CatLogenzyme kinetics catalog

EC 5.4.99.2: methylmalonyl-CoA mutase

IsomerasesOpen in Browse

CatLog read 24 records for EC 5.4.99.2 from 3 papers, for 1 organism. Names in these papers: methylmalonyl-CoA mutase (MUT), methylmalonyl-CoA mutase (MCM), methylmalonyl CoA mutase.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 41 records for EC 5.4.99.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 5.4.99.2 in Browse.

Papers

PaperOrganismsRecords
Functional characterization and categorization of missense mutations that cause methylmalonyl-CoA mutase (MUT) deficiencyHomo sapiens18
Mutagenesis of a conserved glutamate reveals the contribution of electrostatic energy to adenosylcobalamin co-C bond homolysis in ornithine 4,5-aminomutase and methylmalonyl-CoA mutaseHomo sapiens4
Purification and properties of methylmalonyl coenzyme A mutase from human liverHomo sapiens2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
methylmalonyl CoA mutaseHomo sapiensDL-methylmalonyl coenzyme A—3—pH 7.4, 37 °CPMID 6124211Open
methylmalonyl CoA mutaseHomo sapiensL-methylmalonyl coenzyme A—1.5—pH 7.4, 37 °CPMID 6124211Open
methylmalonyl-CoA mutase (MCM)Homo sapiens(R,S)-methylmalonyl-CoA3.95——pH 7.5, 30 °CPMID 23311430Open
methylmalonyl-CoA mutase (MCM)variant E392AHomo sapiens(R,S)-methylmalonyl-CoA0.32——pH 7.5, 30 °CPMID 23311430Open
methylmalonyl-CoA mutase (MCM)variant E392DHomo sapiens(R,S)-methylmalonyl-CoA0.012——pH 7.5, 30 °CPMID 23311430Open
methylmalonyl-CoA mutase (MCM)variant E392QHomo sapiens(R,S)-methylmalonyl-CoA0.25——pH 7.5, 30 °CPMID 23311430Open
methylmalonyl-CoA mutase (MUT)Homo sapiensadenosylcobalamin0.1 M potassium phosphate buffer pH 7.4; 30 min at 37 °C—4.7 × 10⁻⁶—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)Homo sapiensadenosylcobalamin0.1 M potassium phosphate buffer; 50-100 µg cell protein—4.74 × 10⁻⁶—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant F573SHomo sapiensadenosylcobalamin—2.14 × 10⁻⁵—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant G426RHomo sapiensadenosylcobalamin—0.009261—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant G648DHomo sapiensadenosylcobalamin—0.006612—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant G717VHomo sapiensadenosylcobalamin—0.008484—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant L736FHomo sapiensadenosylcobalamin—2.21 × 10⁻⁴—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant M700KHomo sapiensadenosylcobalamin—3.76 × 10⁻⁴—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant N366SHomo sapiensadenosylcobalamin—2.19 × 10⁻⁴—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant P86LHomo sapiensadenosylcobalamin—0.003014—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant R694LHomo sapiensadenosylcobalamin—8.41 × 10⁻⁵—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant R694WHomo sapiensadenosylcobalamin—4.59 × 10⁻⁵—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant S344FHomo sapiensadenosylcobalamin—3.64 × 10⁻⁵—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant T387IHomo sapiensadenosylcobalamin—6.66 × 10⁻⁵—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant V633GHomo sapiensadenosylcobalamin—0.001016—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant Y100CHomo sapiensadenosylcobalamin—0.003648—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant Y231NHomo sapiensadenosylcobalamin—0.00602—pH 7.4, 37 °CPMID 25125334Open
methylmalonyl-CoA mutase (MUT)variant Y316CHomo sapiensadenosylcobalamin—1.98 × 10⁻⁵—pH 7.4, 37 °CPMID 25125334Open