CatLogenzyme kinetics catalog

EC 1.6.4.5: thioredoxin reductase (NADPH)

OxidoreductasesOpen in Browse

CatLog read 6 records for EC 1.6.4.5 from 1 paper, for 1 organism. Names in these papers: thioredoxin reductase (PfTrxR).

EC 1.6.4.5 is no longer current; BRENDA: “transferred to EC 1.8.1.9”.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

Papers

PaperOrganismsRecords
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductasePlasmodium falciparum6

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
thioredoxin reductase (PfTrxR)Plasmodium falciparum1,4-naphthoquinone12.50.0694180.1pH 7.4, 25 °CPMID 18633531Open
thioredoxin reductase (PfTrxR)Plasmodium falciparum2,3-dimethylquinoxaline-5,8-dione9.230.051181pH 7.4, 25 °CPMID 18633531Open
thioredoxin reductase (PfTrxR)Plasmodium falciparum6-methylquinoline-5,8-dione67.350.6054111.2pH 7.4, 25 °CPMID 18633531Open
thioredoxin reductase (PfTrxR)Plasmodium falciparummenadione30.70.188163.5pH 7.4, 25 °CPMID 18633531Open
thioredoxin reductase (PfTrxR)Plasmodium falciparumquinoline-5,8-dione30.250.0783386.3pH 7.4, 25 °CPMID 18633531Open
thioredoxin reductase (PfTrxR)Plasmodium falciparumquinoxaline-5,8-dione6.250.0286218.3pH 7.4, 25 °CPMID 18633531Open