CatLogenzyme kinetics catalog

EC 1.1.1.159: 7alpha-hydroxysteroid dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 20 records for EC 1.1.1.159 from 3 papers, for 2 organisms. Names in these papers: 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB), 7α-hydroxysteroid dehydrogenase (Ca7α-HSDH), 7α-hydroxysteroid dehydrogenase (CA 7α-HSDH).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 54 records for EC 1.1.1.159 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.159 in Browse.

Papers

PaperOrganismsRecords
Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization…Homo sapiens9
In search of sustainable chemical processes: cloning, recombinant expression, and functional characterization of the 7α- and 7β-hydroxysteroid dehydrogenases from Clostridium absonumClostridium absonum7
Enhanced activity and substrate tolerance of 7α-hydroxysteroid dehydrogenase by directed evolution for 7-ketolithocholic acid productionClostridium absonum4

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiens11-dehydrocorticosterone5 × 10⁻⁴0.00170.3pH 9.3, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiens3-hydroxybutyryl-CoA4.830.085257pH 9.3, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiens3α,7α-dihydroxy-5β-cholan-24-oic acid5.7 × 10⁻⁴0.03640.017pH 9.3, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiens3β,7β-dihydroxy-5β-cholan-24-oic acid9 × 10⁻⁴0.2190.0033pH 9.3, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiens5α-androstan-3α-ol-17-one6.7 × 10⁻⁴0.0410.017pH 9.3, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiens5α-pregnan-20β-ol-3-one0.00420.0050.88pH 9.3, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiensacetoacetyl-CoA23.80.0257927pH 7, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiensNAD+—0.0423—pH 9.3, 25 °CPMID 12917011Open
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10, ERAB)Homo sapiensNADH—0.0306—pH 7, 25 °CPMID 12917011Open
7α-hydroxysteroid dehydrogenase (CA 7α-HSDH)Clostridium absonumchenodeoxycholic acid2.340.066135.4pH 8, 25 °CPMID 30734123Open
7α-hydroxysteroid dehydrogenase (CA 7α-HSDH)Clostridium absonumnicotinamide adenine dinucleotide phosphate (oxidized form)3.660.311611.8pH 8, 25 °CPMID 30734123Open
7α-hydroxysteroid dehydrogenase (CA 7α-HSDH)variant Q255L/C260SClostridium absonumchenodeoxycholic acid210.0601349.4pH 8, 25 °CPMID 30734123Open
7α-hydroxysteroid dehydrogenase (CA 7α-HSDH)variant Q255L/C260SClostridium absonumnicotinamide adenine dinucleotide phosphate (oxidized form)18.450.1094168.6pH 8, 25 °CPMID 30734123Open
7α-hydroxysteroid dehydrogenase (Ca7α-HSDH)Clostridium absonum12-Ketochenodeoxycholic acid2.22 × 10⁵5.73.89 × 10⁴20 °CPMID 22198717Open
7α-hydroxysteroid dehydrogenase (Ca7α-HSDH)Clostridium absonum3α,12α-dihydroxy-7-oxo-5β-cholanoic acid1.36 × 10⁴0.961.42 × 10⁴20 °CPMID 22198717Open
7α-hydroxysteroid dehydrogenase (Ca7α-HSDH)Clostridium absonum3α,7α,12α-trihydroxy-5β-cholan-24-oic acid3.43 × 10⁵1.063.24 × 10⁵20 °CPMID 22198717Open
7α-hydroxysteroid dehydrogenase (Ca7α-HSDH)Clostridium absonum3α,7α-dihydroxy-5β-cholan-24-oic acid9.39 × 10³0.091.04 × 10⁵20 °CPMID 22198717Open
7α-hydroxysteroid dehydrogenase (Ca7α-HSDH)Clostridium absonum3α-Hydroxy-7,12-dioxo-5β-cholanoic acid3.06 × 10⁴1.142.68 × 10⁴20 °CPMID 22198717Open
7α-hydroxysteroid dehydrogenase (Ca7α-HSDH)Clostridium absonum7-ketolithocholic acid9770.137.52 × 10³20 °CPMID 22198717Open
7α-hydroxysteroid dehydrogenase (Ca7α-HSDH)Clostridium absonumDehydrocholic acid2.26 × 10⁴3.56.47 × 10³20 °CPMID 22198717Open