EC 2.3.1.41: beta-ketoacyl-[acyl-carrier-protein] synthase I
TransferasesOpen in Browse
CatLog read 39 records for EC 2.3.1.41 from 3 papers, for 4 organisms. Names in these papers: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS), β-ketoacyl-ACP synthase I (ecFabB, KASI), beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), β-ketoacyl-ACP synthase I (KasA, KASI).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 14 records for EC 2.3.1.41 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.3.1.41 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering | Mus musculus | 17 |
| Substrate recognition by β-ketoacyl-ACP synthases | Escherichia coli, Mycobacterium tuberculosis | 15 |
| Recombinant expression and biochemical characterization of the unique elongating beta-ketoacyl-acyl carrier protein synthase involved in fatty acid biosynthesis of Plasmodium falciparum using… | Plasmodium falciparum | 7 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog) | Plasmodium falciparum | butanoyl-[acyl-carrier protein] (P. falciparum ACP, butyryl-PfACP) | 1.318 | 0.2111 | 6.2 | pH 7.5, 37 °C | PMID 16467310 | Open record: beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), butanoyl-[acyl-carrier protein] (P. falciparum ACP, butyryl-PfACP) |
| beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog) | Plasmodium falciparum | decanoyl-[acyl-carrier protein] (P. falciparum ACP) | 3.067 | 0.4034 | 7.7 | pH 7.5, 37 °C | PMID 16467310 | Open record: beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), decanoyl-[acyl-carrier protein] (P. falciparum ACP) |
| beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog) | Plasmodium falciparum | dodecanoyl-[acyl-carrier protein] (P. falciparum ACP) | 0.685 | 0.1964 | 3.5 | pH 7.5, 37 °C | PMID 16467310 | Open record: beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), dodecanoyl-[acyl-carrier protein] (P. falciparum ACP) |
| beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog) | Plasmodium falciparum | hexanoyl-[acyl-carrier protein] (P. falciparum ACP) | 0.96 | 0.1156 | 8.3 | pH 7.5, 37 °C | PMID 16467310 | Open record: beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), hexanoyl-[acyl-carrier protein] (P. falciparum ACP) |
| beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog) | Plasmodium falciparum | malonyl-[acyl-carrier protein] (P. falciparum ACP) | — | 0.0178 | — | pH 7.5, 37 °C | PMID 16467310 | Open record: beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), malonyl-[acyl-carrier protein] (P. falciparum ACP) |
| beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog) | Plasmodium falciparum | octanoyl-[acyl-carrier protein] (P. falciparum ACP) | 1.63 | 0.1982 | 8.2 | pH 7.5, 37 °C | PMID 16467310 | Open record: beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), octanoyl-[acyl-carrier protein] (P. falciparum ACP) |
| beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog) | Plasmodium falciparum | tetradecanoyl-[acyl-carrier protein] (P. falciparum ACP) | 1.278 | 0.437 | 3 | pH 7.5, 37 °C | PMID 16467310 | Open record: beta-ketoacyl-acyl carrier protein synthase PfFabBF (elongating condensing enzyme, FabB/FabF homolog), tetradecanoyl-[acyl-carrier protein] (P. falciparum ACP) |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetoacetyl-CoA | 7.3 | 8.6 × 10⁻⁴ | 8.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetoacetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetyl-CoAacyl-CoA varied 0.1-100 μM; holo-ACP (60 μM) | 13.7 | 0.00163 | 8.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acetyl-CoAholo-ACP (varied, extrapolated) | 99.2 | 0.012 | 8.3 × 10³ calc. | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | acyl carrier protein (holo, murine FAS ACP domain) | — | 0.245 | — | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, acyl carrier protein (holo, murine FAS ACP domain) | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | butyryl-CoA | 10.8 | 0.00164 | 6.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, butyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | crotonyl-CoA | 6 | 0.00136 | 4.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, crotonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | hydroxybutyryl-CoA | 6.1 | 0.00172 | 3.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, hydroxybutyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | malonyl-CoAacyl-CoA varied 0.1-100 μM; holo-ACP (60 μM) | 15.6 | 0.00128 | 1.22 × 10⁴ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, malonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | malonyl-CoAholo-ACP (varied, extrapolated) | 119 | 0.0088 | 1.4 × 10⁴ calc. | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, malonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | methylbutyryl-CoA | 7.2 | 0.00206 | 3.