EC 1.2.1.24: succinate-semialdehyde dehydrogenase (NAD+)

OxidoreductasesOpen in Browse

CatLog read 150 records for EC 1.2.1.24 from 9 papers, for 7 organisms. Names in these papers: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), succinate semialdehyde dehydrogenase YneI, aldehyde dehydrogenase, mitochondrial (ALDH2), succinic semialdehyde dehydrogenase (SSADH) and 5 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 25 records for EC 1.2.1.24 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.2.1.24 in Browse.

Papers

Papers with records for EC 1.2.1.24
Paper	Organisms	Records
Engineering an aldehyde dehydrogenase toward its substrates, 3-hydroxypropanal and NAD⁺, for enhancing the production of 3-hydroxypropionic acid	Azospirillum brasilense	61
Structure and activity of the NAD(P)+-dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium	Salmonella typhimurium	18
Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenase	Homo sapiens	16
Succinic semialdehyde dehydrogenase from the parasitic cattle tick Rhipicephalus microplus: gene identification, biochemical characterization and comparison with the mouse ortholog	Rhipicephalus microplus	15
A crucial active site network of titratable residues guides catalysis and NAD⁺ binding in human succinic semialdehyde dehydrogenase	Homo sapiens	12
Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-Hydroxypropionaldehyde as a substrate	Escherichia coli	10
Catalytic contribution of threonine 244 in human ALDH2	Homo sapiens	10
Unraveling the function of paralogs of the aldehyde dehydrogenase super family from Sulfolobus solfataricus	Sulfolobus solfataricus	6
Elucidation of the trigonelline degradation pathway reveals previously undescribed enzymes and metabolites	Acinetobacter baylyi	2

Records

Records for EC 1.2.1.24 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
aldehyde dehydrogenase, mitochondrial (ALDH2)	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	0.027	—	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2), nicotinamide adenine dinucleotide (oxidized)
aldehyde dehydrogenase, mitochondrial (ALDH2)	Homo sapiens	propanalTable I	3.2	5 × 10⁻⁴	6.3 × 10³ calc.	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2), propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)	Homo sapiens	propanalin the text	—	—	6.3 × 10³	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2), propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399D	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	0.078	—	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399D, nicotinamide adenine dinucleotide (oxidized)
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399D	Homo sapiens	propanal	1.6	4 × 10⁻⁴	4.0 × 10³ calc.	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399D, propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399H	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	0.21	—	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399H, nicotinamide adenine dinucleotide (oxidized)
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399H	Homo sapiens	propanalTable I	0.16	6 × 10⁻⁴	270 calc.	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399H, propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399H	Homo sapiens	propanalin the text	—	—	270	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399H, propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399K	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	0.34	—	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399K, nicotinamide adenine dinucleotide (oxidized)
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399K	Homo sapiens	propanal	0.017	9 × 10⁻⁴	19 calc.	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399K, propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399Q	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	0.12	—	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399Q, nicotinamide adenine dinucleotide (oxidized)
aldehyde dehydrogenase, mitochondrial (ALDH2)variant E399Q	Homo sapiens	propanal	0.33	3 × 10⁻⁴	1.1 × 10³ calc.	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant E399Q, propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192E	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	0.048	—	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant K192E, nicotinamide adenine dinucleotide (oxidized)
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192E	Homo sapiens	propanal	0.055	4 × 10⁻⁴	140 calc.	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant K192E, propanal
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192Q	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	3.6	—	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant K192Q, nicotinamide adenine dinucleotide (oxidized)
aldehyde dehydrogenase, mitochondrial (ALDH2)variant K192Q	Homo sapiens	propanal	0.58	0.0035	170 calc.	pH 7.4	PMID 9228057	Open record: aldehyde dehydrogenase, mitochondrial (ALDH2) variant K192Q, propanal
AldH (aldehyde dehydrogenase)	Escherichia coli	3-Hydroxypropionaldehyde4 mM NAD+; cosubstrate NAD+	28.54	0.49	58.57	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), 3-Hydroxypropionaldehyde
AldH (aldehyde dehydrogenase)	Escherichia coli	3-Hydroxypropionaldehyde4 mM NADP+; cosubstrate NADP+	4.91	0.29	16.92	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), 3-Hydroxypropionaldehyde
