EC 6.1.1.20: phenylalanine-tRNA ligase
LigasesOpen in Browse
CatLog read 17 records for EC 6.1.1.20 from 2 papers, for 2 organisms. Names in these papers: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS), HsctPheRS (human cytoplasmic phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer), HsmtPheRS (human mitochondrial phenylalanyl-tRNA synthetase, monomer), TtPheRS (phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 115 records for EC 6.1.1.20 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 6.1.1.20 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2 | Homo sapiens | 9 |
| Bacterial and eukaryotic phenylalanyl-tRNA synthetases catalyze misaminoacylation of tRNA(Phe) with 3,4-dihydroxy-L-phenylalanine | Homo sapiens, Thermus thermophilus | 8 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| HsctPheRS (human cytoplasmic phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer) | Homo sapiens | 3,4-dihydroxy-L-phenylalanine | 0.23 | 0.65 | 0.37 | pH 8, 30 °C | PMID 22035791 | Open record: HsctPheRS (human cytoplasmic phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer), 3,4-dihydroxy-L-phenylalanine |
| HsctPheRS (human cytoplasmic phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer) | Homo sapiens | DL-m-tyrosine | 0.65 | 0.13 | 5 | pH 8, 30 °C | PMID 22035791 | Open record: HsctPheRS (human cytoplasmic phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer), DL-m-tyrosine |
| HsctPheRS (human cytoplasmic phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer) | Homo sapiens | L-phenylalanine | 0.87 | 0.0032 | 270 | pH 8, 30 °C | PMID 22035791 | Open record: HsctPheRS (human cytoplasmic phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer), L-phenylalanine |
| HsmtPheRS (human mitochondrial phenylalanyl-tRNA synthetase, monomer) | Homo sapiens | 3,4-dihydroxy-L-phenylalanine1.3-4 μM E. coli; E. coli | 0.027 | 0.52 | 0.052 | pH 8.5, 37 °C | PMID 22035791 | Open record: HsmtPheRS (human mitochondrial phenylalanyl-tRNA synthetase, monomer), 3,4-dihydroxy-L-phenylalanine |
| HsmtPheRS (human mitochondrial phenylalanyl-tRNA synthetase, monomer) | Homo sapiens | 3,4-dihydroxy-L-phenylalanine2-3 μM human cytoplasmic; human cytoplasmic | 0.057 | 0.6 | 0.095 | pH 8.5, 37 °C | PMID 22035791 | Open record: HsmtPheRS (human mitochondrial phenylalanyl-tRNA synthetase, monomer), 3,4-dihydroxy-L-phenylalanine |
| HsmtPheRS (human mitochondrial phenylalanyl-tRNA synthetase, monomer) | Homo sapiens | L-phenylalanine | 0.075 | 0.0026 | 28 | pH 8.5, 37 °C | PMID 22035791 | Open record: HsmtPheRS (human mitochondrial phenylalanyl-tRNA synthetase, monomer), L-phenylalanine |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) | Homo sapiens | L-phenylalanine | 0.192 | 0.0024 | 80 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS), L-phenylalanine |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) | Homo sapiens | tRNA^{Phe} | 0.192 | 0.0012 | 160 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS), tRNA^{Phe} |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS)variant D289Y | Homo sapiens | tRNA^{Phe} | 0.083 | 0.001 | 83 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) variant D289Y, tRNA^{Phe} |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS)variant H99D | Homo sapiens | L-phenylalanine | 0.012 | 0.0056 | 2.2 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) variant H99D, L-phenylalanine |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS)variant P49A | Homo sapiens | tRNA^{Phe} | 0.138 | 0.0011 | 125 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) variant P49A, tRNA^{Phe} |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS)variant R117G | Homo sapiens | L-phenylalanine | 0.02 | 0.012 | 1.7 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) variant R117G, L-phenylalanine |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS)variant R383C | Homo sapiens | tRNA^{Phe} | 0.145 | 0.0021 | 68 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) variant R383C, tRNA^{Phe} |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS)variant R387Q | Homo sapiens | tRNA^{Phe} | 0.18 | 0.0012 | 138 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) variant R387Q, tRNA^{Phe} |
| human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS)variant T210M | Homo sapiens | tRNA^{Phe} | 0.08 | 3.6 × 10⁻⁴ | 222 | pH 8.5, 37 °C | PMID 28419689 | Open record: human mitochondrial phenylalanyl-tRNA synthetase (HsmtPheRS) variant T210M, tRNA^{Phe} |
| TtPheRS (phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer) | Thermus thermophilus | 3,4-dihydroxy-L-phenylalanine | 0.162 | 0.38 | 0.43 | pH 8.5, 37 °C | PMID 22035791 | Open record: TtPheRS (phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer), 3,4-dihydroxy-L-phenylalanine |
| TtPheRS (phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer) | Thermus thermophilus | L-phenylalanine | 1.12 | 0.0017 | 650 | pH 8.5, 37 °C | PMID 22035791 | Open record: TtPheRS (phenylalanyl-tRNA synthetase, (alpha beta)2 heterotetramer), L-phenylalanine |