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, methylbutyryl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | methylmalonyl-CoA | 4 | 6.2 × 10⁻⁴ | 6.5 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, methylmalonyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | octanoyl-CoA | 4.1 | 7.3 × 10⁻⁴ | 5.6 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, octanoyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | palmitoyl-CoA | 2.5 | 0.0048 | 500 | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, palmitoyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | phenylacetyl-CoA | 6 | 9.6 × 10⁻⁴ | 6.2 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, phenylacetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G | Mus musculus | succinyl-CoA | 13.4 | 0.0021 | 6.4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G, succinyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G/R606A | Mus musculus | acetyl-CoA | 13 | 0.003 | 4 × 10³ | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G/R606A, acetyl-CoA | |
| malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS)variant C161G/R606A | Mus musculus | malonyl-CoA | 5 | 0.018 | 300 | PMID 29328619 | Open record: malonyl/acetyltransferase (MAT) domain of fatty acid synthase (FAS) variant C161G/R606A, malonyl-CoA | |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | lauroyl-acyl carrier protein (Escherichia coli ACP)10 μM malonyl-ecACP (footnote b); cosubstrate malonyl-ecACP | 0.057 | 0.0032 | 18 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), lauroyl-acyl carrier protein (Escherichia coli ACP) |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | lauroyl-acyl carrier protein (Escherichia coli ACP)200 μM malonyl-CoA (footnote c); cosubstrate malonyl-CoA | 0.033 | 0.0039 | 8.3 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), lauroyl-acyl carrier protein (Escherichia coli ACP) |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | lauroyl-CoA | 0.073 | 0.0586 | 1.27 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), lauroyl-CoA |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | malonyl-acyl carrier protein (Escherichia coli ACP) | 0.11 | 0.0115 | 10 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), malonyl-acyl carrier protein (Escherichia coli ACP) |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | malonyl-CoA | 0.118 | 0.153 | 0.78 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), malonyl-CoA |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | malonyl-phosphopantetheine-14-mer | 0.04 | 0.0158 | 3 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), malonyl-phosphopantetheine-14-mer |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | malonyl-phosphopantetheine-16-mer | 0.108 | 0.029 | 3.8 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), malonyl-phosphopantetheine-16-mer |
| β-ketoacyl-ACP synthase I (ecFabB, KASI) | Escherichia coli | malonyl-phosphopantetheine-8-mer | 0.018 | 0.0142 | 1.3 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI), malonyl-phosphopantetheine-8-mer |
| β-ketoacyl-ACP synthase I (ecFabB, KASI)variant K151Q | Escherichia coli | lauroyl-acyl carrier protein (Escherichia coli ACP) | 0.025 | 0.0067 | 3.7 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI) variant K151Q, lauroyl-acyl carrier protein (Escherichia coli ACP) |
| β-ketoacyl-ACP synthase I (ecFabB, KASI)variant K63Q | Escherichia coli | lauroyl-acyl carrier protein (Escherichia coli ACP) | 0.083 | 0.06 | 1.2 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI) variant K63Q, lauroyl-acyl carrier protein (Escherichia coli ACP) |
| β-ketoacyl-ACP synthase I (ecFabB, KASI)variant R62Q | Escherichia coli | lauroyl-acyl carrier protein (Escherichia coli ACP) | 0.077 | 0.05 | 1.5 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI) variant R62Q, lauroyl-acyl carrier protein (Escherichia coli ACP) |
| β-ketoacyl-ACP synthase I (ecFabB, KASI)variant R66Q | Escherichia coli | lauroyl-acyl carrier protein (Escherichia coli ACP) | 0.053 | 0.056 | 0.83 | pH 6.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (ecFabB, KASI) variant R66Q, lauroyl-acyl carrier protein (Escherichia coli ACP) |
| β-ketoacyl-ACP synthase I (KasA, KASI) | Mycobacterium tuberculosis | malonyl-phosphopantetheine-14-mer | 0.38 | 0.0086 | 48 | pH 8.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (KasA, KASI), malonyl-phosphopantetheine-14-mer |
| β-ketoacyl-ACP synthase I (KasA, KASI) | Mycobacterium tuberculosis | malonyl-phosphopantetheine-16-mer | 0.3 | 0.0051 | 60 | pH 8.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (KasA, KASI), malonyl-phosphopantetheine-16-mer |
| β-ketoacyl-ACP synthase I (KasA, KASI) | Mycobacterium tuberculosis | malonyl-phosphopantetheine-8-mer | 0.35 | 0.0047 | 75 | pH 8.5, 25 °C | PMID 22017312 | Open record: β-ketoacyl-ACP synthase I (KasA, KASI), malonyl-phosphopantetheine-8-mer |