AldH (aldehyde dehydrogenase)	Escherichia coli	3-Hydroxypropionic acid	0.26	0.12	2.2	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), 3-Hydroxypropionic acid
AldH (aldehyde dehydrogenase)	Escherichia coli	Acetaldehyde	11.03	1	11.03	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), Acetaldehyde
AldH (aldehyde dehydrogenase)	Escherichia coli	Benzaldehyde	17.37	5.37	3.23	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), Benzaldehyde
AldH (aldehyde dehydrogenase)	Escherichia coli	Butyraldehyde	26.95	0.97	27.79	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), Butyraldehyde
AldH (aldehyde dehydrogenase)	Escherichia coli	Isovaleraldehyde	27.31	0.68	40.16	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), Isovaleraldehyde
AldH (aldehyde dehydrogenase)	Escherichia coli	NAD+	26.79	0.06	468.6	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), NAD+
AldH (aldehyde dehydrogenase)	Escherichia coli	Propionaldehyde	24.35	1.21	20.12	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), Propionaldehyde
AldH (aldehyde dehydrogenase)	Escherichia coli	Valeraldehyde	26.24	0.24	109.3	pH 8, 37 °C	PMID 18668238	Open record: AldH (aldehyde dehydrogenase), Valeraldehyde
ALDH2 (mitochondrial aldehyde dehydrogenase)	Homo sapiens	chloroacetaldehyde	7.7	0.039	200	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase), chloroacetaldehyde
ALDH2 (mitochondrial aldehyde dehydrogenase)	Homo sapiens	NAD+	—	0.048	158	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase), NAD+
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244A	Homo sapiens	chloroacetaldehyde	4	0.3	13.2	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244A, chloroacetaldehyde
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244A	Homo sapiens	NAD+	—	2.1	1.8	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244A, NAD+
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244G	Homo sapiens	chloroacetaldehyde	0.63	0.052	12.2	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244G, chloroacetaldehyde
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244G	Homo sapiens	NAD+	—	0.19	3.3	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244G, NAD+
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244S	Homo sapiens	chloroacetaldehyde	0.47	0.013	33	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244S, chloroacetaldehyde
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244S	Homo sapiens	NAD+	—	0.094	5	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244S, NAD+
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244V	Homo sapiens	chloroacetaldehyde	2.5	0.46	5.5	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244V, chloroacetaldehyde
ALDH2 (mitochondrial aldehyde dehydrogenase)variant T244V	Homo sapiens	NAD+	—	0.39	6.5	pH 7.4	PMID 23295226	Open record: ALDH2 (mitochondrial aldehyde dehydrogenase) variant T244V, NAD+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)	Azospirillum brasilense	3-hydroxypropanal	15	1.6	9	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)	Azospirillum brasilense	3-hydroxypropanal	15	1.6	9.4	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)	Azospirillum brasilense	3-hydroxypropanal	7.6	1.4	5.4	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)	Azospirillum brasilense	NAD^+	12	0.21	57	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)	Azospirillum brasilense	NAD^+	12	0.21	57	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)	Azospirillum brasilense	NAD^+	5.1	0.18	28	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)	Azospirillum brasilense	NADP^+	8.6	2.3	3.7	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase), NADP^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104	Azospirillum brasilense	3-hydroxypropanal	15	2.2	7	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104	Azospirillum brasilense	3-hydroxypropanal	7.5	1.6	4.7	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104	Azospirillum brasilense	NAD^+	19	0.28	68	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104	Azospirillum brasilense	NAD^+	7.9	0.23	34	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104-QR	Azospirillum brasilense	3-hydroxypropanal	6.7	0.43	16	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104-QR	Azospirillum brasilense	3-hydroxypropanal	3.7	0.4	9.3	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104-QR	Azospirillum brasilense	NAD^+	5.9	0.033	179	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104-QR	Azospirillum brasilense	NAD^+	3.1	0.031	100	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 104-QR	Azospirillum brasilense	NADP^+	4.7	0.7	6.8	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 104-QR, NADP^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106	Azospirillum brasilense	3-hydroxypropanal	12	1.4	9	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106	Azospirillum brasilense	3-hydroxypropanal	6.6	1.3	5.1	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106	Azospirillum brasilense	NAD^+	20	0.27	74	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106	Azospirillum brasilense	NAD^+	8.3	0.22	38	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106-QR	Azospirillum brasilense	3-hydroxypropanal	5	0.29	17	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106-QR	Azospirillum brasilense	3-hydroxypropanal	2.5	0.17	14	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106-QR	