EC 3.4.22.57: caspase-4

HydrolasesOpen in Browse

CatLog read 13 records for EC 3.4.22.57 from 3 papers, for 1 organism. Names in these papers: caspase-4, resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 3 records for EC 3.4.22.57 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.4.22.57 in Browse.

Papers

Papers with records for EC 3.4.22.57
Paper	Organisms	Records
Substrate specificities of caspase family proteases	—	8
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold	—	3
Differentiating the Substrate Profiles of Inflammatory Caspases Using Extended Förster Resonance Energy Transfer-Based Peptide Substrates	Homo sapiens	2

Records

Records for EC 3.4.22.57 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
caspase-4	—	acetyl-Asp-Gln-Met-Asp p-nitroanilide	0.09	0.35	0.27	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Asp-Gln-Met-Asp p-nitroanilide
caspase-4	—	acetyl-Asp-Glu-Val-Asp p-nitroanilide	0.05	0.032	1.8	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Asp-Glu-Val-Asp p-nitroanilide
caspase-4	—	acetyl-Leu-Glu-Val-Asp p-nitroanilide	0.14	0.044	3.2	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Leu-Glu-Val-Asp p-nitroanilide
caspase-4	—	acetyl-Leu-Glu-Val-Asp-Gly-Trp amide	—	0.43	—	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Leu-Glu-Val-Asp-Gly-Trp amide
caspase-4	—	acetyl-Tyr-Glu-Val-Asp p-nitroanilide	0.08	0.031	2.6	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Tyr-Glu-Val-Asp p-nitroanilide
caspase-4	—	acetyl-Tyr-Val-Ala-Asp p-nitroanilide	0.24	0.874	0.28	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Tyr-Val-Ala-Asp p-nitroanilide
caspase-4	—	acetyl-Val-Gln-Val-Asp p-nitroanilide	0.12	0.72	0.17	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Val-Gln-Val-Asp p-nitroanilide
caspase-4	—	acetyl-Val-Glu-Ile-Asp p-nitroanilide	0.15	0.205	0.75	pH 7.5	PMID 9092497	Open record: caspase-4, acetyl-Val-Glu-Ile-Asp p-nitroanilide
caspase-4	Homo sapiens	A(MCA)-Gln-Pro-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine)	—	0.15	—	pH 7.4, 25 °C	PMID 41321079	Open record: caspase-4, A(MCA)-Gln-Pro-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine)
caspase-4	Homo sapiens	A(MCA)-Glu-His-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine)	—	0.06	—	pH 7.4, 25 °C	PMID 41321079	Open record: caspase-4, A(MCA)-Glu-His-Asp-Gly-Lys(dabsyl)-NH2 (A(MCA) = beta-(7-methoxycoumarin-4-yl)-alanine)
resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domainvariant ancestral reconstructed sequence (node 22)	—	N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin	0.58	0.0192	30	pH 7.2, 37 °C	PMID 35427646	Open record: resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain variant ancestral reconstructed sequence (node 22), N-acetyl-Phe-Glu-Ala-Asp-7-amino-4-carbamoylmethylcoumarin
resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domainvariant ancestral reconstructed sequence (node 22)	—	N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin	1.53	0.073	21.7	pH 7.2, 37 °C	PMID 35427646	Open record: resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain variant ancestral reconstructed sequence (node 22), N-acetyl-Trp-Gln-Pro-Asp-7-amino-4-carbamoylmethylcoumarin
resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domainvariant ancestral reconstructed sequence (node 22)	—	N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin	9.2	0.017	533	pH 7.2, 37 °C	PMID 35427646	Open record: resurrected ancestral Carnivora inflammatory caspase (caspase node 22), catalytic domain variant ancestral reconstructed sequence (node 22), N-acetyl-Trp-Glu-His-Asp-7-amino-4-trifluoromethylcoumarin