EC 1.6.99.7: dihydropteridine reductase
OxidoreductasesOpen in Browse
CatLog read 32 records for EC 1.6.99.7 from 2 papers, for 1 organism. Names in these papers: dihydropteridine reductase (DHPR).
EC 1.6.99.7 is no longer current; BRENDA: “transferred to EC 1.5.1.34”.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
Papers
| Paper | Organisms | Records |
|---|---|---|
| The comparative interaction of quinonoid (6R)-dihydrobiopterin and an alternative dihydropterin substrate with wild-type and mutant rat dihydropteridine reductases | Rattus norvegicus | 24 |
| Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement | Rattus norvegicus | 8 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| dihydropteridine reductase (DHPR) | Rattus norvegicus | NADH | — | 0.005 | 4.6 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR), NADH |
| dihydropteridine reductase (DHPR) | Rattus norvegicus | quinonoid (6R)-L-erythro-dihydrobiopterin | 23 | 4 × 10⁻⁴ | 5.75 × 10⁴ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR), quinonoid (6R)-L-erythro-dihydrobiopterin |
| dihydropteridine reductase (DHPR) | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridinecosubstrate NADH | — | 0.027 | — | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR), quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR) | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridinecosubstrate NADPH | — | 0.038 | — | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR), quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR) | Rattus norvegicus | reduced nicotinamide adenine dinucleotide | 152 | 0.013 | 1.2 × 10⁴ | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR), reduced nicotinamide adenine dinucleotide |
| dihydropteridine reductase (DHPR) | Rattus norvegicus | reduced nicotinamide adenine dinucleotide phosphate | 37 | 0.15 | 250 | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR), reduced nicotinamide adenine dinucleotide phosphate |
| dihydropteridine reductase (DHPR)variant A133S | Rattus norvegicus | NADHcosubstrate q-6,7-diMePtH2 | — | 0.022 | 6.9 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant A133S, NADH |
| dihydropteridine reductase (DHPR)variant A133S | Rattus norvegicus | NADHcosubstrate qBH2 | — | 0.004 | 5 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant A133S, NADH |
| dihydropteridine reductase (DHPR)variant A133S | Rattus norvegicus | quinonoid (6R)-L-erythro-dihydrobiopterin | 20 | 4 × 10⁻⁴ | 5 × 10⁴ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant A133S, quinonoid (6R)-L-erythro-dihydrobiopterin |
| dihydropteridine reductase (DHPR)variant A133S | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridine | 152 | 0.008 | 1.9 × 10⁴ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant A133S, quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR)variant D37I | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridinecosubstrate NADH | — | 0.03 | — | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR) variant D37I, quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR)variant D37I | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridinecosubstrate NADPH | — | 0.043 | — | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR) variant D37I, quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR)variant D37I | Rattus norvegicus | reduced nicotinamide adenine dinucleotide | 42 | 0.036 | 1.2 × 10³ | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR) variant D37I, reduced nicotinamide adenine dinucleotide |
| dihydropteridine reductase (DHPR)variant D37I | Rattus norvegicus | reduced nicotinamide adenine dinucleotide phosphate | 26 | 0.44 | 60 | pH 6.8 | PMID 1639779 | Open record: dihydropteridine reductase (DHPR) variant D37I, reduced nicotinamide adenine dinucleotide phosphate |
| dihydropteridine reductase (DHPR)variant K150Q | Rattus norvegicus | NADHcosubstrate q-6,7-diMePtH2 | — | 0.013 | 4 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant K150Q, NADH |
| dihydropteridine reductase (DHPR)variant K150Q | Rattus norvegicus | NADHcosubstrate qBH2 | — | 0.079 | 3.4 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant K150Q, NADH |
| dihydropteridine reductase (DHPR)variant K150Q | Rattus norvegicus | quinonoid (6R)-L-erythro-dihydrobiopterin | 269 | 0.028 | 9.6 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant K150Q, quinonoid (6R)-L-erythro-dihydrobiopterin |
| dihydropteridine reductase (DHPR)variant K150Q | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridine | 52 | 0.29 | 200 | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant K150Q, quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR)variant Y146F | Rattus norvegicus | NADHcosubstrate q-6,7-diMePtH2 | — | 0.003 | 5.7 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F, NADH |
| dihydropteridine reductase (DHPR)variant Y146F | Rattus norvegicus | NADHcosubstrate qBH2 | — | 0.051 | 2.7 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F, NADH |
| dihydropteridine reductase (DHPR)variant Y146F | Rattus norvegicus | quinonoid (6R)-L-erythro-dihydrobiopterin | 138 | 0.308 | 500 | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F, quinonoid (6R)-L-erythro-dihydrobiopterin |
| dihydropteridine reductase (DHPR)variant Y146F | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridine | 17 | 0.46 | 40 | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F, quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR)variant Y146F/A133S | Rattus norvegicus | NADHcosubstrate q-6,7-diMePtH2 | — | 0.002 | 1 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F/A133S, NADH |
| dihydropteridine reductase (DHPR)variant Y146F/A133S | Rattus norvegicus | NADHcosubstrate qBH2 | — | 0.008 | 9.3 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F/A133S, NADH |
| dihydropteridine reductase (DHPR)variant Y146F/A133S | Rattus norvegicus | quinonoid (6R)-L-erythro-dihydrobiopterin | 74 | 0.024 | 3.1 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F/A133S, quinonoid (6R)-L-erythro-dihydrobiopterin |
| dihydropteridine reductase (DHPR)variant Y146F/A133S | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridine | 2 | 0.1 | 20 | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F/A133S, quinonoid 6,7-dimethyldihydropteridine |
| dihydropteridine reductase (DHPR)variant Y146F/K150Q | Rattus norvegicus | NADH | — | 0.02 | 1 × 10⁴ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F/K150Q, NADH |
| dihydropteridine reductase (DHPR)variant Y146F/K150Q | Rattus norvegicus | quinonoid (6R)-L-erythro-dihydrobiopterin | 200 | — | — | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146F/K150Q, quinonoid (6R)-L-erythro-dihydrobiopterin |
| dihydropteridine reductase (DHPR)variant Y146H | Rattus norvegicus | NADHcosubstrate q-6,7-diMePtH2 | — | 0.008 | 4.5 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146H, NADH |
| dihydropteridine reductase (DHPR)variant Y146H | Rattus norvegicus | NADHcosubstrate qBH2 | — | 0.024 | 5.8 × 10³ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146H, NADH |
| dihydropteridine reductase (DHPR)variant Y146H | Rattus norvegicus | quinonoid (6R)-L-erythro-dihydrobiopterin | 139 | 0.007 | 1.99 × 10⁴ | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146H, quinonoid (6R)-L-erythro-dihydrobiopterin |
| dihydropteridine reductase (DHPR)variant Y146H | Rattus norvegicus | quinonoid 6,7-dimethyldihydropteridine | 36 | 0.17 | 200 | pH 6.8, 25 °C | PMID 9235988 | Open record: dihydropteridine reductase (DHPR) variant Y146H, quinonoid 6,7-dimethyldihydropteridine |