Values CatLog read from this paper
Reassessment of the reaction mechanism in the heme dioxygenases
PMID 19275153doi:10.1021/ja808326gOpen in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 5 records (10 values) from this paper: indoleamine 2,3-dioxygenase (hIDO), tryptophan 2,3-dioxygenase (XcTDO), tryptophan 2,3-dioxygenase (hTDO) from Homo sapiens, Xanthomonas campestris.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 5 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| indoleamine 2,3-dioxygenase (hIDO) | Homo sapiens | 1-methyl-L-tryptophan | 0.027 | 0.15 | 0.18 calc. | pH 8 | Open record: indoleamine 2,3-dioxygenase (hIDO), 1-methyl-L-tryptophan |
| indoleamine 2,3-dioxygenase (hIDO)variant S167A | Homo sapiens | 1-methyl-L-tryptophan | 0.032 | 0.031 | 1.0 calc. | pH 8 | Open record: indoleamine 2,3-dioxygenase (hIDO) variant S167A, 1-methyl-L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO)variant H76S | Homo sapiens | 1-methyl-L-tryptophan | 0.023 | 2.3 | 0.010 calc. | pH 8 | Open record: tryptophan 2,3-dioxygenase (hTDO) variant H76S, 1-methyl-L-tryptophan |
| tryptophan 2,3-dioxygenase (XcTDO)variant H55A | Xanthomonas campestris | 1-methyl-L-tryptophan | 0.048 | 0.059 | 0.81 calc. | pH 7.5 | Open record: tryptophan 2,3-dioxygenase (XcTDO) variant H55A, 1-methyl-L-tryptophan |
| tryptophan 2,3-dioxygenase (XcTDO)variant H55S | Xanthomonas campestris | 1-methyl-L-tryptophan | 0.052 | 0.07 | 0.74 calc. | pH 7.5 | Open record: tryptophan 2,3-dioxygenase (XcTDO) variant H55S, 1-methyl-L-tryptophan |