EC 6.3.2.8: UDP-N-acetylmuramate-L-alanine ligase
LigasesOpen in Browse
CatLog read 27 records for EC 6.3.2.8 from 2 papers, for 2 organisms. Names in these papers: UDP-N-acetylmuramate:L-alanine ligase (MurC), MurC ligase (UDP-MurNAc:L-Ala ligase).
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 34 records for EC 6.3.2.8 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 6.3.2.8 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Kinetic and crystallographic studies of Escherichia coli UDP-N-acetylmuramate:L-alanine ligase | Escherichia coli | 24 |
| Purification and biochemical characterization of Mur ligases from Staphylococcus aureus | Staphylococcus aureus | 3 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| MurC ligase (UDP-MurNAc:L-Ala ligase) | Staphylococcus aureus | adenosine 5'-triphosphate | — | 2 | — | pH 8.6, 37 °C | PMID 20659527 | Open record: MurC ligase (UDP-MurNAc:L-Ala ligase), adenosine 5'-triphosphate |
| MurC ligase (UDP-MurNAc:L-Ala ligase) | Staphylococcus aureus | L-alanine | — | 0.44 | — | pH 8.6, 37 °C | PMID 20659527 | Open record: MurC ligase (UDP-MurNAc:L-Ala ligase), L-alanine |
| MurC ligase (UDP-MurNAc:L-Ala ligase) | Staphylococcus aureus | UDP-N-acetylmuramic acid | — | 0.28 | — | pH 8.6, 37 °C | PMID 20659527 | Open record: MurC ligase (UDP-MurNAc:L-Ala ligase), UDP-N-acetylmuramic acid |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | (2S)-2-amino-N-(hydroxymethyl)propanamide | 11.7 | 16 | 0.72 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), (2S)-2-amino-N-(hydroxymethyl)propanamide |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | 1-(2-aminopropanoyl)piperidine | 6.2 | 62 | 0.092 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), 1-(2-aminopropanoyl)piperidine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | 2-aminobutanoic acid | 25 | 4.3 | 5.3 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), 2-aminobutanoic acid |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | adenosine 5'-triphosphatebiosynthetic ligase reaction (UNAM + ATP + L-alanine) | — | 0.13 | — | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), adenosine 5'-triphosphate |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | adenosine 5'-triphosphatecontinuous assay (ADP formation); cosubstrate UNAM | 0.53 | 0.022 | 24 calc. | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), adenosine 5'-triphosphate |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | DL-Propargylglycine | 20 | 1.1 | 18 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), DL-Propargylglycine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | Glycine | 22 | 10 | 2.3 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), Glycine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-alaninamide | 18 | 7.9 | 2.3 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-alaninamide |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-Alanine | 16.3 | 0.048 | 330 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-Alanine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-alanine benzyl ester | 13.5 | 0.36 | 27 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-alanine benzyl ester |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-alanine ethyl ester | 15.2 | 0.59 | 37 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-alanine ethyl ester |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-alanine methyl ester | 28 | 0.5 | 55 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-alanine methyl ester |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-alanine tert-butyl ester | 22 | 0.2 | 100 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-alanine tert-butyl ester |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-Cysteine | 20 | 3.8 | 5 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-Cysteine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-Isoleucine | 5.2 | 40 | 0.13 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-Isoleucine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-Serine | 25 | 1.2 | 20 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-Serine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-Threonine | 23 | 25 | 0.1 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-Threonine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-Valine | 22 | 70 | 0.28 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-Valine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | L-Vinylglycine | 15.3 | 0.44 | 35 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), L-Vinylglycine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | uridine diphosphate-N-acetylmuramatebiosynthetic ligase reaction (UNAM + ATP + L-alanine) | — | 0.044 | — | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), uridine diphosphate-N-acetylmuramate |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | uridine diphosphate-N-acetylmuramatecontinuous assay (ADP formation); cosubstrate ATP | — | 0.22 | — | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), uridine diphosphate-N-acetylmuramate |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | β-alanine | 2.5 | 0.046 | 0.92 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), β-alanine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | β-chloro-L-alanine | 20 | 0.14 | 150 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), β-chloro-L-alanine |
| UDP-N-acetylmuramate:L-alanine ligase (MurC) | Escherichia coli | β-cyano-L-alanine | 27 | 0.19 | 133 | pH 8, 37 °C | PMID 8976565 | Open record: UDP-N-acetylmuramate:L-alanine ligase (MurC), β-cyano-L-alanine |