EC 1.13.11.11: tryptophan 2,3-dioxygenase
OxidoreductasesOpen in Browse
CatLog read 58 records for EC 1.13.11.11 from 8 papers, for 4 organisms. Names in these papers: tryptophan 2,3-dioxygenase, tryptophan 2,3-dioxygenase (hTDO), tryptophan 2,3-dioxygenase (TDO), tryptophan 2,3-dioxygenase (rhTDO) and 4 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 12 records for EC 1.13.11.11 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.13.11.11 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding | Xanthomonas campestris | 34 |
| Structural and functional analyses of human tryptophan 2,3-dioxygenase | Homo sapiens | 7 |
| Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase | Xanthomonas campestris | 5 |
| Chicken IDO2 and TDO2: Biochemical Characteristics and Regulatory Roles in Avian Tryptophan Metabolism and Inflammatory Response | Homo sapiens | 4 |
| A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase | Homo sapiens | 3 |
| Reassessment of the reaction mechanism in the heme dioxygenases | Homo sapiens, Xanthomonas campestris | 3 |
| NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria | Ralstonia metallidurans | 1 |
| Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes | Monosiga brevicollis | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| indoleamine 2,3-dioxygenase 1 (IDO1) | Homo sapiens | L-tryptophan | 8217 | 0.042 | 2.0 × 10⁵ calc. | pH 7.2, 37 °C | PMID 42791731 | Open record: indoleamine 2,3-dioxygenase 1 (IDO1), L-tryptophan |
| indoleamine 2,3-dioxygenase 1 (IDO1) | Homo sapiens | L-tryptophan | 5742 | 0.028 | 2.1 × 10⁵ calc. | pH 6.5, 37 °C | PMID 42791731 | Open record: indoleamine 2,3-dioxygenase 1 (IDO1), L-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | 5-methyl-DL-tryptophan | 3.59 | 0.357 | 10.1 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, 5-methyl-DL-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | 6-methyl-DL-tryptophan | 41 | 0.975 | 42 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, 6-methyl-DL-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | L-tryptophan | 19.7 | 0.256 | 77.0 calc. | pH 6, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, L-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | L-tryptophanapparent kcat | 21.7 | — | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, L-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | L-tryptophan | — | 0.162 | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, L-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | L-tryptophanapparent kcat | 19 | — | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, L-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | L-tryptophan | — | 0.089 | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, L-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | L-tryptophan | 21.6 | 0.121 | 179 calc. | pH 7, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, L-tryptophan |
| tryptophan 2,3-dioxygenase | Xanthomonas campestris | L-tryptophan | 18.3 | 0.0912 | 201 calc. | pH 8, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | 5-fluoro-DL-tryptophan | 0.68 | 0.194 | 3.5 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, 5-fluoro-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | 5-methyl-DL-tryptophan | 0.4 | 0.395 | 1.0 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, 5-methyl-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | 6-fluoro-DL-tryptophan | 3.78 | 0.195 | 19.4 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, 6-fluoro-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | 6-methyl-DL-tryptophan | 1.65 | 0.386 | 4.27 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, 6-methyl-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | dioxygen | 3.86 | 0.0457 | 84.5 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, dioxygen |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | L-tryptophan | 5.86 | 0.136 | 43.1 calc. | pH 6, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | L-tryptophanapparent kcat | 5.42 | — | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | L-tryptophan | — | 0.166 | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | L-tryptophanapparent kcat | 2.86 | — | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | L-tryptophan | — | 0.218 | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | L-tryptophan | 2.7 | 0.164 | 17 calc. | pH 8, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55A | Xanthomonas campestris | L-tryptophan | 4.69 | 0.213 | 22.0 calc. | pH 7, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | 5-fluoro-DL-tryptophan | 0.8 | 0.183 | 4.4 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, 5-fluoro-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | 5-methyl-DL-tryptophan | 1.45 | 1.302 | 1.11 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, 5-methyl-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | 6-fluoro-DL-tryptophan | 3.8 | 0.546 | 7.0 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, 6-fluoro-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | 6-methyl-DL-tryptophan | 4.66 | 1.98 | 2.35 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, 6-methyl-DL-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | dioxygen | 7.88 | 0.099 | 80 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, dioxygen |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophan | 2.6 | 0.197 | 13 calc. | pH 7.5, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophan | 4.91 | 0.3 | 16 calc. | pH 6, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophanapparent kcat | 3.66 | — | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophan | — | 0.23 | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophanapparent kcat | 2.1 | — | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophan | — | 0.121 | — | 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophan | 3.09 | 0.192 | 16.1 calc. | pH 7, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenasevariant H55S | Xanthomonas campestris | L-tryptophan | 2.28 | 0.134 | 17.0 calc. | pH 8, 25 °C | PMID 18783250 | Open record: tryptophan 2,3-dioxygenase variant H55S, L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO) | Homo sapiens | L-tryptophanfull-length hTDO (NP_005642) | 1.071 | 0.135 | 7.93 | pH 8, 25 °C | PMID 25066423 | Open record: tryptophan 2,3-dioxygenase (hTDO), L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO) | Homo sapiens | L-tryptophanresidues 19-388 (aa 19–388 truncation) | 0.976 | 0.153 | 6.38 | pH 8, 25 °C | PMID 25066423 | Open record: tryptophan 2,3-dioxygenase (hTDO), L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO)variant F140A | Homo sapiens | L-tryptophan | 0.032 | 1.531 | 0.02 | pH 8, 25 °C | PMID 25066423 | Open record: tryptophan 2,3-dioxygenase (hTDO) variant F140A, L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO)variant H76S | Homo sapiens | 1-methyl-L-tryptophan | 0.023 | 2.3 | 0.010 calc. | pH 8 | PMID 19275153 | Open record: tryptophan 2,3-dioxygenase (hTDO) variant H76S, 1-methyl-L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO)variant R144A | Homo sapiens | L-tryptophan | 0.045 | 0.631 | 0.07 | pH 8, 25 °C | PMID 25066423 | Open record: tryptophan 2,3-dioxygenase (hTDO) variant R144A, L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO)variant S151A | Homo sapiens | L-tryptophan | 0.105 | 0.146 | 0.72 | pH 8, 25 °C | PMID 25066423 | Open record: tryptophan 2,3-dioxygenase (hTDO) variant S151A, L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO)variant Y42A | Homo sapiens | L-tryptophan | 0.01 | 0.227 | 0.04 | pH 8, 25 °C | PMID 25066423 | Open record: tryptophan 2,3-dioxygenase (hTDO) variant Y42A, L-tryptophan |
| tryptophan 2,3-dioxygenase (hTDO)variant Y45A | Homo sapiens | L-tryptophan | 0.062 | 0.661 | 0.09 | pH 8, 25 °C | PMID 25066423 | Open record: tryptophan 2,3-dioxygenase (hTDO) variant Y45A, L-tryptophan |
| tryptophan 2,3-dioxygenase (rhTDO) | Homo sapiens | 5-fluoro-DL-tryptophan | 0.18 | 0.36 | 0.50 calc. | pH 8, 25 °C | PMID 18370401 | Open record: tryptophan 2,3-dioxygenase (rhTDO), 5-fluoro-DL-tryptophan |
| tryptophan 2,3-dioxygenase (rhTDO) | Homo sapiens | 5-methyl-DL-tryptophan | — | — | 0.1 | pH 8, 25 °C | PMID 18370401 | Open record: tryptophan 2,3-dioxygenase (rhTDO), 5-methyl-DL-tryptophan |
| tryptophan 2,3-dioxygenase (rhTDO) | Homo sapiens | L-tryptophan | 1.4 | 0.222 | 6.3 calc. | pH 8, 25 °C | PMID 18370401 | Open record: tryptophan 2,3-dioxygenase (rhTDO), L-tryptophan |
| tryptophan 2,3-dioxygenase (TDO) | Monosiga brevicollis | L-tryptophan | 8.513 | 0.2765 | 30.8 | pH 8, 37 °C | PMID 25702628 | Open record: tryptophan 2,3-dioxygenase (TDO), L-tryptophan |
| tryptophan 2,3-dioxygenase (TDO) | Xanthomonas campestris | 5-fluoro-DL-tryptophan | 2.4 | 0.1 | 24 calc. | pH 7.5, 25 °C | PMID 17197414 | Open record: tryptophan 2,3-dioxygenase (TDO), 5-fluoro-DL-tryptophan |
| tryptophan 2,3-dioxygenase (TDO) | Xanthomonas campestris | 6-fluoro-DL-tryptophan | 37.3 | 0.186 | 201 calc. | pH 7.5, 25 °C | PMID 17197414 | Open record: tryptophan 2,3-dioxygenase (TDO), 6-fluoro-DL-tryptophan |
| tryptophan 2,3-dioxygenase (TDO) | Xanthomonas campestris | dioxygen | 35.4 | 0.119 | 297 calc. | pH 7.5, 25 °C | PMID 17197414 | Open record: tryptophan 2,3-dioxygenase (TDO), dioxygen |
| tryptophan 2,3-dioxygenase (TDO) | Xanthomonas campestris | L-tryptophan | 19.5 | 0.114 | 171 calc. | pH 7.5, 25 °C | PMID 17197414 | Open record: tryptophan 2,3-dioxygenase (TDO), L-tryptophan |
| tryptophan 2,3-dioxygenase (TDO)variant H55A | Xanthomonas campestris | L-tryptophan | 2.86 | 0.133 | 21.5 calc. | pH 7.5, 25 °C | PMID 17197414 | Open record: tryptophan 2,3-dioxygenase (TDO) variant H55A, L-tryptophan |
| tryptophan 2,3-dioxygenase (TDO2) | Homo sapiens | L-tryptophan | 3003 | 0.02 | 1.5 × 10⁵ calc. | pH 7.2, 37 °C | PMID 42791731 | Open record: tryptophan 2,3-dioxygenase (TDO2), L-tryptophan |
| tryptophan 2,3-dioxygenase (TDO2) | Homo sapiens | L-tryptophan | 3184 | 0.03 | 1.1 × 10⁵ calc. | pH 6.5, 37 °C | PMID 42791731 | Open record: tryptophan 2,3-dioxygenase (TDO2), L-tryptophan |
| tryptophan 2,3-dioxygenase (XcTDO)variant H55A | Xanthomonas campestris | 1-methyl-L-tryptophan | 0.048 | 0.059 | 0.81 calc. | pH 7.5 | PMID 19275153 | Open record: tryptophan 2,3-dioxygenase (XcTDO) variant H55A, 1-methyl-L-tryptophan |
| tryptophan 2,3-dioxygenase (XcTDO)variant H55S | Xanthomonas campestris | 1-methyl-L-tryptophan | 0.052 | 0.07 | 0.74 calc. | pH 7.5 | PMID 19275153 | Open record: tryptophan 2,3-dioxygenase (XcTDO) variant H55S, 1-methyl-L-tryptophan |
| tryptophan-2,3-dioxygenase (TDO) | Ralstonia metallidurans | L-tryptophan | 22.6 | 0.35 | 64 | pH 7 | PMID 14700627 | Open record: tryptophan-2,3-dioxygenase (TDO), L-tryptophan |