CatLogenzyme kinetics catalog

EC 2.1.2.3: phosphoribosylaminoimidazolecarboxamide formyltransferase

TransferasesOpen in Browse

CatLog read 13 records for EC 2.1.2.3 from 2 papers, for 2 organisms. Names in these papers: aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activity, AICAR transformylase/IMP cyclohydrolase (PurH, EcoPurH).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 18 records for EC 2.1.2.3 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.1.2.3 in Browse.

Papers

PaperOrganismsRecords
Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolaseHomo sapiens11
Utilisation of 10-formyldihydrofolate as substrate by dihydrofolate reductase (DHFR) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) tranformylase/IMP cyclohydrolase (PurH) in…Escherichia coli2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
AICAR transformylase/IMP cyclohydrolase (PurH, EcoPurH)Escherichia coli10-formyl-5,6,7,8-tetrahydrofolate4.970.11143pH 7.5PMID 29799386Open
AICAR transformylase/IMP cyclohydrolase (PurH, EcoPurH)Escherichia coli10-formyl-7,8-dihydrofolate7.180.24528pH 7.5PMID 29799386Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide8.69 × 10⁻⁴1 × 10⁴pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant D125AHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.0140.00912pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant D125EHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.1470.005230pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant D125NHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.6030.0027200pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant K137AHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.2760.0319pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant K137RHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.5070.0027200pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant K66AHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.0620.1150.5pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant Y104AHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.1360.00350pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant Y104A/D125AHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.001——pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant Y104FHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide0.0360.003610pH 7.5PMID 14756554Open
aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), IMP cyclohydrolase (IMPCHase) activityvariant Y104F/D125AHomo sapiens5-formylaminoimidazole-4-carboxamide ribonucleotide8 × 10⁻⁴——pH 7.5PMID 14756554Open