	17	24	0.71 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K/V294S, l-Isoleucine
leucine dehydrogenasevariant L40K/V294S	Bacillus stearothermophilus	l-Leucine	9.8	26	0.38 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K/V294S, l-Leucine
leucine dehydrogenasevariant L40K/V294S	Bacillus stearothermophilus	l-Norleucine	1.7	27	0.063 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K/V294S, l-Norleucine
leucine dehydrogenasevariant L40K/V294S	Bacillus stearothermophilus	α-Keto-iso-caproate	270	42	6.4 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K/V294S, α-Keto-iso-caproate
leucine dehydrogenasevariant L40K/V294S	Bacillus stearothermophilus	α-Keto-β-methyl valerate	280	84	3.3 calc.		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K/V294S, α-Keto-β-methyl valerate
leucine dehydrogenasevariant L40K/V294S	Bacillus stearothermophilus	α-Ketoglutarate	0.57	—	—		doi:10.1016/s1381-1177(03)00093-6	Open record: leucine dehydrogenase variant L40K/V294S, α-Ketoglutarate
leucine dehydrogenase	Thermoactinomyces intermedius	2-oxobutanoate	—	7.2	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, 2-oxobutanoate
leucine dehydrogenase	Thermoactinomyces intermedius	2-oxohexanoate	—	1.4	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, 2-oxohexanoate
leucine dehydrogenase	Thermoactinomyces intermedius	2-oxopentanoate	—	0.91	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, 2-oxopentanoate
leucine dehydrogenase	Thermoactinomyces intermedius	3-methyl-2-oxobutanoate	—	4.4	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, 3-methyl-2-oxobutanoate
leucine dehydrogenase	Thermoactinomyces intermedius	3-methyl-2-oxopentanoate	—	2.2	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, 3-methyl-2-oxopentanoate
leucine dehydrogenase	Thermoactinomyces intermedius	4-methyl-2-oxopentanoate	—	0.63	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, 4-methyl-2-oxopentanoate
leucine dehydrogenase	Thermoactinomyces intermedius	5,5,5-trifluoro-4-methyl-2-oxopentanoate	—	2.7	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, 5,5,5-trifluoro-4-methyl-2-oxopentanoate
leucine dehydrogenase	Thermoactinomyces intermedius	ammonia	—	118	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, ammonia
leucine dehydrogenase	Thermoactinomyces intermedius	L-isoleucine	—	0.4	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, L-isoleucine
leucine dehydrogenase	Thermoactinomyces intermedius	L-leucine	—	2	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, L-leucine
leucine dehydrogenase	Thermoactinomyces intermedius	L-valine	—	2.4	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, L-valine
leucine dehydrogenase	Thermoactinomyces intermedius	NAD+	—	0.36	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, NAD+
leucine dehydrogenase	Thermoactinomyces intermedius	NADH	—	0.042	—	37 °C	PMID 8020469	Open record: leucine dehydrogenase, NADH
leucine dehydrogenase (BcLeuDH)	Bacillus cereus	NADH	33.71	0.28	118.5	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH), NADH
leucine dehydrogenase (BcLeuDH)	Bacillus cereus	trimethylpyruvate	94.14	60.82	1.55	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH), trimethylpyruvate
leucine dehydrogenase (BcLeuDH)variant D126E	Bacillus cereus	NADH	50.92	0.27	188.6	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant D126E, NADH
leucine dehydrogenase (BcLeuDH)variant D126E	Bacillus cereus	trimethylpyruvate	77.36	23.17	3.34	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant D126E, trimethylpyruvate
leucine dehydrogenase (BcLeuDH)variant E116V	Bacillus cereus	NADH	60.48	0.25	241.9	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant E116V, NADH
leucine dehydrogenase (BcLeuDH)variant E116V	Bacillus cereus	trimethylpyruvate	60.49	10.74	5.63	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant E116V, trimethylpyruvate
leucine dehydrogenase (BcLeuDH)variant E24A/D126E	Bacillus cereus	NADH	42.62	0.154	276.8	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant E24A/D126E, NADH
leucine dehydrogenase (BcLeuDH)variant E24A/D126E	Bacillus cereus	trimethylpyruvate	93.27	17.57	5.31	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant E24A/D126E, trimethylpyruvate
leucine dehydrogenase (BcLeuDH)variant E24V/E116V	Bacillus cereus	NADH	35.09	0.1	350.9	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant E24V/E116V, NADH
leucine dehydrogenase (BcLeuDH)variant E24V/E116V	Bacillus cereus	trimethylpyruvate	66.21	7.92	8.36	pH 8.5, 30 °C	PMID 33929595	Open record: leucine dehydrogenase (BcLeuDH) variant E24V/E116V, trimethylpyruvate
leucine dehydrogenase (EsiLeuDH)	Exiguobacterium sibiricum	L-leucine	4.31	0.88	4.9	pH 9.5, 30 °C	PMID 32296684	Open record: leucine dehydrogenase (EsiLeuDH), L-leucine
