Values CatLog read from this paper
A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts
PMID 12813046doi:10.1074/jbc.m211439200Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 21 records (63 values) from this paper: IkappaB kinase 2 (IKK-2, IKKbeta), IkappaB kinase i (IKK-i), casein kinase II and 4 more from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| casein kinase II | — | p65 peptide GLPNGLLS529GDEDFAAIADM (Ser529 site, S535A/S536A) | 0.0522 | 0.015 | 3.6 | 25 °C | Open record: casein kinase II, p65 peptide GLPNGLLS529GDEDFAAIADM (Ser529 site, S535A/S536A) |
| IkappaB kinase 1 (IKK-1, IKKalpha) | Homo sapiens | p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM | 0.00144 | 7.5 × 10⁻⁴ | 1.92 | 25 °C | Open record: IkappaB kinase 1 (IKK-1, IKKalpha), p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | full-length IkappaBalpha-GST fusion protein | 0.0075 | 2.3 × 10⁻⁴ | 32.8 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), full-length IkappaBalpha-GST fusion protein |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | full-length IkappaBbeta-GST fusion protein | 0.0086 | 8 × 10⁻⁴ | 10.6 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), full-length IkappaBbeta-GST fusion protein |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | full-length p65-GST fusion protein | 0.0094 | 3 × 10⁻⁴ | 31 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), full-length p65-GST fusion protein |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | IkappaBalpha peptide 1 (alpha): GLKKERLLDDRHDSGLDSMKDE | 0.011 | 6.7 × 10⁻⁴ | 17 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), IkappaBalpha peptide 1 (alpha): GLKKERLLDDRHDSGLDSMKDE |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | IkappaBbeta peptide 2 (beta): LGKAADADEWCDSGLDSLGPDA | 0.0067 | 5 × 10⁻⁴ | 13.3 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), IkappaBbeta peptide 2 (beta): LGKAADADEWCDSGLDSLGPDA |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | p65 peptide (522-540, S535A): GLPNGLLSGDEDFASIADM | 0.0106 | 3 × 10⁻⁴ | 37.8 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), p65 peptide (522-540, S535A): GLPNGLLSGDEDFASIADM |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | p65 peptide 3 (residues 522-540): GLPNGLLSGDEDFSSIADM | 0.0103 | 2 × 10⁻⁴ | 51.4 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), p65 peptide 3 (residues 522-540): GLPNGLLSGDEDFSSIADM |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | p65 peptide 4 (522-540, S529A): GLPNGLLAGDEDFSSIADM | 0.0122 | 2 × 10⁻⁴ | 56 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), p65 peptide 4 (522-540, S529A): GLPNGLLAGDEDFSSIADM |
| IkappaB kinase 2 (IKK-2, IKKbeta) | Homo sapiens | p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM | 0.0114 | 2.5 × 10⁻⁴ | 45 | 25 °C | Open record: IkappaB kinase 2 (IKK-2, IKKbeta), p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM |
| IkappaB kinase i (IKK-i) | Homo sapiens | full-length IkappaBbeta-GST fusion protein | 0.5714 | 0.009 | 61.9 | 25 °C | Open record: IkappaB kinase i (IKK-i), full-length IkappaBbeta-GST fusion protein |
| IkappaB kinase i (IKK-i) | Homo sapiens | IkappaBalpha peptide 1 (alpha): GLKKERLLDDRHDSGLDSMKDE | 0.7153 | 0.219 | 3.3 | 25 °C | Open record: IkappaB kinase i (IKK-i), IkappaBalpha peptide 1 (alpha): GLKKERLLDDRHDSGLDSMKDE |
| IkappaB kinase i (IKK-i) | Homo sapiens | IkappaBbeta peptide 2 (beta): LGKAADADEWCDSGLDSLGPDA | 0.5781 | 0.006 | 92.2 | 25 °C | Open record: IkappaB kinase i (IKK-i), IkappaBbeta peptide 2 (beta): LGKAADADEWCDSGLDSLGPDA |
| IkappaB kinase i (IKK-i) | Homo sapiens | p65 peptide (522-540, S535A): GLPNGLLSGDEDFASIADM | 0.5272 | 0.043 | 12.2 | 25 °C | Open record: IkappaB kinase i (IKK-i), p65 peptide (522-540, S535A): GLPNGLLSGDEDFASIADM |
| IkappaB kinase i (IKK-i) | Homo sapiens | p65 peptide 3 (residues 522-540): GLPNGLLSGDEDFSSIADM | 0.6058 | 0.047 | 12.8 | 25 °C | Open record: IkappaB kinase i (IKK-i), p65 peptide 3 (residues 522-540): GLPNGLLSGDEDFSSIADM |
| IkappaB kinase i (IKK-i) | Homo sapiens | p65 peptide 4 (522-540, S529A): GLPNGLLAGDEDFSSIADM | 0.6203 | 0.042 | 14.7 | 25 °C | Open record: IkappaB kinase i (IKK-i), p65 peptide 4 (522-540, S529A): GLPNGLLAGDEDFSSIADM |
| IkappaB kinase i (IKK-i) | Homo sapiens | p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM | 0.49 | 0.035 | 14 | 25 °C | Open record: IkappaB kinase i (IKK-i), p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM |
| IKK-1/IKK-2 heterodimer | Homo sapiens | p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM | 0.0153 | 3.6 × 10⁻⁴ | 42.8 | 25 °C | Open record: IKK-1/IKK-2 heterodimer, p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM |
| protein kinase A (PKA) | — | p65 peptide LRRPS276DRELSEPMEFQ (Ser276 site) | 0.7108 | 0.0405 | 5.6 | 25 °C | Open record: protein kinase A (PKA), p65 peptide LRRPS276DRELSEPMEFQ (Ser276 site) |
| TANK-binding kinase 1 (TBK-1) | Homo sapiens | p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM | 1.852 | 0.0405 | 45.8 | 25 °C | Open record: TANK-binding kinase 1 (TBK-1), p65 peptide 6 (522-540, S529A/S535A): GLPNGLLAGDEDFASIADM |