Values CatLog read from this paper
Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro
PMID 17451822doi:10.1016/j.molbiopara.2007.03.009Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 8 records (16 values) from this paper: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) from Plasmodium falciparum.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) | Plasmodium falciparum | 7,8-dihydrofolate | 1.24 | 0.0444 | 28 | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase), 7,8-dihydrofolate |
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) | Plasmodium falciparum | NADPH | — | 0.0232 | — | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase), NADPH |
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase)variant 51I/59R/108N | Plasmodium falciparum | 7,8-dihydrofolate | 1.23 | 0.0209 | 59 | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) variant 51I/59R/108N, 7,8-dihydrofolate |
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase)variant 51I/59R/108N | Plasmodium falciparum | NADPH | — | 0.0379 | — | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) variant 51I/59R/108N, NADPH |
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase)variant 51I/59R/108N/164L | Plasmodium falciparum | 7,8-dihydrofolate | 1.42 | 0.0207 | 69 | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) variant 51I/59R/108N/164L, 7,8-dihydrofolate |
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase)variant 51I/59R/108N/164L | Plasmodium falciparum | NADPH | — | 0.0373 | — | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) variant 51I/59R/108N/164L, NADPH |
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase)variant 51I/59R/108N/213A | Plasmodium falciparum | 7,8-dihydrofolate | 0.68 | 0.0102 | 66 | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) variant 51I/59R/108N/213A, 7,8-dihydrofolate |
| dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase)variant 51I/59R/108N/213A | Plasmodium falciparum | NADPH | — | 0.0309 | — | pH 7, 25 °C | Open record: dihydrofolate reductase (DHFR domain of the bifunctional DHFR-thymidylate synthase) variant 51I/59R/108N/213A, NADPH |