Values CatLog read from this paper
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase
PMID 18633531doi:10.1039/b802649cOpen in Browse
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CatLog read 18 records (54 values) from this paper: glutathione reductase (hGR), glutathione reductase (PfGR), thioredoxin reductase (PfTrxR) from Plasmodium falciparum, Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| glutathione reductase (hGR) | Homo sapiens | 1,4-naphthoquinone | 1.08 | 0.1581 | 6.8 | pH 6.9, 25 °C | Open record: glutathione reductase (hGR), 1,4-naphthoquinone |
| glutathione reductase (hGR) | Homo sapiens | 6,7-dimethylquinoline-5,8-dione | 0.11 | 0.413 | 0.27 | pH 6.9, 25 °C | Open record: glutathione reductase (hGR), 6,7-dimethylquinoline-5,8-dione |
| glutathione reductase (hGR) | Homo sapiens | 6-methylquinoline-5,8-dione | 0.35 | 0.4208 | 0.83 | pH 6.9, 25 °C | Open record: glutathione reductase (hGR), 6-methylquinoline-5,8-dione |
| glutathione reductase (hGR) | Homo sapiens | 7-methylquinoline-5,8-dione | 0.13 | 0.2245 | 0.58 | pH 6.9, 25 °C | Open record: glutathione reductase (hGR), 7-methylquinoline-5,8-dione |
| glutathione reductase (hGR) | Homo sapiens | quinoline-5,8-dione | 2.23 | 0.3635 | 6.13 | pH 6.9, 25 °C | Open record: glutathione reductase (hGR), quinoline-5,8-dione |
| glutathione reductase (hGR) | Homo sapiens | quinoxaline-5,8-dione | 0.34 | 0.0595 | 5.71 | pH 6.9, 25 °C | Open record: glutathione reductase (hGR), quinoxaline-5,8-dione |
| glutathione reductase (PfGR) | Plasmodium falciparum | 1,4-naphthoquinone | 1.08 | 0.1721 | 6.3 | pH 6.9, 25 °C | Open record: glutathione reductase (PfGR), 1,4-naphthoquinone |
| glutathione reductase (PfGR) | Plasmodium falciparum | 6,7-dimethylquinoline-5,8-dione | 0.08 | 0.0858 | 0.99 | pH 6.9, 25 °C | Open record: glutathione reductase (PfGR), 6,7-dimethylquinoline-5,8-dione |
| glutathione reductase (PfGR) | Plasmodium falciparum | 6-methylquinoline-5,8-dione | 0.35 | 0.4104 | 0.83 | pH 6.9, 25 °C | Open record: glutathione reductase (PfGR), 6-methylquinoline-5,8-dione |
| glutathione reductase (PfGR) | Plasmodium falciparum | 7-methylquinoline-5,8-dione | 0.39 | 0.4044 | 0.96 | pH 6.9, 25 °C | Open record: glutathione reductase (PfGR), 7-methylquinoline-5,8-dione |
| glutathione reductase (PfGR) | Plasmodium falciparum | quinoline-5,8-dione | 1.55 | 0.2344 | 6.61 | pH 6.9, 25 °C | Open record: glutathione reductase (PfGR), quinoline-5,8-dione |
| glutathione reductase (PfGR) | Plasmodium falciparum | quinoxaline-5,8-dione | 0.35 | 0.0562 | 6.2 | pH 6.9, 25 °C | Open record: glutathione reductase (PfGR), quinoxaline-5,8-dione |
| thioredoxin reductase (PfTrxR) | Plasmodium falciparum | 1,4-naphthoquinone | 12.5 | 0.0694 | 180.1 | pH 7.4, 25 °C | Open record: thioredoxin reductase (PfTrxR), 1,4-naphthoquinone |
| thioredoxin reductase (PfTrxR) | Plasmodium falciparum | 2,3-dimethylquinoxaline-5,8-dione | 9.23 | 0.051 | 181 | pH 7.4, 25 °C | Open record: thioredoxin reductase (PfTrxR), 2,3-dimethylquinoxaline-5,8-dione |
| thioredoxin reductase (PfTrxR) | Plasmodium falciparum | 6-methylquinoline-5,8-dione | 67.35 | 0.6054 | 111.2 | pH 7.4, 25 °C | Open record: thioredoxin reductase (PfTrxR), 6-methylquinoline-5,8-dione |
| thioredoxin reductase (PfTrxR) | Plasmodium falciparum | menadione | 30.7 | 0.188 | 163.5 | pH 7.4, 25 °C | Open record: thioredoxin reductase (PfTrxR), menadione |
| thioredoxin reductase (PfTrxR) | Plasmodium falciparum | quinoline-5,8-dione | 30.25 | 0.0783 | 386.3 | pH 7.4, 25 °C | Open record: thioredoxin reductase (PfTrxR), quinoline-5,8-dione |
| thioredoxin reductase (PfTrxR) | Plasmodium falciparum | quinoxaline-5,8-dione | 6.25 | 0.0286 | 218.3 | pH 7.4, 25 °C | Open record: thioredoxin reductase (PfTrxR), quinoxaline-5,8-dione |