EC 3.4.22.36: caspase-1
HydrolasesOpen in Browse
CatLog read 22 records for EC 3.4.22.36 from 3 papers, for 2 organisms. Names in these papers: caspase-1, dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 2 records for EC 3.4.22.36 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.22.36 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold | Canis lupus familiaris | 11 |
| Substrate specificities of caspase family proteases | — | 8 |
| Differentiating the Substrate Profiles of Inflammatory Caspases Using Extended Förster Resonance Energy Transfer-Based Peptide Substrates | Homo sapiens | 3 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| caspase-1variant D381E | — | acetyl-Asp-Gln-Met-Asp p-nitroanilide | 0.94 | 0.045 | 21 | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Asp-Gln-Met-Asp p-nitroanilide |
| caspase-1variant D381E | — | acetyl-Asp-Glu-Val-Asp p-nitroanilide | 0.5 | 0.018 | 30 | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Asp-Glu-Val-Asp p-nitroanilide |
| caspase-1variant D381E | — | acetyl-Leu-Glu-Val-Asp p-nitroanilide | 0.4 | 0.0085 | 54 | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Leu-Glu-Val-Asp p-nitroanilide |
| caspase-1variant D381E | — | acetyl-Tyr-Glu-Val-Asp p-nitroanilide | 0.57 | 0.0073 | 79 | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Tyr-Glu-Val-Asp p-nitroanilide |
| caspase-1variant D381E | — | acetyl-Tyr-Glu-Val-Asp-Gly-Trp amide | — | 0.105 | — | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Tyr-Glu-Val-Asp-Gly-Trp amide |
| caspase-1variant D381E | — | acetyl-Tyr-Val-Ala-Asp p-nitroanilide | 1.5 | 0.023 | 63 | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Tyr-Val-Ala-Asp p-nitroanilide |
| caspase-1variant D381E | — | acetyl-Val-Gln-Val-Asp p-nitroanilide | 0.33 | 0.12 | 2.8 | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Val-Gln-Val-Asp p-nitroanilide |
| caspase-1variant D381E | — | acetyl-Val-Glu-Ile-Asp p-nitroanilide | 0.56 | 0.046 | 12 | pH 7.5 | PMID 9092497 | Open record: caspase-1 variant D381E, acetyl-Val-Glu-Ile-Asp p-nitroanilide |
| caspase-1 | Homo sapiens | A(MCA)-Glu-His-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine) | — | 0.051 | — | pH 7.4, 25 °C | PMID 41321079 | Open record: caspase-1, A(MCA)-Glu-His-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine) |
| caspase-1 | Homo sapiens | A(MCA)-Val-Ala-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine) | — | 0.16 | — | pH 7.4, 25 °C | PMID 41321079 | Open record: caspase-1, A(MCA)-Val-Ala-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine) |
| caspase-1 | Homo sapiens | A(MCA)-Val-Ala-Asp-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine) | — | 0.16 | — | pH 7.4, 25 °C | PMID 41321079 | Open record: caspase-1, A(MCA)-Val-Ala-Asp-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine) |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | LLSDGID | 4.93 | 0.022 | 222.6 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, LLSDGID |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | LSDGIDE | 0.3 | 0.115 | 2.6 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, LSDGIDE |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin | 1.22 | 0.021 | 57 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin | 2.96 | 0.016 | 180 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin | 8.87 | 0.038 | 233 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SDGIDEE | 0.02 | 0.038 | 0.77 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SDGIDEE |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDG | 1.06 | 0.087 | 12 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDG |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGI | 3.75 | 0.052 | 74.4 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGI |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGID | 2.23 | 0.049 | 44.5 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGID |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGIDE | 3 | 0.038 | 79.6 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGIDE |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGIDEE | 2.72 | 0.047 | 58.4 | pH 7.2, 37 °C | PMID 35427646 | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGIDEE |