EC 2.7.11.11: cAMP-dependent protein kinase

TransferasesOpen in Browse

CatLog read 15 records for EC 2.7.11.11 from 3 papers, for 2 organisms. Names in these papers: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), PKACα (α-isoform of the catalytic subunit of cAMP-dependent protein kinase), protein kinase A (PKA).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 19 records for EC 2.7.11.11 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.11.11 in Browse.

Papers

Papers with records for EC 2.7.11.11
Paper	Organisms	Records
Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase	Mus musculus	12
Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome	Homo sapiens	2
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts	—	1

Records

Records for EC 2.7.11.11 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	Ala-Arg-Arg-Gln-Ala-Gly-Thr-Arg-Arg-Arg-Glu-Ser-Leu-Gly-Lys	13.4	0.0299	400	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), Ala-Arg-Arg-Gln-Ala-Gly-Thr-Arg-Arg-Arg-Glu-Ser-Leu-Gly-Lys
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	Ca_V1.3 EF-hand and PreIQ domain construct, residues 1468-1598 (site Ser1475, = Ser1535 in Ca_V1.2), with N-terminal SNA cloning artefact	1.3	—	—	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), Ca_V1.3 EF-hand and PreIQ domain construct, residues 1468-1598 (site Ser1475, = Ser1535 in Ca_V1.2), with N-terminal SNA cloning artefact
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	Gly-Ala-Gly-Arg-Glu-Arg-Asp-Arg-Arg-Arg-Gly-Ser-Thr-Pro-Trp	16.2	0.019	900	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), Gly-Ala-Gly-Arg-Glu-Arg-Asp-Arg-Arg-Arg-Gly-Ser-Thr-Pro-Trp
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	Leu-Arg-Arg-Ala-Ser-Leu-Gly	19	0.0426	470	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), Leu-Arg-Arg-Ala-Ser-Leu-Gly
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	peptide RGFARSASLGRRASFHL (human Ca_V1.2 residues 1968-1984, L1971A)	19.7	0.0097	2 × 10³	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), peptide RGFARSASLGRRASFHL (human Ca_V1.2 residues 1968-1984, L1971A)
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	peptide RGFLRSARLGRRASFHL (human Ca_V1.2 residues 1968-1984, S1975R)	7.5	0.0062	1.2 × 10³	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), peptide RGFLRSARLGRRASFHL (human Ca_V1.2 residues 1968-1984, S1975R)
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	peptide RGFLRSASLGRAASFHL (human Ca_V1.2 residues 1968-1984, R1979A)	1.1	—	—	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), peptide RGFLRSASLGRAASFHL (human Ca_V1.2 residues 1968-1984, R1979A)
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	peptide RGFLRSASLGRRASAHL (human Ca_V1.2 residues 1968-1984, F1982A)	13.1	0.0096	1.4 × 10³	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), peptide RGFLRSASLGRRASAHL (human Ca_V1.2 residues 1968-1984, F1982A)
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	peptide RGFLRSASLGRRASFHL (human Ca_V1.2 residues 1968-1984)	15.5	0.0081	1.9 × 10³	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), peptide RGFLRSASLGRRASFHL (human Ca_V1.2 residues 1968-1984)
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	peptide RTLHDIGPEIRRAISGDL (human Ca_V1.2 residues 1704-1721)	3.4	—	—	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), peptide RTLHDIGPEIRRAISGDL (human Ca_V1.2 residues 1704-1721)
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	Ser-Arg-Lys-Met-Ala-Phe-Arg-Ala-Lys-Ser-Lys-Ser-Cys-His-Asp	3.3	—	—	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), Ser-Arg-Lys-Met-Ala-Phe-Arg-Ala-Lys-Ser-Lys-Ser-Cys-His-Asp
PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα)	Mus musculus	Trp-Gly-Pro-Ala-Pro-Pro-Leu-His-Arg-Arg-Ser-Met-Pro	2	—	—	pH 7.4	PMID 39615689	Open record: PKAc (cAMP-dependent protein kinase catalytic subunit, isoform alpha; PKAcα), Trp-Gly-Pro-Ala-Pro-Pro-Leu-His-Arg-Arg-Ser-Met-Pro
PKACα (α-isoform of the catalytic subunit of cAMP-dependent protein kinase)variant L205R	Homo sapiens	adenosine 5'-triphosphate	2.15	0.0276	79.3	pH 7.4, 25 °C	PMID 29632813	Open record: PKACα (α-isoform of the catalytic subunit of cAMP-dependent protein kinase) variant L205R, adenosine 5'-triphosphate
PKACα (α-isoform of the catalytic subunit of cAMP-dependent protein kinase)variant L205R	Homo sapiens	rhodamine B-labeled methyl aminobutyric acid-Kemptide analogue (Kemptide = H2N-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH)	7.5	0.0609	123	pH 7.4, 25 °C	PMID 29632813	Open record: PKACα (α-isoform of the catalytic subunit of cAMP-dependent protein kinase) variant L205R, rhodamine B-labeled methyl aminobutyric acid-Kemptide analogue (Kemptide = H2N-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH)
protein kinase A (PKA)	—	p65 peptide LRRPS276DRELSEPMEFQ (Ser276 site)	0.7108	0.0405	5.6	25 °C	PMID 12813046	Open record: protein kinase A (PKA), p65 peptide LRRPS276DRELSEPMEFQ (Ser276 site)