CatLogenzyme kinetics catalog

EC 3.4.21.21: coagulation factor VIIa

HydrolasesOpen in Browse

CatLog read 24 records for EC 3.4.21.21 from 2 papers, for 1 organism. Names in these papers: coagulation Factor VIIa (FVIIa), factor VIIa.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 41 records for EC 3.4.21.21 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.21.21 in Browse.

Papers

PaperOrganismsRecords
Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancementHomo sapiens12
Activation loop 3 and the 170 loop interact in the active conformation of coagulation factor VIIaHomo sapiens12

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
coagulation Factor VIIa (FVIIa)Homo sapiensD-Ile-Pro-Arg-p-nitroanilidefree enzyme; no tissue factor—10.4—pH 7.4PMID 14686879Open
coagulation Factor VIIa (FVIIa)Homo sapiensD-Ile-Pro-Arg-p-nitroanilide—1.6—pH 7.4PMID 14686879Open
coagulation Factor VIIa (FVIIa)Homo sapiensFactor Xfree enzyme; no tissue factor1.5 × 10⁻⁴0.00440.034pH 7.4, 22 °CPMID 14686879Open
coagulation Factor VIIa (FVIIa)Homo sapiensFactor X0.00770.0032.6pH 7.4, 22 °CPMID 14686879Open
coagulation Factor VIIa (FVIIa)variant L305V/S314E/K337A/F374YHomo sapiensD-Ile-Pro-Arg-p-nitroanilidefree enzyme; no tissue factor—1.9—pH 7.4PMID 14686879Open
coagulation Factor VIIa (FVIIa)variant L305V/S314E/K337A/F374YHomo sapiensD-Ile-Pro-Arg-p-nitroanilide—0.85—pH 7.4PMID 14686879Open
coagulation Factor VIIa (FVIIa)variant L305V/S314E/K337A/F374YHomo sapiensFactor Xfree enzyme; no tissue factor0.00120.00270.44pH 7.4, 22 °CPMID 14686879Open
coagulation Factor VIIa (FVIIa)variant L305V/S314E/K337A/F374YHomo sapiensFactor X0.0070.00213.3pH 7.4, 22 °CPMID 14686879Open
coagulation Factor VIIa (FVIIa)variant V158D/E296V/M298QHomo sapiensD-Ile-Pro-Arg-p-nitroanilidefree enzyme; no tissue factor—6.7—pH 7.4PMID 14686879Open
coagulation Factor VIIa (FVIIa)variant V158D/E296V/M298QHomo sapiensD-Ile-Pro-Arg-p-nitroanilide—1.7—pH 7.4PMID 14686879Open
coagulation Factor VIIa (FVIIa)variant V158D/E296V/M298QHomo sapiensFactor Xfree enzyme; no tissue factor0.00530.00182.9pH 7.4, 22 °CPMID 14686879Open
coagulation Factor VIIa (FVIIa)variant V158D/E296V/M298QHomo sapiensFactor X0.0240.002111.4pH 7.4, 22 °CPMID 14686879Open
factor VIIaHomo sapiensD-Ile-Pro-Arg-p-nitroanilidefree FVIIa; no tissue factor—10—pH 7.4PMID 19490111Open
factor VIIaHomo sapiensD-Ile-Pro-Arg-p-nitroanilidewith 150 nM soluble tissue factor (sTF, residues 1-219)—1.8—pH 7.4PMID 19490111Open
factor VIIaHomo sapiensfactor Xfree FVIIa; no tissue factor4.9 × 10⁻⁵0.0030.016pH 7.4PMID 19490111Open
factor VIIaHomo sapiensfactor Xwith 150 nM soluble tissue factor (sTF, residues 1-219)0.00270.00191.4pH 7.4PMID 19490111Open
factor VIIaHomo sapiensfactor Xwith 1 pM lipidated tissue factor0.0041.5 × 10⁻⁵270pH 7.4PMID 19490111Open
factor VIIaHomo sapienspyroGlu-Pro-Arg-p-nitroanilide—1.9—pH 7.4PMID 19490111Open
factor VIIavariant G372AHomo sapiensD-Ile-Pro-Arg-p-nitroanilidefree FVIIa; no tissue factor—14—pH 7.4PMID 19490111Open
factor VIIavariant G372AHomo sapiensD-Ile-Pro-Arg-p-nitroanilidewith 150 nM soluble tissue factor (sTF, residues 1-219)—7.1—pH 7.4PMID 19490111Open
factor VIIavariant G372AHomo sapiensfactor Xfree FVIIa; no tissue factor7 × 10⁻⁶0.00540.0013pH 7.4PMID 19490111Open
factor VIIavariant G372AHomo sapiensfactor Xwith 150 nM soluble tissue factor (sTF, residues 1-219)6.2 × 10⁻⁴0.00320.19pH 7.4PMID 19490111Open
factor VIIavariant G372AHomo sapiensfactor Xwith 1 pM lipidated tissue factor0.00211.2 × 10⁻⁵180pH 7.4PMID 19490111Open
factor VIIavariant G372AHomo sapienspyroGlu-Pro-Arg-p-nitroanilide—3.9—pH 7.4PMID 19490111Open