Values CatLog read from this paper
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
PMID 35427646doi:10.1016/j.jbc.2022.101931Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 14 records (42 values) from this paper: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain from Canis lupus familiaris.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | LLSDGID | 4.93 | 0.022 | 222.6 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, LLSDGID |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | LSDGIDE | 0.3 | 0.115 | 2.6 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, LSDGIDE |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin | 1.22 | 0.021 | 57 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin | 2.96 | 0.016 | 180 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin | 8.87 | 0.038 | 233 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SDGIDEE | 0.02 | 0.038 | 0.77 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SDGIDEE |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDG | 1.06 | 0.087 | 12 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDG |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGI | 3.75 | 0.052 | 74.4 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGI |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGID | 2.23 | 0.049 | 44.5 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGID |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGIDE | 3 | 0.038 | 79.6 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGIDE |
| dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain | Canis lupus familiaris | SLLSDGIDEE | 2.72 | 0.047 | 58.4 | pH 7.2, 37 °C | Open record: dog inflammatory caspase (hybrid caspase-1/caspase-4), catalytic domain, SLLSDGIDEE |
| resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domainvariant ancestral reconstructed sequence (node 22) | — | N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin | 0.58 | 0.0192 | 30 | pH 7.2, 37 °C | Open record: resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain variant ancestral reconstructed sequence (node 22), N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin |
| resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domainvariant ancestral reconstructed sequence (node 22) | — | N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin | 1.53 | 0.073 | 21.7 | pH 7.2, 37 °C | Open record: resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain variant ancestral reconstructed sequence (node 22), N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin |
| resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domainvariant ancestral reconstructed sequence (node 22) | — | N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin | 9.2 | 0.017 | 533 | pH 7.2, 37 °C | Open record: resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain variant ancestral reconstructed sequence (node 22), N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin |