CatLogenzyme kinetics catalog

EC 1.14.16.4: tryptophan 5-monooxygenase

OxidoreductasesOpen in Browse

CatLog read 48 records for EC 1.14.16.4 from 5 papers, for 3 organisms. Names in these papers: tryptophan hydroxylase 2 (TPH2), tryptophan hydroxylase 1 (TPH1), tryptophan hydroxylase 1 catalytic domain (cTPH1), tryptophan hydroxylase (TrpH102–416).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 42 records for EC 1.14.16.4 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.14.16.4 in Browse.

Papers

PaperOrganismsRecords
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 bindingHomo sapiens20
Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2Homo sapiens12
Different properties of the central and peripheral forms of human tryptophan hydroxylaseHomo sapiens10
A simple two step procedure for purification of the catalytic domain of chicken tryptophan hydroxylase 1 in a form suitable for crystallizationGallus gallus4
Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylationOryctolagus cuniculus2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
tryptophan hydroxylase (TrpH102–416)Oryctolagus cuniculusL-phenylalaninetyrosine formation (A275); 0.2 mM 6-MePH4; 5 mM DTT2.12——pH 7, 25 °CPMID 16953590Open
tryptophan hydroxylase (TrpH102–416)Oryctolagus cuniculusL-phenylalanine6-MePH4 oxidation; 100-200 µM 6-MePH42.18——pH 7, 25 °CPMID 16953590Open
tryptophan hydroxylase 1 (TPH1)Homo sapiensL-phenylalanine—0.0344—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 1 (TPH1)Homo sapiensL-tryptophan—0.0106—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 1 (TPH1)Homo sapiensL-tryptophan—0.0228—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 1 (TPH1)Homo sapiensL-tryptophangel-filtered homogenate—0.0111—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 1 catalytic domain (cTPH1)Gallus gallus(6R)-5,6,7,8-tetrahydro-L-biopterinL-tryptophan 70 uM; O2 500 uM0.720.3242.2 calc.pH 7, 15 °CPMID 18055219Open
tryptophan hydroxylase 1 catalytic domain (cTPH1)Gallus gallus(6R)-5,6,7,8-tetrahydro-L-biopterinL-tryptophan 10 uM; O2 133 uM0.3270.0714.6 calc.pH 7, 15 °CPMID 18055219Open
tryptophan hydroxylase 1 catalytic domain (cTPH1)Gallus gallusdioxygen0.380.0399.7 calc.pH 7, 15 °CPMID 18055219Open
tryptophan hydroxylase 1 catalytic domain (cTPH1)Gallus gallusL-tryptophan0.530.007769 calc.pH 7, 15 °CPMID 18055219Open
tryptophan hydroxylase 2 (TPH2)Homo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin—0.0128—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 2 (TPH2)Homo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin—0.0202—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 2 (TPH2)Homo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin—0.0217—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)Homo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterinTEV-cleaved TPH2 (fusion partner removed)—0.0684—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-phenylalanine—0.284—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-tryptophan—0.0434—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-tryptophan—0.0403—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-tryptophangel-filtered homogenate—0.0131—pH 7, 30 °CPMID 15663479Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-tryptophan—0.0282—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-tryptophanTEV-cleaved TPH2 (fusion partner removed)—0.0413—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-tryptophan—0.0449—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)Homo sapiensL-tryptophanin buffer only (non-phosphorylated TPH2)—0.0545—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)Homo sapienstetrahydrobiopterin—0.0423—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)Homo sapienstetrahydrobiopterinin buffer only (non-phosphorylated TPH2)—0.0351—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant P449RHomo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin—0.0147—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant P449RHomo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterinTEV-cleaved TPH2 (fusion partner removed)—0.0518—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant P449RHomo sapiensL-tryptophan—0.0255—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant P449RHomo sapiensL-tryptophanTEV-cleaved TPH2 (fusion partner removed)—0.0511—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant R441HHomo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin—0.0149—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant R441HHomo sapiens(6R)-L-erythro-5,6,7,8-tetrahydrobiopterinTEV-cleaved TPH2 (fusion partner removed)—0.0289—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant R441HHomo sapiensL-tryptophan—0.0186—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant R441HHomo sapiensL-tryptophanTEV-cleaved TPH2 (fusion partner removed)—0.0334—pH 7, 30 °CPMID 17181551Open
tryptophan hydroxylase 2 (TPH2)variant S104AHomo sapiensL-tryptophan—0.0776—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S104AHomo sapiensL-tryptophanin buffer only (non-phosphorylated TPH2)—0.0618—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S104AHomo sapienstetrahydrobiopterin—0.175—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S104AHomo sapienstetrahydrobiopterinin buffer only (non-phosphorylated TPH2)—0.1514—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S104EHomo sapiensL-tryptophan—0.0786—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S104EHomo sapiensL-tryptophanin buffer only (non-phosphorylated TPH2)—0.0677—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S104EHomo sapienstetrahydrobiopterin—0.1628—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S104EHomo sapienstetrahydrobiopterinin buffer only (non-phosphorylated TPH2)—0.1488—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19AHomo sapiensL-tryptophan—0.1042—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19AHomo sapiensL-tryptophanin buffer only (non-phosphorylated TPH2)—0.0987—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19AHomo sapienstetrahydrobiopterin—0.0721—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19AHomo sapienstetrahydrobiopterinin buffer only (non-phosphorylated TPH2)—0.0797—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19EHomo sapiensL-tryptophan—0.0354—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19EHomo sapiensL-tryptophanin buffer only (non-phosphorylated TPH2)—0.0402—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19EHomo sapienstetrahydrobiopterin—0.0433—pH 7, 30 °CPMID 17973628Open
tryptophan hydroxylase 2 (TPH2)variant S19EHomo sapienstetrahydrobiopterinin buffer only (non-phosphorylated TPH2)—0.0577—pH 7, 30 °CPMID 17973628Open