Values CatLog read from this paper
Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates
PMID 12356303doi:10.1021/bi026092hOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 11 records (29 values) from this paper: ProFAR isomerase (HisA), phosphoribosylanthranilate isomerase (TrpF) from Thermotoga maritima, Escherichia coli.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| phosphoribosylanthranilate isomerase (TrpF)variant D126N | Thermotoga maritima | phosphoribosylanthranilate | — | 0.0021 | — | pH 7.5, 25 °C | Open record: phosphoribosylanthranilate isomerase (TrpF) variant D126N, phosphoribosylanthranilate |
| ProFAR isomerase (HisA) | Escherichia coli | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 4.9 | 0.0016 | 3.1 × 10³ | pH 7.5, 25 °C | Open record: ProFAR isomerase (HisA), N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA) | Escherichia coli | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 14.3 | 0.0018 | 7.9 × 10³ | pH 7.5, 37 °C | Open record: ProFAR isomerase (HisA), N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA) | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 0.67 | 6 × 10⁻⁴ | 1.1 × 10³ | pH 7.5, 25 °C | Open record: ProFAR isomerase (HisA), N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA) | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 1.54 | 6 × 10⁻⁴ | 2.6 × 10³ | pH 7.5, 37 °C | Open record: ProFAR isomerase (HisA), N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA) | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 32 | — | — | pH 7.5, 80 °C | Open record: ProFAR isomerase (HisA), N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA)variant D127N | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 2.7 × 10⁻⁴ | 0.002 | 0.13 | pH 7.5, 25 °C | Open record: ProFAR isomerase (HisA) variant D127N, N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA)variant D51N | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 0.29 | 0.0064 | 46 | pH 7.5, 25 °C | Open record: ProFAR isomerase (HisA) variant D51N, N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA)variant H48A | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 0.38 | 0.0029 | 131 | pH 7.5, 25 °C | Open record: ProFAR isomerase (HisA) variant H48A, N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA)variant R83N | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 0.23 | 0.0379 | 6 | pH 7.5, 25 °C | Open record: ProFAR isomerase (HisA) variant R83N, N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |
| ProFAR isomerase (HisA)variant T164A | Thermotoga maritima | N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide | 0.018 | 0.0056 | 3 | pH 7.5, 25 °C | Open record: ProFAR isomerase (HisA) variant T164A, N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide ribonucleotide |