Azospirillum brasilense	NAD^+	4.8	0.025	192	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106-QR	Azospirillum brasilense	NAD^+	2.4	0.023	104	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 106-QR	Azospirillum brasilense	NADP^+	4	0.54	7.2	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 106-QR, NADP^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108	Azospirillum brasilense	3-hydroxypropanal	11	0.78	14	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108	Azospirillum brasilense	3-hydroxypropanal	5.9	0.87	6.8	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108	Azospirillum brasilense	NAD^+	18	0.27	67	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108	Azospirillum brasilense	NAD^+	7.9	0.26	30	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108-QR	Azospirillum brasilense	3-hydroxypropanal	6	0.17	35	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108-QR	Azospirillum brasilense	3-hydroxypropanal	3	0.14	21	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108-QR	Azospirillum brasilense	NAD^+	6.1	0.037	165	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108-QR	Azospirillum brasilense	NAD^+	2.9	0.028	104	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant 108-QR	Azospirillum brasilense	NADP^+	4.5	0.66	6.9	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant 108-QR, NADP^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant A110S	Azospirillum brasilense	3-hydroxypropanal	16	1.8	8.9	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant A110S, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant A110S	Azospirillum brasilense	NAD^+	10	0.2	50	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant A110S, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant A442P	Azospirillum brasilense	3-hydroxypropanal	18	1.8	10	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant A442P, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant A442P	Azospirillum brasilense	NAD^+	11	0.19	58	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant A442P, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant K273A	Azospirillum brasilense	3-hydroxypropanal	16	2	8	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant K273A, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant K273A	Azospirillum brasilense	NAD^+	12	0.16	75	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant K273A, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant K273E	Azospirillum brasilense	3-hydroxypropanal	14	1.6	8.8	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant K273E, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant K273E	Azospirillum brasilense	NAD^+	13	0.24	54	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant K273E, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant K273S	Azospirillum brasilense	3-hydroxypropanal	16	1.7	9.4	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant K273S, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant K273S	Azospirillum brasilense	NAD^+	11	0.16	69	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant K273S, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant N159V	Azospirillum brasilense	3-hydroxypropanal	11	6.8	1.6	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant N159V, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant N159V	Azospirillum brasilense	NAD^+	6	0.07	86	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant N159V, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant P444E	Azospirillum brasilense	3-hydroxypropanal	11	1.1	10	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant P444E, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant P444E	Azospirillum brasilense	NAD^+	10	0.17	59	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant P444E, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant P444T	Azospirillum brasilense	3-hydroxypropanal	18	1.7	11	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant P444T, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant P444T	Azospirillum brasilense	NAD^+	13	0.23	57	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant P444T, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant R281Q	Azospirillum brasilense	3-hydroxypropanal	13	1.3	10	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant R281Q, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant R281Q	Azospirillum brasilense	NAD^+	9	0.14	64	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant R281Q, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant T443D	Azospirillum brasilense	3-hydroxypropanal	15	1.2	13	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant T443D, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant T443D	Azospirillum brasilense	NAD^+	12	0.22	55	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant T443D, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant T443E	Azospirillum brasilense	3-hydroxypropanal	22	2.1	11	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant T443E, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant T443E	Azospirillum brasilense	NAD^+	16	0.28	57	25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant T443E, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant WT-QR	Azospirillum brasilense	3-hydroxypropanal	6.8	0.55	12	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant WT-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant WT-QR	Azospirillum brasilense	3-hydroxypropanal	2.4	0.29	8.3	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant WT-QR, 3-hydroxypropanal
