EC 2.7.11.24: mitogen-activated protein kinase

TransferasesOpen in Browse

CatLog read 20 records for EC 2.7.11.24 from 2 papers, for 1 organism. Names in these papers: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), p38α (mitogen-activated protein kinase p38α), p38α MAP kinase.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 9 records for EC 2.7.11.24 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.7.11.24 in Browse.

Papers

Papers with records for EC 2.7.11.24
Paper	Organisms	Records
Use of docking peptides to design modular substrates with high efficiency for mitogen-activated protein kinase extracellular signal-regulated kinase	—	12
Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states	Mus musculus	8

Records

Records for EC 2.7.11.24 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-FQRKTLQRRNLKGLNLNL-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	2.8	6 × 10⁻⁴	4.7 × 10³	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-FQRKTLQRRNLKGLNLNL-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-LIPALRNMVRPKLTPA-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl; randomized MEK2 docking sequence)	2.2	0.096	22	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-LIPALRNMVRPKLTPA-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl; randomized MEK2 docking sequence)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-MLARRKPVLPALTINP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	2.3	0.0056	420	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-MLARRKPVLPALTINP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-MPKKKPTPIQLNP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	2	0.0037	530	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-MPKKKPTPIQLNP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-PQKGRKPRDLELPL-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	2.3	0.0044	530	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-PQKGRKPRDLELPL-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-TGPLSPGPF-(AOO)3-FQRKTLQRRNLKGLNLNL-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	2.7	0.173	17	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-TGPLSPGPF-(AOO)3-FQRKTLQRRNLKGLNLNL-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-TGPLSPGPF-(AOO)3-MLARRKPVLPALTINP-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	3	0.338	8.3	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-TGPLSPGPF-(AOO)3-MLARRKPVLPALTINP-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-TGPLSPGPF-(AOO)3-MPKKKPTPIQLNP-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	2.8	0.344	8.3	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-TGPLSPGPF-(AOO)3-MPKKKPTPIQLNP-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
ERK1 (extracellular signal-regulated kinase 1, MAP kinase)	—	fluorescein-TGPLSPGPF-NH2 (N-terminal fluorescein, C-terminal amide; no docking peptide)	4.2	0.127	32	pH 7.2, 30 °C	PMID 17918909	Open record: ERK1 (extracellular signal-regulated kinase 1, MAP kinase), fluorescein-TGPLSPGPF-NH2 (N-terminal fluorescein, C-terminal amide; no docking peptide)
p38α (mitogen-activated protein kinase p38α)variant p38α/pT (monophosphorylated on Thr-180)	Mus musculus	adenosine 5'-triphosphate	0.062	1.669	0.0371	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pT (monophosphorylated on Thr-180), adenosine 5'-triphosphate
p38α (mitogen-activated protein kinase p38α)variant p38α/pT (monophosphorylated on Thr-180)	Mus musculus	ATF2-(1-109) (activating transcription factor 2 residues 1-109)	3.8	0.0201	190	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pT (monophosphorylated on Thr-180), ATF2-(1-109) (activating transcription factor 2 residues 1-109)
p38α (mitogen-activated protein kinase p38α)variant p38α/pT (monophosphorylated on Thr-180)	Mus musculus	KRELVEPLTPSGEAPNQALLR (EGF receptor peptide, residues 661-681)	6.99	2.8	2.5	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pT (monophosphorylated on Thr-180), KRELVEPLTPSGEAPNQALLR (EGF receptor peptide, residues 661-681)
p38α (mitogen-activated protein kinase p38α)variant p38α/pTpY (bisphosphorylated on Thr-180 and Tyr-182)	Mus musculus	adenosine 5'-triphosphate	0.562	0.212	2.65	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pTpY (bisphosphorylated on Thr-180 and Tyr-182), adenosine 5'-triphosphate
p38α (mitogen-activated protein kinase p38α)variant p38α/pTpY (bisphosphorylated on Thr-180 and Tyr-182)	Mus musculus	ATF2-(1-109) (activating transcription factor 2 residues 1-109)	4.7	0.00203	2.3 × 10³	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pTpY (bisphosphorylated on Thr-180 and Tyr-182), ATF2-(1-109) (activating transcription factor 2 residues 1-109)
p38α (mitogen-activated protein kinase p38α)variant p38α/pTpY (bisphosphorylated on Thr-180 and Tyr-182)	Mus musculus	KRELVEPLTPSGEAPNQALLR (EGF receptor peptide, residues 661-681)	31.6	0.656	48	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pTpY (bisphosphorylated on Thr-180 and Tyr-182), KRELVEPLTPSGEAPNQALLR (EGF receptor peptide, residues 661-681)
p38α (mitogen-activated protein kinase p38α)variant p38α/pY (monophosphorylated on Tyr-182)	Mus musculus	ATF2-(1-109) (activating transcription factor 2 residues 1-109)	—	—	2.497	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pY (monophosphorylated on Tyr-182), ATF2-(1-109) (activating transcription factor 2 residues 1-109)
p38α (mitogen-activated protein kinase p38α)variant p38α/pY (monophosphorylated on Tyr-182)	Mus musculus	KRELVEPLTPSGEAPNQALLR (EGF receptor peptide, residues 661-681)	—	—	0.0224	pH 7, 25 °C	PMID 18669639	Open record: p38α (mitogen-activated protein kinase p38α) variant p38α/pY (monophosphorylated on Tyr-182), KRELVEPLTPSGEAPNQALLR (EGF receptor peptide, residues 661-681)
p38α MAP kinase	—	fluorescein-MLARRKPVLPALTINP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	16.7	0.03	550	pH 7.2, 30 °C	PMID 17918909	Open record: p38α MAP kinase, fluorescein-MLARRKPVLPALTINP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
p38α MAP kinase	—	fluorescein-MPKKKPTPIQLNP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)	9.5	0.065	145	pH 7.2, 30 °C	PMID 17918909	Open record: p38α MAP kinase, fluorescein-MPKKKPTPIQLNP-(AOO)3-TGPLSPGPF-NH2 (AOO = 8-amino-3,6-dioxaoctanoyl)
p38α MAP kinase	—	fluorescein-TGPLSPGPF-NH2 (N-terminal fluorescein, C-terminal amide; no docking peptide)	9.5	1.2	8.3	pH 7.2, 30 °C	PMID 17918909	Open record: p38α MAP kinase, fluorescein-TGPLSPGPF-NH2 (N-terminal fluorescein, C-terminal amide; no docking peptide)