Values CatLog read from this paper
Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and…
PMID 15797861doi:10.1074/jbc.m501269200Open in Browse
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CatLog read 17 records (46 values) from this paper: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1), human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) | Homo sapiens | 5-androstene-3,17-dione | 0.837 | — | 20.8 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1), 5-androstene-3,17-dione |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) | Homo sapiens | dehydroepiandrosterone | 0.055 | — | 14.8 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1), dehydroepiandrosterone |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) | Homo sapiens | NAD+ | 0.058 | — | 1.7 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1), NAD+ |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1)variant Q105M | Homo sapiens | 5-androstene-3,17-dione | 0.58 | 0.033 | 17.7 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) variant Q105M, 5-androstene-3,17-dione |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1)variant Q105M | Homo sapiens | dehydroepiandrosterone | 0.113 | 0.0405 | 2.8 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) variant Q105M, dehydroepiandrosterone |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1)variant Q105M | Homo sapiens | NAD+ | 0.038 | 0.0388 | 1 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) variant Q105M, NAD+ |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1)variant Q240R | Homo sapiens | 5-androstene-3,17-dione | 0.555 | 0.0623 | 8.8 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) variant Q240R, 5-androstene-3,17-dione |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1)variant Q240R | Homo sapiens | dehydroepiandrosterone | 0.023 | 0.0061 | 3.8 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) variant Q240R, dehydroepiandrosterone |
| human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1)variant Q240R | Homo sapiens | NAD+ | 0.022 | 0.0256 | 0.83 | pH 7.4, 27 °C | Open record: human type 1 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD1) variant Q240R, NAD+ |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) | Homo sapiens | 5-androstene-3,17-dione | 1.358 | — | 15.3 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2), 5-androstene-3,17-dione |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) | Homo sapiens | dehydroepiandrosterone | 0.118 | — | 2.5 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2), dehydroepiandrosterone |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2)variant Q105M | Homo sapiens | 5-androstene-3,17-dione | 1.112 | 0.0808 | 13.7 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) variant Q105M, 5-androstene-3,17-dione |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2)variant Q105M | Homo sapiens | dehydroepiandrosterone | 0.075 | 0.025 | 3 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) variant Q105M, dehydroepiandrosterone |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2)variant Q105M | Homo sapiens | NAD+ | 0.145 | 0.0614 | 2.3 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) variant Q105M, NAD+ |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2)variant R240Q | Homo sapiens | 5-androstene-3,17-dione | 0.573 | 0.0175 | 32.8 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) variant R240Q, 5-androstene-3,17-dione |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2)variant R240Q | Homo sapiens | dehydroepiandrosterone | 0.217 | 0.0327 | 6.7 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) variant R240Q, dehydroepiandrosterone |
| human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2)variant R240Q | Homo sapiens | NAD+ | 0.187 | 0.0372 | 5 | pH 7.4, 27 °C | Open record: human type 2 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD2) variant R240Q, NAD+ |