CatLogenzyme kinetics catalog

EC 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase

TransferasesOpen in Browse

CatLog read 86 records for EC 2.5.1.10 from 6 papers, for 4 organisms. Names in these papers: geranylgeranyl pyrophosphate synthase (type-III GGPPs), geranylgeranyl diphosphate synthase (GGPPS), geranylgeranyl diphosphate synthase (GGPPs), farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsA and 3 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 30 records for EC 2.5.1.10 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.5.1.10 in Browse.

Papers

PaperOrganismsRecords
Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determinationSaccharomyces cerevisiae24
Control activity of yeast geranylgeranyl diphosphate synthase from dimer interface through H-bonds and hydrophobic interactionSaccharomyces cerevisiae22
Combined experimental and theoretical study of long-range interactions modulating dimerization and activity of yeast geranylgeranyl diphosphate synthaseSaccharomyces cerevisiae18
Temperature-dependent modulation of farnesyl diphosphate/geranylgeranyl diphosphate synthase from hyperthermophilic archaeaThermococcus kodakaraensis12
Enzymes encoded by the farnesyl diphosphate synthase gene family in the Big Sagebrush Artemisia tridentata ssp. spiciformisArtemisia tridentata ssp. spiciformis6
Functional characterization and evolution of the isotuberculosinol operon in Mycobacterium tuberculosis and related MycobacteriaMycobacterium tuberculosis4

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
farnesyl diphosphate synthase FDS-1Artemisia tridentata ssp. spiciformisdimethylallyl diphosphate6.620.0071932pH 7, 30 °CPMID 12782626Open
farnesyl diphosphate synthase FDS-1Artemisia tridentata ssp. spiciformisgeranyl diphosphate2.650.00161657pH 7, 30 °CPMID 12782626Open
farnesyl diphosphate synthase FDS-1Artemisia tridentata ssp. spiciformisisopentenyl diphosphate4.420.0055808.8pH 7, 30 °CPMID 12782626Open
farnesyl diphosphate synthase FDS-2Artemisia tridentata ssp. spiciformisdimethylallyl diphosphate1.880.006313pH 7, 30 °CPMID 12782626Open
farnesyl diphosphate synthase FDS-2Artemisia tridentata ssp. spiciformisgeranyl diphosphate3.30.0131252pH 7, 30 °CPMID 12782626Open
farnesyl diphosphate synthase FDS-2Artemisia tridentata ssp. spiciformisisopentenyl diphosphate2.20.0058378.7pH 7, 30 °CPMID 12782626Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensis(all-trans)-farnesyl diphosphate590.00173.5 × 10⁴ calc.pH 8, 70 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensis(all-trans)-farnesyl diphosphate738.1 × 10⁻⁴9.0 × 10⁴ calc.pH 8, 90 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisdimethylallyl diphosphate570.00956.0 × 10³ calc.pH 8, 70 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisdimethylallyl diphosphate750.0135.8 × 10³ calc.pH 8, 90 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisgeranyl diphosphate1040.00224.7 × 10⁴ calc.pH 8, 70 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisgeranyl diphosphate2310.0037.7 × 10⁴ calc.pH 8, 90 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisisopentenyl diphosphate50 μM DMAPP; cosubstrate 50 μM DMAPP750.0233.3 × 10³ calc.pH 8, 70 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisisopentenyl diphosphate25 μM GPP; cosubstrate 25 μM GPP1200.0225.5 × 10³ calc.pH 8, 70 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisisopentenyl diphosphate3 μM FPP; cosubstrate 3 μM FPP490.00945.2 × 10³ calc.pH 8, 70 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisisopentenyl diphosphate50 μM DMAPP; cosubstrate 50 μM DMAPP1100.0791.4 × 10³ calc.pH 8, 90 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisisopentenyl diphosphate25 μM GPP; cosubstrate 25 μM GPP2790.0319.0 × 10³ calc.pH 8, 90 °CPMID 15541397Open
farnesyl diphosphate/geranylgeranyl diphosphate synthase Tk-IdsAThermococcus kodakaraensisisopentenyl diphosphate3 μM FPP; cosubstrate 3 μM FPP770.0164.8 × 10³ calc.pH 8, 90 °CPMID 15541397Open
geranylgeranyl diphosphate synthase (GGPPs)Saccharomyces cerevisiaefarnesyl diphosphate0.0250.00327.8 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPS)Saccharomyces cerevisiaefarnesyl diphosphate0.0370.003710 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPs)Saccharomyces cerevisiaeisopentenyl diphosphate—8 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPS)Saccharomyces cerevisiaeisopentenyl diphosphate—0.0017—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPs)variant E7GSaccharomyces cerevisiaefarnesyl diphosphate0.0210.00444.8 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant E7GSaccharomyces cerevisiaeisopentenyl diphosphate—4 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant E7G/L8GSaccharomyces cerevisiaefarnesyl diphosphate1.5 × 10⁻⁴0.00280.054 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant E7G/L8GSaccharomyces cerevisiaeisopentenyl diphosphate—3 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant I9GSaccharomyces cerevisiaefarnesyl diphosphate6.2 × 10⁻⁴0.00360.17 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant I9GSaccharomyces cerevisiaeisopentenyl diphosphate—7 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant L8GSaccharomyces cerevisiaefarnesyl diphosphate0.00510.00242.1 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant L8GSaccharomyces cerevisiaeisopentenyl diphosphate—5 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant L8G/I9GSaccharomyces cerevisiaefarnesyl diphosphate7.2 × 10⁻⁵0.00310.023 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant L8G/I9GSaccharomyces cerevisiaeisopentenyl diphosphate—6 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPS)variant M111ASaccharomyces cerevisiaefarnesyl diphosphate0.040.003711 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant M111ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0025—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant M111ESaccharomyces cerevisiaefarnesyl diphosphate0.020.0092.2 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant M111ESaccharomyces cerevisiaeisopentenyl diphosphate—0.0066—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant M111FSaccharomyces cerevisiaefarnesyl diphosphate0.0360.01462.5 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant M111FSaccharomyces cerevisiaeisopentenyl diphosphate—0.0113—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N101ASaccharomyces cerevisiaefarnesyl diphosphate0.0670.006311 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N101ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0048—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N101A/N104ASaccharomyces cerevisiaefarnesyl diphosphate2 × 10⁻⁴0.01530.013 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N101A/N104ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0292—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N101A/Y105ASaccharomyces cerevisiaefarnesyl diphosphate1.3 × 10⁻⁴0.00610.021 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N101A/Y105ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0061—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N104ASaccharomyces cerevisiaefarnesyl diphosphate0.110.005520 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N104ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0055—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N104A/Y105ASaccharomyces cerevisiaefarnesyl diphosphate0.0170.04670.36 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant N104A/Y105ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0081—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant R140ASaccharomyces cerevisiaefarnesyl diphosphate0.0380.00894.3 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant R140ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0045—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant Y105ASaccharomyces cerevisiaefarnesyl diphosphate0.060.00777.8 calc.pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPS)variant Y105ASaccharomyces cerevisiaeisopentenyl diphosphate—0.0026—pH 7.5, 25 °CPMID 23534508Open
geranylgeranyl diphosphate synthase (GGPPs)variant ∆(1-6)Saccharomyces cerevisiaefarnesyl diphosphate0.0180.00434.2 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant ∆(1-6)Saccharomyces cerevisiaeisopentenyl diphosphate—6 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant ∆(1-7)Saccharomyces cerevisiaefarnesyl diphosphate0.00730.00145.2 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant ∆(1-7)Saccharomyces cerevisiaeisopentenyl diphosphate—4 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant ∆(1-8)Saccharomyces cerevisiaefarnesyl diphosphate6.6 × 10⁻⁵0.00260.025 calc.pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl diphosphate synthase (GGPPs)variant ∆(1-8)Saccharomyces cerevisiaeisopentenyl diphosphate—5 × 10⁻⁴—pH 7.5, 25 °CPMID 19245203Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)Saccharomyces cerevisiaefarnesyl pyrophosphate0.0250.00327.8 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)Saccharomyces cerevisiaegeranyl pyrophosphate0.0139 × 10⁻⁴14 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)Saccharomyces cerevisiaeisopentenyl pyrophosphateIPP varied with 20 µM FPP (saturating); cosubstrate FPP—8 × 10⁻⁴—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)Saccharomyces cerevisiaeisopentenyl pyrophosphateIPP varied with GPP as allylic substrate; cosubstrate GPP—0.0013—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant F108ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0470.002122 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant F108ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.0027—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant F108A/H139ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0160.00513.1 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant F108A/H139ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.136—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant H139ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0420.002517 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant H139ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.0051—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant L135A/H139ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0640.002724 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant L135A/H139ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.017—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant S71YSaccharomyces cerevisiaegeranyl pyrophosphate0.00340.00172.0 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant S71YSaccharomyces cerevisiaeisopentenyl pyrophosphate—0.169—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0560.001733 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.0047—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/F108ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0490.002619 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/F108ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.0033—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/F108A/H139ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0254 × 10⁻⁴62 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/F108A/H139ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.097—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/F108A/L135A/H139ASaccharomyces cerevisiaefarnesyl pyrophosphate0.00840.0018.4 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/F108A/L135A/H139ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.051—pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/H139ASaccharomyces cerevisiaefarnesyl pyrophosphate0.0390.001135 calc.pH 7.5, 25 °CPMID 16554305Open
geranylgeranyl pyrophosphate synthase (type-III GGPPs)variant Y107A/H139ASaccharomyces cerevisiaeisopentenyl pyrophosphate—0.267—pH 7.5, 25 °CPMID 16554305Open
GGPP synthase Rv0562 (grcC1)Mycobacterium tuberculosis(E)-geranyl diphosphate0.0050.00232.2 calc.pH 7, 37 °CPMID 23091471Open
GGPP synthase Rv0562 (grcC1)Mycobacterium tuberculosis(E,E)-farnesyl diphosphate0.0120.0111.1 calc.pH 7, 37 °CPMID 23091471Open
GGPP synthase Rv0562 (grcC1)Mycobacterium tuberculosisdimethylallyl diphosphate0.00280.0050.57 calc.pH 7, 37 °CPMID 23091471Open
GGPP synthase Rv0562 (grcC1)Mycobacterium tuberculosisisopentenyl diphosphate—0.0017—pH 7, 37 °CPMID 23091471Open