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant WT-QR	Azospirillum brasilense	NAD^+	7.9	0.044	180	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant WT-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant WT-QR	Azospirillum brasilense	NAD^+	3.4	0.041	83	pH 6, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant WT-QR, NAD^+
KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase)variant WT-QR	Azospirillum brasilense	NADP^+	4.4	0.81	5.4	pH 8, 25 °C	PMID 29214999	Open record: KGSADH (alpha-ketoglutaric semialdehyde dehydrogenase) variant WT-QR, NADP^+
succinate semialdehyde dehydrogenase YneI	Salmonella typhimurium	NAD+	38	0.043	880	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI, NAD+
succinate semialdehyde dehydrogenase YneI	Salmonella typhimurium	NADP+	46	0.48	95	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI, NADP+
succinate semialdehyde dehydrogenase YneI	Salmonella typhimurium	succinate semialdehydefixed 2.0 mM NAD+ (Table II footnote b); cosubstrate NAD+	55	0.027	2 × 10³	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI, succinate semialdehyde
succinate semialdehyde dehydrogenase YneI	Salmonella typhimurium	succinate semialdehydefixed 6.0 mM NADP+ (Table II footnote c); cosubstrate NADP+	83	0.047	1.8 × 10³	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant D426A	Salmonella typhimurium	succinate semialdehyde	0.3	0.23	1.3	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant D426A, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant E442A	Salmonella typhimurium	succinate semialdehyde	164	0.14	1.1 × 10³	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant E442A, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant F138A	Salmonella typhimurium	succinate semialdehyde	26	0.12	210	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant F138A, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant K160A	Salmonella typhimurium	NAD+	39	10	3.8	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant K160A, NAD+
succinate semialdehyde dehydrogenase YneIvariant K160A	Salmonella typhimurium	NADP+	2.6	26	0.1	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant K160A, NADP+
succinate semialdehyde dehydrogenase YneIvariant K160E	Salmonella typhimurium	NAD+	80	11	7.3	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant K160E, NAD+
succinate semialdehyde dehydrogenase YneIvariant K160E	Salmonella typhimurium	NADP+	2.1	27	0.077	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant K160E, NADP+
succinate semialdehyde dehydrogenase YneIvariant K92A	Salmonella typhimurium	succinate semialdehyde	73	2.6	28	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant K92A, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant N193A	Salmonella typhimurium	NAD+	14	0.15	97	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant N193A, NAD+
succinate semialdehyde dehydrogenase YneIvariant N193A	Salmonella typhimurium	NADP+	21	2.4	8.6	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant N193A, NADP+
succinate semialdehyde dehydrogenase YneIvariant R145A	Salmonella typhimurium	succinate semialdehyde	45	2.49	18	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant R145A, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant R428A	Salmonella typhimurium	succinate semialdehyde	28	0.022	1.3 × 10³	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant R428A, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant S425A	Salmonella typhimurium	succinate semialdehyde	68	0.22	310	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant S425A, succinate semialdehyde
succinate semialdehyde dehydrogenase YneIvariant W141A	Salmonella typhimurium	succinate semialdehyde	66	0.77	86	pH 8	PMID 23229889	Open record: succinate semialdehyde dehydrogenase YneI variant W141A, succinate semialdehyde
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)subinhibitory SSA (1-10 μM); NAD+ varied	—	0.014	—	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), nicotinamide adenine dinucleotide (oxidized)
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)subinhibitory SSA (1-10 μM); full-range NAD+	—	0.036	—	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), nicotinamide adenine dinucleotide (oxidized)
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)inhibitory SSA (12-200 μM)	—	0.032	—	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), nicotinamide adenine dinucleotide (oxidized)
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)full-range SSA and NAD+	—	0.084	—	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), nicotinamide adenine dinucleotide (oxidized)
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	0.031	—	pH 8, 14 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), nicotinamide adenine dinucleotide (oxidized)
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)NAD+ varied at fixed 10 µM SSA; Michaelis-Menten fit (eq. 1)	68	0.032	2.1 × 10³ calc.	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), nicotinamide adenine dinucleotide (oxidized)
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	succinic semialdehydesubinhibitory SSA (1-10 μM); NAD+ varied	80	6 × 10⁻⁴	1.3 × 10⁵ calc.	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), succinic semialdehyde
