EC 2.1.1.56: mRNA (guanine-N7)-methyltransferase
TransferasesOpen in Browse
CatLog read 89 records for EC 2.1.1.56 from 5 papers, for 6 organisms. Names in these papers: NS2B-NS3 protease, nsp13 helicase, ΔNS2B-NS3pro (NS2B/NS3 protease complex), RNA-dependent RNA polymerase (nsp12/nsp8 complex) and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 29 records for EC 2.1.1.56 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 2.1.1.56 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies | West Nile virus | 71 |
| Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites | SARS-CoV-2 | 12 |
| Functional characterization of the NS2B/NS3 protease complex from seven viruses belonging to different groups inside the genus Flavivirus | Dengue virus type 3, Langat virus | 3 |
| Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency | Severe acute respiratory syndrome coronavirus | 2 |
| Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities | Homo sapiens | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| NS2B-NS3 protease | West Nile virus | 2-Naph-Lys-AcLys-Arg-pNA | 0.3 | 2.303 | 0.131 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-Naph-Lys-AcLys-Arg-pNA |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide | 0.96 | 0.0658 | 14.62 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide | 0.32 | 0.021 | 15.15 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-citrullyl-L-ornithyl-L-arginine para-nitroanilide | 0.57 | 0.1007 | 5.612 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-citrullyl-L-ornithyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide | 0.11 | 0.048 | 2.294 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide | 0.885 | 0.0434 | 20.38 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-lysyl-L-citrullyl-L-arginine para-nitroanilide | 0.43 | 3.423 | 0.127 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-citrullyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide | 0.59 | 0.0267 | 22.1 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 1.083 | 0.0254 | 42.60 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-lysyl-L-ornithyl-L-arginine para-nitroanilide | 1.58 | 0.0368 | 42.89 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-ornithyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide | 0.98 | 0.038 | 25.74 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | 2-naphthoyl-L-ornithyl-L-ornithyl-L-arginine para-nitroanilide | 0.27 | 0.0229 | 11.90 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, 2-naphthoyl-L-ornithyl-L-ornithyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-2-aminoisobutyryl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 1.6 | 0.0797 | 20.05 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-2-aminoisobutyryl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-2-aminooctanoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 2.51 | 0.0755 | 33.19 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-2-aminooctanoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-cyclohexylalanyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 2.28 | 0.0699 | 32.60 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-cyclohexylalanyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-cyclohexylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 1.78 | 0.0819 | 21.73 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-cyclohexylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide | 0.5 | 0.0887 | 5.601 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-4-amino-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide | 0.75 | 0.1413 | 5.306 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-4-amino-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-4-nitro-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide | 0.72 | 0.2541 | 2.817 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-4-nitro-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-4-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide | 0.9 | 0.2548 | 3.536 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-4-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide | 1.44 | 0.2086 | 6.904 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.266 | 0.199 | 1.332 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide | 1.18 | 0.0625 | 18.96 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide | 2.494 | 0.195 | 12.78 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 1.644 | 0.0546 | 30.12 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-leucyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide | 1.79 | 0.1055 | 17.00 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-norleucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 2.35 | 0.0807 | 29.09 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-norleucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-norvalyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 2.36 | 0.0673 | 35.00 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-norvalyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 protease | West Nile virus | N-acetyl-L-tert-butylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 1.74 | 0.1342 | 12.96 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease, N-acetyl-L-tert-butylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-L87A | West Nile virus | 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.0478 | 0.0884 | 0.541 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-L87A, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-L87A | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.07 | 0.434 | 0.161 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-L87A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-L87F | West Nile virus | 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.288 | 0.0369 | 7.796 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-L87F, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-L87F | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.228 | 0.764 | 0.299 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-L87F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-L87F | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 1.342 | 0.144 | 9.345 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-L87F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84A | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.126 | 0.376 | 0.336 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84D | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide | 0.398 | 0.0698 | 5.698 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84D, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84D | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 1.532 | 0.117 | 13.11 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84D, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84E | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide | 2.707 | 0.0664 | 40.80 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84E, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84E | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 3.027 | 0.0793 | 38.19 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84E, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84L | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.34 | 0.22 | 1.543 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84S | West Nile virus | 2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide | 0.151 | 0.0197 | 7.695 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84S, 2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84S | West Nile virus | 2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide | 0.027 | 0.0295 | 0.904 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84S, 2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84S | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide | 0.158 | 0.1 | 1.577 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84S, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-N84S | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.682 | 0.205 | 3.33 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-N84S, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-Q86A | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.127 | 1.203 | 0.105 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-Q86A, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-Q86A | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.367 | 0.258 | 1.424 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-Q86A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-Q86E | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.868 | 0.0777 | 11.18 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-Q86E, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-Q86L | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.973 | 0.148 | 6.586 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-Q86L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-V75A | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.164 | 5.318 | 0.031 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-V75A, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-V75A | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.173 | 0.199 | 0.866 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-V75A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-V75F | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.091 | 0.809 | 0.113 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-V75F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS2B-V75F | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.246 | 0.272 | 0.905 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS2B-V75F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-A164S | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.26 | 0.221 | 1.178 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-A164S, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-A164V | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.181 | 0.331 | 0.546 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-A164V, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-D129A | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.048 | 0.635 | 0.075 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-D129A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-D129E | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.036 | 0.432 | 0.083 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-D129E, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-I155F | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.733 | 0.207 | 3.532 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-I155F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-I162F | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.04 | 0.416 | 0.095 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-I162F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-I162F | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.164 | 0.268 | 0.612 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-I162F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-M156A | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.314 | 0.879 | 0.357 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-M156A, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-M156A | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.778 | 0.164 | 4.741 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-M156A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-T111F | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.051 | 0.376 | 0.135 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-T111F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-T111F | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.198 | 0.169 | 1.176 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-T111F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-T111L | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.018 | 0.617 | 0.03 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-T111L, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-T111L | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.06 | 0.214 | 0.279 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-T111L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-V154F | West Nile virus | 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.0431 | 0.0977 | 0.442 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-V154F, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-V154F | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.057 | 0.263 | 0.216 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-V154F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-V154L | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.245 | 0.344 | 0.712 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-V154L, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-V154L | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.8 | 0.19 | 4.223 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-V154L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-V166L | West Nile virus | N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide | 0.297 | 0.232 | 1.282 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-V166L, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide |
| NS2B-NS3 proteasevariant NS3-V166L | West Nile virus | N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide | 0.638 | 0.096 | 6.676 | pH 9.5, 37 °C | PMID 17052977 | Open record: NS2B-NS3 protease variant NS3-V166L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide |
| nsp13 helicase | SARS-CoV-2 | ATP100 nM labeled dsDNA | 1.4 | 0.122 | 13 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase, ATP |
| nsp13 helicase | SARS-CoV-2 | ATPunlabeled dsDNA present | 0.37 | 0.156 | 2.7 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase, ATP |
| nsp13 helicase | SARS-CoV-2 | dsDNA | 1.5 | 2.85 × 10⁻⁴ | 6 × 10³ | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase, dsDNA |
| nsp13 helicasevariant D534A | SARS-CoV-2 | ATP | 0.26 | 0.135 | 1.9 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant D534A, ATP |
| nsp13 helicasevariant L405D | SARS-CoV-2 | ATP | 0.9 | 0.118 | 10 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant L405D, ATP |
| nsp13 helicasevariant L405D | SARS-CoV-2 | dsDNA | 10 | — | 3 × 10³ | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant L405D, dsDNA |
| nsp13 helicasevariant S535A | SARS-CoV-2 | ATP100 nM labeled dsDNA | 2.8 | 0.094 | 30 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant S535A, ATP |
| nsp13 helicasevariant S535A | SARS-CoV-2 | ATPunlabeled dsDNA present | 0.47 | 0.176 | 2.7 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant S535A, ATP |
| nsp13 helicasevariant S535A | SARS-CoV-2 | dsDNA | 2.4 | 1.75 × 10⁻⁴ | 1.6 × 10⁴ | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant S535A, dsDNA |
| nsp13 helicasevariant T532A | SARS-CoV-2 | ATP100 nM labeled dsDNA | 2.9 | 0.121 | 24 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant T532A, ATP |
| nsp13 helicasevariant T532A | SARS-CoV-2 | ATPunlabeled dsDNA present | 0.61 | 0.126 | 5 | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant T532A, ATP |
| nsp13 helicasevariant T532A | SARS-CoV-2 | dsDNA | 3.7 | 2.82 × 10⁻⁴ | 1.4 × 10⁴ | pH 7.5, 37 °C | PMID 41581884 | Open record: nsp13 helicase variant T532A, dsDNA |
| RNA-dependent RNA polymerase (nsp12/nsp8 complex) | Severe acute respiratory syndrome coronavirus | adenosine 5'-triphosphate | — | 3 × 10⁻⁵ | — | pH 8, 30 °C | PMID 32284326 | Open record: RNA-dependent RNA polymerase (nsp12/nsp8 complex), adenosine 5'-triphosphate |
| RNA-dependent RNA polymerase (nsp12/nsp8 complex) | Severe acute respiratory syndrome coronavirus | remdesivir triphosphate | — | 1 × 10⁻⁵ | — | pH 8, 30 °C | PMID 32284326 | Open record: RNA-dependent RNA polymerase (nsp12/nsp8 complex), remdesivir triphosphate |
| RNMT (RNA guanine-N7 methyltransferase) | Homo sapiens | 5'-Gppp[A(2'-O-ribose methylated)]CCCCCCCCC-biotinylated 3' RNA | 0.0606 | — | — | PMID 41432309 | Open record: RNMT (RNA guanine-N7 methyltransferase), 5'-Gppp[A(2'-O-ribose methylated)]CCCCCCCCC-biotinylated 3' RNA | |
| ΔNS2B-NS3pro (NS2B/NS3 protease complex) | Dengue virus type 3 | t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide | 0.163 | 2.7 | 0.06 | pH 9, 37 °C | PMID 16504332 | Open record: ΔNS2B-NS3pro (NS2B/NS3 protease complex), t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide |
| ΔNS2B-NS3pro (NS2B/NS3 protease complex) | Dengue virus type 3 | t-butyloxycarbonyl-glycyl-L-lysyl-L-arginine 4-methylcoumaryl-7-amide | 0.007 | 0.181 | 0.034 | pH 9, 37 °C | PMID 16504332 | Open record: ΔNS2B-NS3pro (NS2B/NS3 protease complex), t-butyloxycarbonyl-glycyl-L-lysyl-L-arginine 4-methylcoumaryl-7-amide |
| ΔNS2B-NS3pro (NS2B/NS3 protease complex) | Langat virus | t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide | 0.007 | 0.324 | 0.02 | pH 9, 37 °C | PMID 16504332 | Open record: ΔNS2B-NS3pro (NS2B/NS3 protease complex), t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide |