EC 1.8.1.7: glutathione-disulfide reductase

OxidoreductasesOpen in Browse

CatLog read 56 records for EC 1.8.1.7 from 6 papers, for 6 organisms. Names in these papers: glutathione reductase (PfGR), glutathione reductase (PmGR), glutathione reductase, glutathione reductase (hGR) and 2 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 103 records for EC 1.8.1.7 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.8.1.7 in Browse.

Papers

Papers with records for EC 1.8.1.7
Paper	Organisms	Records
Antiplasmodial activity of quinones: roles of aziridinyl substituents and the inhibition of Plasmodium falciparum glutathione reductase	Homo sapiens, Plasmodium falciparum	29
The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase	Homo sapiens, Plasmodium falciparum	12
Aromatic Residue F443 Modulates the Dimer Interface and Activity of Pseudomonas mandelii Glutathione Reductase	Pseudomonas mandelii	7
Quantifying the Characteristic Turnover Frequency of an Individual Redox Enzyme via Real-Time Electrical Transduction of Catalytic Events in a Label-Free Single-Protein Junction	Saccharomyces cerevisiae	4
Control of the NADPH supply and GSH recycling for oxidative stress management in hepatoma and liver mitochondria	Rattus norvegicus	2
Exploring the Potential of Glutathione Reductase Overexpression to Improve Tellurium Nanoparticle Production in Escherichia coli	Escherichia coli	2

