EC 3.6.1.52: diphosphoinositol-polyphosphate diphosphatase

HydrolasesOpen in Browse

CatLog read 55 records for EC 3.6.1.52 from 6 papers, for 3 organisms. Names in these papers: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), Siw14, DIPP (diphosphoinositol polyphosphate phosphohydrolase), hAps1 and 7 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 15 records for EC 3.6.1.52 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.6.1.52 in Browse.

Papers

Papers with records for EC 3.6.1.52
Paper	Organisms	Records
New structural insights reveal an expanded reaction cycle for inositol pyrophosphate hydrolysis by human DIPP1	Homo sapiens	21
Structural and biochemical characterization of Siw14: A protein-tyrosine phosphatase fold that metabolizes inositol pyrophosphates	Saccharomyces cerevisiae	13
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases	Homo sapiens	9
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase	Homo sapiens	6
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping…	Homo sapiens, Saccharomyces cerevisiae and 1 more	5
Optimization of a high throughput screening platform to identify inhibitors of asymmetric diadenosine polyphosphatases	Homo sapiens	1

Records

Records for EC 3.6.1.52 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
Aps1 (Ap6A hydrolase)	Schizosaccharomyces pombe	diphosphoinositol pentakisphosphate	0.17	3.1 × 10⁻⁵	5.3 × 10³	pH 7.2	PMID 10419486	Open record: Aps1 (Ap6A hydrolase), diphosphoinositol pentakisphosphate
DIPP (diphosphoinositol polyphosphate phosphohydrolase)	Homo sapiens	diadenosine 5',5'''-P1,P5-pentaphosphate	0.42	0.0077	55	pH 7.6, 37 °C	PMID 10419486	Open record: DIPP (diphosphoinositol polyphosphate phosphohydrolase), diadenosine 5',5'''-P1,P5-pentaphosphate
DIPP (diphosphoinositol polyphosphate phosphohydrolase)	Homo sapiens	diadenosine 5',5'''-P1,P6-hexaphosphate	0.5	0.0059	85	pH 7.6, 37 °C	PMID 10419486	Open record: DIPP (diphosphoinositol polyphosphate phosphohydrolase), diadenosine 5',5'''-P1,P6-hexaphosphate
DIPP (diphosphoinositol polyphosphate phosphohydrolase)	Homo sapiens	diphosphoinositol pentakisphosphate	0.2	4.2 × 10⁻⁶	4.74 × 10⁴	pH 7.2	PMID 10419486	Open record: DIPP (diphosphoinositol polyphosphate phosphohydrolase), diphosphoinositol pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)	Homo sapiens	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate	0.237	—	1.5 × 10³	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)	Homo sapiens	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate	0.165	—	1.79 × 10³	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)	Homo sapiens	2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate	0.042	—	460	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), 2-diphospho-myo-inositol 1,3,4,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)	Homo sapiens	4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate	0.029	—	210	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), 4-diphospho-1D-myo-inositol 1,2,3,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)	Homo sapiens	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate	0.081	—	650	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)	Homo sapiens	5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate	0.095	—	380	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1), 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A	Homo sapiens	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate	—	—	520	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant H42A, 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A	Homo sapiens	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate	—	—	680	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant H42A, 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A	Homo sapiens	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate	—	—	150	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant H42A, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A/R45A	Homo sapiens	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate	—	—	110	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant H42A/R45A, 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A/R45A	Homo sapiens	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate	—	—	200	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant H42A/R45A, 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant H42A/R45A	Homo sapiens	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate	—	—	80	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant H42A/R45A, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant K18A	Homo sapiens	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate	—	—	50	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant K18A, 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant K18A	Homo sapiens	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate	—	—	70	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant K18A, 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant K18A	Homo sapiens	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate	—	—	40	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant K18A, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R41A	Homo sapiens	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate	—	—	590	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant R41A, 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R41A	Homo sapiens	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate	—	—	690	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant R41A, 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R41A	Homo sapiens	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate	—	—	230	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant R41A, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R45A	Homo sapiens	1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate	—	—	540	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant R45A, 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R45A	Homo sapiens	1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate	—	—	860	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant R45A, 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate
DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1)variant R45A	Homo sapiens	5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate	—	—	300	pH 7.2	PMID 33475202	Open record: DIPP1 (diphosphoinositol polyphosphate phosphohydrolase 1) variant R45A, 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
hAps1	Homo sapiens	diadenosine 5',5'''-hexaphosphate	0.17	0.013	13.1	pH 7.6, 37 °C	PMID 12121577	Open record: hAps1, diadenosine 5',5'''-hexaphosphate
hAps1	Homo sapiens	diadenosine 5',5'''-pentaphosphate	0.4	0.037	10.8	pH 7.6, 37 °C	PMID 12121577	Open record: hAps1, diadenosine 5',5'''-pentaphosphate
hAps1	Homo sapiens	diphosphoinositol pentakisphosphate	0.2	0.004	50	pH 7.6	PMID 12121577	Open record: hAps1, diphosphoinositol pentakisphosphate
hAps1-39N	Homo sapiens	diadenosine 5',5'''-hexaphosphate	0.16	0.011	14.5	pH 7.6, 37 °C	PMID 12121577	Open record: hAps1-39N, diadenosine 5',5'''-hexaphosphate
hAps1-39N	Homo sapiens	diadenosine 5',5'''-pentaphosphate	0.4	0.05	8	pH 7.6, 37 °C	PMID 12121577	Open record: hAps1-39N, diadenosine 5',5'''-pentaphosphate
hAps1-39N	Homo sapiens	diphosphoinositol pentakisphosphate	0.09	3 × 10⁻⁴	290	pH 7.6	PMID 12121577	Open record: hAps1-39N, diphosphoinositol pentakisphosphate
hAps2	Homo sapiens	diadenosine 5',5'''-hexaphosphate	0.2	0.019	10.5	pH 7.6, 37 °C	PMID 12121577	Open record: hAps2, diadenosine 5',5'''-hexaphosphate
hAps2	Homo sapiens	diadenosine 5',5'''-pentaphosphate	0.8	0.05	16	pH 7.6, 37 °C	PMID 12121577	Open record: hAps2, diadenosine 5',5'''-pentaphosphate
hAps2	Homo sapiens	diphosphoinositol pentakisphosphate	0.14	0.0013	110	pH 7.6	PMID 12121577	Open record: hAps2, diphosphoinositol pentakisphosphate
hDIPP3α	Homo sapiens	bis-diphosphoinositol tetrakisphosphate	—	—	180	pH 7.2, 37 °C	PMID 12105228	Open record: hDIPP3α, bis-diphosphoinositol tetrakisphosphate
hDIPP3α	Homo sapiens	diadenosine 5',5'''-P1,P6-hexaphosphate	0.58	0.033	18	pH 7.6, 37 °C	PMID 12105228	Open record: hDIPP3α, diadenosine 5',5'''-P1,P6-hexaphosphate
hDIPP3α	Homo sapiens	diphosphoinositol pentakisphosphate	0.16	8.8 × 10⁻⁵	1.8 × 10³	pH 7.2, 37 °C	PMID 12105228	Open record: hDIPP3α, diphosphoinositol pentakisphosphate
hDIPP3β	Homo sapiens	bis-diphosphoinositol tetrakisphosphate	—	—	490	pH 7.2, 37 °C	PMID 12105228	Open record: hDIPP3β, bis-diphosphoinositol tetrakisphosphate
hDIPP3β	Homo sapiens	diadenosine 5',5'''-P1,P6-hexaphosphate	0.95	0.043	22	pH 7.6, 37 °C	PMID 12105228	Open record: hDIPP3β, diadenosine 5',5'''-P1,P6-hexaphosphate
hDIPP3β	Homo sapiens	diphosphoinositol pentakisphosphate	0.22	5.3 × 10⁻⁵	4.2 × 10³	pH 7.2, 37 °C	PMID 12105228	Open record: hDIPP3β, diphosphoinositol pentakisphosphate
Nudt3 (DIPP)	Homo sapiens	P1,P5-di(adenosine-5') pentaphosphate	4 × 10⁻⁴	0.024	0.016	pH 8, 23 °C	PMID 39521360	Open record: Nudt3 (DIPP), P1,P5-di(adenosine-5') pentaphosphate
Siw14	Saccharomyces cerevisiae	1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate	0.63	0.0101	62	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14, 1,5-bisdiphosphoinositol 2,3,4,6-tetrakisphosphate
Siw14	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	1.31	0.0104	125	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphateresidues 116-281 (N-terminally truncated catalytic core)	1.32	0.0116	114	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14	Saccharomyces cerevisiae	5-diphosphoinositol 1,3,4,6-tetrakisphosphate	0.77	0.0568	14	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14, 5-diphosphoinositol 1,3,4,6-tetrakisphosphate
Siw14variant E185A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.8	0.0122	66	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant E185A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant H219A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.38	0.017	22	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant H219A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant K184A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.46	0.0471	10	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant K184A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant K218A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.48	0.0286	17	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant K218A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant K250A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.21	0.0326	6	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant K250A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant N183A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.57	0.0102	56	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant N183A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant N215A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.29	0.007	41	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant N215A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant R216A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	1.26	0.0145	87	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant R216A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
Siw14variant R252A	Saccharomyces cerevisiae	5-diphosphoinositol 1,2,3,4,6-pentakisphosphate	0.35	0.0481	7	pH 7.2, 30 °C	PMID 29540476	Open record: Siw14 variant R252A, 5-diphosphoinositol 1,2,3,4,6-pentakisphosphate
YOR163w (Ap6A hydrolase)	Saccharomyces cerevisiae	diphosphoinositol pentakisphosphate	0.06	3.1 × 10⁻⁵	2 × 10³	pH 7.2	PMID 10419486	Open record: YOR163w (Ap6A hydrolase), diphosphoinositol pentakisphosphate