leucine dehydrogenase (EsiLeuDH)	Exiguobacterium sibiricum	NAD+	8.41	1.46	5.76	pH 9.5, 30 °C	PMID 32296684	Open record: leucine dehydrogenase (EsiLeuDH), NAD+
leucine dehydrogenase (EsiLeuDH)	Exiguobacterium sibiricum	NADH	76.86	0.624	123.2	pH 8.5, 30 °C	PMID 32296684	Open record: leucine dehydrogenase (EsiLeuDH), NADH
leucine dehydrogenase (EsiLeuDH)	Exiguobacterium sibiricum	trimethylpyruvic acid	45.43	5.96	7.62	pH 8.5, 30 °C	PMID 32296684	Open record: leucine dehydrogenase (EsiLeuDH), trimethylpyruvic acid
leucine dehydrogenase (LaLeuDH)	Labrenzia aggregata	L-tert-leucine	33.9	5.05	6.7	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH), L-tert-leucine
leucine dehydrogenase (LaLeuDH)	Labrenzia aggregata	NAD+	—	0.078	434.6	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH), NAD+
leucine dehydrogenase (LaLeuDH)	Labrenzia aggregata	NADH	—	0.43	807.7	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH), NADH
leucine dehydrogenase (LaLeuDH)	Labrenzia aggregata	trimethylpyruvic acid	347.3	0.096	3.62 × 10³	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH), trimethylpyruvic acid
leucine dehydrogenase (LaLeuDH)variant D153N	Labrenzia aggregata	NADH	—	0.038	15,013	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant D153N, NADH
leucine dehydrogenase (LaLeuDH)variant D153N	Labrenzia aggregata	trimethylpyruvic acid	570.5	0.119	4794	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant D153N, trimethylpyruvic acid
leucine dehydrogenase (LaLeuDH)variant D153N/H191N	Labrenzia aggregata	NADH	—	0.017	40,465	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant D153N/H191N, NADH
leucine dehydrogenase (LaLeuDH)variant D153N/H191N	Labrenzia aggregata	trimethylpyruvic acid	687.9	0.096	7166	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant D153N/H191N, trimethylpyruvic acid
leucine dehydrogenase (LaLeuDH)variant H191N	Labrenzia aggregata	NADH	—	0.072	7936	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant H191N, NADH
leucine dehydrogenase (LaLeuDH)variant H191N	Labrenzia aggregata	trimethylpyruvic acid	571.4	0.095	6015	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant H191N, trimethylpyruvic acid
leucine dehydrogenase (LaLeuDH)variant P130V	Labrenzia aggregata	NADH	—	0.05	12,348	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant P130V, NADH
leucine dehydrogenase (LaLeuDH)variant P130V	Labrenzia aggregata	trimethylpyruvic acid	617.4	0.3	2058	pH 8, 30 °C	doi:10.1002/cctc.202100414	Open record: leucine dehydrogenase (LaLeuDH) variant P130V, trimethylpyruvic acid
leucine dehydrogenase (PfLeuDH)	Planifilum fimeticola	3,3-dimethyl-2-oxobutanoate	39.07	3.08	12.69	pH 9.5, 30 °C	PMID 33859982	Open record: leucine dehydrogenase (PfLeuDH), 3,3-dimethyl-2-oxobutanoate
leucine dehydrogenase (PfLeuDH)	Planifilum fimeticola	L-Leucine	2.33	0.1	23.3	pH 9.5, 30 °C	PMID 33859982	Open record: leucine dehydrogenase (PfLeuDH), L-Leucine
leucine dehydrogenase (PfLeuDH)	Planifilum fimeticola	NAD+	1.81	0.11	16.45	pH 9.5, 30 °C	PMID 33859982	Open record: leucine dehydrogenase (PfLeuDH), NAD+
leucine dehydrogenase (PfLeuDH)	Planifilum fimeticola	NADH	6.06	0.06	101	pH 9.5, 30 °C	PMID 33859982	Open record: leucine dehydrogenase (PfLeuDH), NADH
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	DL-methionine	16.57	0.75	22.09	pH 10.4, 30 °C	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), DL-methionine
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	L-arginine	14.09	0.84	16.77	pH 10.4, 30 °C	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), L-arginine
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	L-leucine	30.13	0.33	91.3	pH 10.4, 30 °C	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), L-leucine
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	L-leucine	12.25	—	—	pH 10.4	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), L-leucine
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	L-leucine	14.96	—	—	pH 10.4, 10 °C	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), L-leucine
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	L-leucine	20.2	—	—	pH 10.4, 20 °C	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), L-leucine
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	L-proline	20.8	0.64	32.5	pH 10.4, 30 °C	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), L-proline
leucine dehydrogenase (rPsLeuDH)	Pseudoalteromonas sp. ANT178	L-tyrosine	26.39	0.48	54.98	pH 10.4, 30 °C	PMID 30275355	Open record: leucine dehydrogenase (rPsLeuDH), L-tyrosine
TiAmDHvariant K68S/N261L	Thermoactinomyces intermedius	1-hydroxybutan-2-one	0.32	3.64	0.09	pH 8.5, 45 °C	doi:10.1039/d0cy01373k	Open record: TiAmDH variant K68S/N261L, 1-hydroxybutan-2-one