Records

Records for EC 1.8.1.7 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
glutathione reductase	Escherichia coli	beta-nicotinamide adenine dinucleotide phosphate, reduced form	50.9	0.0127	4 × 10³	pH 7, 37 °C	PMID 40004015	Open record: glutathione reductase, beta-nicotinamide adenine dinucleotide phosphate, reduced form
glutathione reductase	Escherichia coli	oxidized glutathione	47.3	0.0825	570	pH 7, 37 °C	PMID 40004015	Open record: glutathione reductase, oxidized glutathione
glutathione reductase	Saccharomyces cerevisiae	oxidized glutathione	242.9	—	—	pH 7	PMID 42584624	Open record: glutathione reductase, oxidized glutathione
glutathione reductase	Saccharomyces cerevisiae	oxidized glutathioneapproximate kcat; kcat per dimer	243	—	—	pH 8, 25 °C	PMID 42584624	Open record: glutathione reductase, oxidized glutathione
glutathione reductase	Saccharomyces cerevisiae	oxidized glutathioneapproximate kcat; kcat per subunit	122	—	—	pH 8, 25 °C	PMID 42584624	Open record: glutathione reductase, oxidized glutathione
glutathione reductase	Saccharomyces cerevisiae	oxidized glutathione	—	0.086	—	pH 8, 25 °C	PMID 42584624	Open record: glutathione reductase, oxidized glutathione
glutathione reductase (GR)	Rattus norvegicus	oxidized glutathionemitochondria isolated from AS-30D rat hepatoma cells	—	0.053	—	pH 7.2, 37 °C	PMID 30053395	Open record: glutathione reductase (GR), oxidized glutathione
glutathione reductase (GR)	Rattus norvegicus	oxidized glutathionerat liver mitochondria	—	0.046	—	pH 7.2, 37 °C	PMID 30053395	Open record: glutathione reductase (GR), oxidized glutathione
glutathione reductase (hGR)	Homo sapiens	1,4-naphthoquinone	1.08	0.1581	6.8	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (hGR), 1,4-naphthoquinone
glutathione reductase (hGR)	Homo sapiens	6,7-dimethylquinoline-5,8-dione	0.11	0.413	0.27	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (hGR), 6,7-dimethylquinoline-5,8-dione
glutathione reductase (hGR)	Homo sapiens	6-methylquinoline-5,8-dione	0.35	0.4208	0.83	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (hGR), 6-methylquinoline-5,8-dione
glutathione reductase (hGR)	Homo sapiens	7-methylquinoline-5,8-dione	0.13	0.2245	0.58	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (hGR), 7-methylquinoline-5,8-dione
glutathione reductase (hGR)	Homo sapiens	quinoline-5,8-dione	2.23	0.3635	6.13	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (hGR), quinoline-5,8-dione
glutathione reductase (hGR)	Homo sapiens	quinoxaline-5,8-dione	0.34	0.0595	5.71	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (hGR), quinoxaline-5,8-dione
glutathione reductase (HGR), human erythrocyte	Homo sapiens	GSSG	190	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (HGR), human erythrocyte, GSSG
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Dihydroxy-9,10-anthraquinone	0.11	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Dihydroxy-9,10-anthraquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Dihydroxy-9,10-anthraquinonequinone-mediated cytochrome c reduction assay	0.1	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Dihydroxy-9,10-anthraquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Dihydroxy-9,10-anthraquinone	—	—	3.2	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Dihydroxy-9,10-anthraquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Dihydroxy-9,10-anthraquinonequinone-mediated cytochrome c reduction assay	—	—	3	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Dihydroxy-9,10-anthraquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-naphthoquinone	1.08	0.1721	6.3	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (PfGR), 1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Naphthoquinone	1	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Naphthoquinonequinone-mediated cytochrome c reduction assay	1.1	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Naphthoquinone	—	—	5.2	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,4-Naphthoquinonequinone-mediated cytochrome c reduction assay	—	—	5.7	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,4-Naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	1,8-Dihydroxy-9,10-anthraquinone	—	—	0.37	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 1,8-Dihydroxy-9,10-anthraquinone
glutathione reductase (PfGR)	Plasmodium falciparum	2,6-Dimethyl-1,4-benzoquinone	1.1	—	6.5	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 2,6-Dimethyl-1,4-benzoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	2-Methyl-1,4-naphthoquinone	0.14	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 2-Methyl-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	2-Methyl-1,4-naphthoquinonequinone-mediated cytochrome c reduction assay	0.17	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 2-Methyl-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	2-Methyl-1,4-naphthoquinone	—	—	1.8	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 2-Methyl-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	2-Methyl-1,4-naphthoquinonequinone-mediated cytochrome c reduction assay	—	—	2	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 2-Methyl-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	5,8-Dihydroxy-1,4-naphthoquinone	7	—	430	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 5,8-Dihydroxy-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	5-Hydroxy-1,4-naphthoquinone	5.5	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 5-Hydroxy-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	5-Hydroxy-1,4-naphthoquinonequinone-mediated cytochrome c reduction assay	5.7	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 5-Hydroxy-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	5-Hydroxy-1,4-naphthoquinone	—	—	360	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 5-Hydroxy-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	5-Hydroxy-1,4-naphthoquinonequinone-mediated cytochrome c reduction assay	—	—	400	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 5-Hydroxy-1,4-naphthoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	6,7-dimethylquinoline-5,8-dione	0.08	0.0858	0.99	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (PfGR), 6,7-dimethylquinoline-5,8-dione
glutathione reductase (PfGR)	Plasmodium falciparum	6-methylquinoline-5,8-dione	0.35	0.4104	0.83	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (PfGR), 6-methylquinoline-5,8-dione
glutathione reductase (PfGR)	Plasmodium falciparum	7-methylquinoline-5,8-dione	0.39	0.4044	0.96	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (PfGR), 7-methylquinoline-5,8-dione
glutathione reductase (PfGR)	Plasmodium falciparum	9,10-Phenanthrene quinone	0.22	—	4.2	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), 9,10-Phenanthrene quinone
glutathione reductase (PfGR)	Plasmodium falciparum	AZQ	—	—	0.75	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), AZQ
glutathione reductase (PfGR)	Plasmodium falciparum	DZQ	5	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), DZQ
glutathione reductase (PfGR)	Plasmodium falciparum	DZQquinone-mediated cytochrome c reduction assay	5.3	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), DZQ
glutathione reductase (PfGR)	Plasmodium falciparum	DZQ	—	—	40	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), DZQ
glutathione reductase (PfGR)	Plasmodium falciparum	DZQquinone-mediated cytochrome c reduction assay	—	—	45	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), DZQ
glutathione reductase (PfGR)	Plasmodium falciparum	GSSG	145	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), GSSG
glutathione reductase (PfGR)	Plasmodium falciparum	quinoline-5,8-dione	1.55	0.2344	6.61	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (PfGR), quinoline-5,8-dione
glutathione reductase (PfGR)	Plasmodium falciparum	quinoxaline-5,8-dione	0.35	0.0562	6.2	pH 6.9, 25 °C	PMID 18633531	Open record: glutathione reductase (PfGR), quinoxaline-5,8-dione
glutathione reductase (PfGR)	Plasmodium falciparum	Tetramethyl-1,4-benzoquinone	0.3	—	1	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), Tetramethyl-1,4-benzoquinone
glutathione reductase (PfGR)	Plasmodium falciparum	Trimethyl-1,4-benzoquinone	0.2	—	—	pH 7, 25 °C	PMID 19919822	Open record: glutathione reductase (PfGR), Trimethyl-1,4-benzoquinone
glutathione reductase (PmGR)	Pseudomonas mandelii	glutathione disulfide	138.3	0.0044	3.12 × 10⁴	pH 7.5, 50 °C	PMID 40060842	Open record: glutathione reductase (PmGR), glutathione disulfide
glutathione reductase (PmGR)variant F443A	Pseudomonas mandelii	glutathione disulfide	19.4	0.0789	200	pH 7.5, 30 °C	PMID 40060842	Open record: glutathione reductase (PmGR) variant F443A, glutathione disulfide
glutathione reductase (PmGR)variant F443L	Pseudomonas mandelii	glutathione disulfide	117.4	0.0052	2.25 × 10⁴	pH 7.5, 40 °C	PMID 40060842	Open record: glutathione reductase (PmGR) variant F443L, glutathione disulfide
glutathione reductase (PmGR)variant L416A	Pseudomonas mandelii	glutathione disulfide	12.9	0.1549	100	pH 7.5, 40 °C	PMID 40060842	Open record: glutathione reductase (PmGR) variant L416A, glutathione disulfide
glutathione reductase (PmGR)variant L416E	Pseudomonas mandelii	glutathione disulfide	11.8	0.1495	100	pH 7.5, 40 °C	PMID 40060842	Open record: glutathione reductase (PmGR) variant L416E, glutathione disulfide
glutathione reductase (PmGR)variant L416F	Pseudomonas mandelii	glutathione disulfide	11.7	0.1558	500	pH 7.5, 40 °C	PMID 40060842	Open record: glutathione reductase (PmGR) variant L416F, glutathione disulfide
glutathione reductase (PmGR)variant L416Q	Pseudomonas mandelii	glutathione disulfide	43.3	0.0265	1.6 × 10³	pH 7.5, 40 °C	PMID 40060842	Open record: glutathione reductase (PmGR) variant L416Q, glutathione disulfide