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	succinic semialdehydesubinhibitory SSA (1-10 μM); full-range NAD+	87	0.0015	5.8 × 10⁴ calc.	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), succinic semialdehyde
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	succinic semialdehydeinhibitory SSA (12-200 μM)	165	—	—	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), succinic semialdehyde
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	succinic semialdehydefull-range SSA and NAD+	166	0.004	4.2 × 10⁴ calc.	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), succinic semialdehyde
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	succinic semialdehyde	26	0.0012	2.2 × 10⁴ calc.	pH 8, 14 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), succinic semialdehyde
succinic semialdehyde dehydrogenase (hSSADH)	Homo sapiens	succinic semialdehydeSSA varied at fixed 500 µM NAD+	124	0.005	2.5 × 10⁴ calc.	pH 8, 25 °C	PMID 39731543	Open record: succinic semialdehyde dehydrogenase (hSSADH), succinic semialdehyde
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	3-carboxybenzaldehyde	—	0.1418	21.8	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), 3-carboxybenzaldehyde
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	3-methylcarboxybenzaldehyde (methyl ester of 3-carboxybenzaldehyde)	—	0.1035	21	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), 3-methylcarboxybenzaldehyde (methyl ester of 3-carboxybenzaldehyde)
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	3-nitrobenzaldehyde	—	0.0502	35.1	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), 3-nitrobenzaldehyde
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	4-carboxybenzaldehyde	—	0.0312	120	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), 4-carboxybenzaldehyde
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	4-methylcarboxybenzaldehyde (methyl ester of 4-carboxybenzaldehyde)	—	0.1668	8.15	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), 4-methylcarboxybenzaldehyde (methyl ester of 4-carboxybenzaldehyde)
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	4-nitrobenzaldehyde	—	0.1612	11.5	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), 4-nitrobenzaldehyde
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	acetaldehyde	—	2.797	0.443	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), acetaldehyde
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	benzaldehyde	—	0.167	5.45	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), benzaldehyde
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	n-butanal	—	0.323	7.12	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), n-butanal
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	n-hexanal	—	0.107	28	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), n-hexanal
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	n-octanal	—	0.0514	52.1	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), n-octanal
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	n-pentanal	—	0.096	32.3	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), n-pentanal
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	NAD+	—	0.0433	28.3	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), NAD+
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	propanal	—	1.622	0.746	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), propanal
succinic semialdehyde dehydrogenase (SSADH)	Rhipicephalus microplus	succinic semialdehyde	—	0.00256	1.34 × 10³	pH 8.5, 22 °C	PMID 18588919	Open record: succinic semialdehyde dehydrogenase (SSADH), succinic semialdehyde
succinic semialdehyde dehydrogenase SSADH-I	Sulfolobus solfataricus	alpha-ketoglutaric semialdehyde (2,5-dioxopentanoate)	7.1	0.3	21.4	pH 6.5, 70 °C	PMID 23296511	Open record: succinic semialdehyde dehydrogenase SSADH-I, alpha-ketoglutaric semialdehyde (2,5-dioxopentanoate)
succinic semialdehyde dehydrogenase SSADH-I	Sulfolobus solfataricus	D,L-glyceraldehyde	0.7	2.6	0.3	pH 6.5, 70 °C	PMID 23296511	Open record: succinic semialdehyde dehydrogenase SSADH-I, D,L-glyceraldehyde
succinic semialdehyde dehydrogenase SSADH-I	Sulfolobus solfataricus	D,L-glyceraldehyde 3-phosphate	0.4	0.9	0.5	pH 6.5, 70 °C	PMID 23296511	Open record: succinic semialdehyde dehydrogenase SSADH-I, D,L-glyceraldehyde 3-phosphate
succinic semialdehyde dehydrogenase SSADH-I	Sulfolobus solfataricus	glycolaldehyde	0.4	2.8	0.1	pH 6.5, 70 °C	PMID 23296511	Open record: succinic semialdehyde dehydrogenase SSADH-I, glycolaldehyde
succinic semialdehyde dehydrogenase SSADH-I	Sulfolobus solfataricus	nicotinamide adenine dinucleotide (oxidized)	69	9.1	7.6	pH 6.5, 70 °C	PMID 23296511	Open record: succinic semialdehyde dehydrogenase SSADH-I, nicotinamide adenine dinucleotide (oxidized)
succinic semialdehyde dehydrogenase SSADH-I	Sulfolobus solfataricus	succinic semialdehyde	22.6	0.03	842	pH 6.5, 70 °C	PMID 23296511	Open record: succinic semialdehyde dehydrogenase SSADH-I, succinic semialdehyde
TgnE (succinate semialdehyde dehydrogenase)	Acinetobacter baylyi	NAD+	61.5	0.107	570		PMID 29686076	Open record: TgnE (succinate semialdehyde dehydrogenase), NAD+
TgnE (succinate semialdehyde dehydrogenase)	Acinetobacter baylyi	succinate semialdehyde	—	0.072	850		PMID 29686076	Open record: TgnE (succinate semialdehyde dehydrogenase), succinate semialdehyde