CatLogenzyme kinetics catalog

Values CatLog read from this paper

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

PMID 32284326doi:10.1074/jbc.ra120.013679Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 17 records (17 values) from this paper: RNA-dependent RNA polymerase (nsp12/nsp8 complex), RNA-dependent RNA polymerase (L protein), RNA-dependent RNA polymerase (L protein/VP35 complex) from Severe acute respiratory syndrome coronavirus 2, Lassa virus, Ebola virus and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 2.1.1.56, EC 2.1.1.57, EC 2.7.7.48, EC 2.7.7.50, EC 3.4.19.12, EC 3.4.22.69, EC 3.6.4.12, EC 3.6.4.13

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
RNA-dependent RNA polymerase (L protein)Lassa virusadenosine 5'-triphosphate—1.1 × 10⁻⁴—pH 8, 30 °COpen
RNA-dependent RNA polymerase (L protein)Lassa virusremdesivir triphosphate—0.0013—pH 8, 30 °COpen
RNA-dependent RNA polymerase (L protein/VP35 complex)Ebola virusadenosine 5'-triphosphate—7.2 × 10⁻⁴—pH 8, 30 °COpen
RNA-dependent RNA polymerase (L protein/VP35 complex)Ebola virusremdesivir triphosphate—0.0025—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirusadenosine 5'-triphosphate—3 × 10⁻⁵—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirusremdesivir triphosphate—1 × 10⁻⁵—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 22'-C-methyladenosine 5'-triphosphate—0.0064—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 22'-deoxy-2'-alpha-fluoro-2'-beta-C-methyluridine 5'-triphosphate—0.021—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 22'-deoxy-2'-fluorocytidine 5'-triphosphate—2 × 10⁻⁵—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 22'-deoxyadenosine 5'-triphosphate—0.027—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 29-beta-D-arabinofuranosyladenine 5'-triphosphate—0.033—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 2adenosine 5'-triphosphate2 µM RNA template 3'-UGCGCUAGAAAAAAp—3 × 10⁻⁵—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 2adenosine 5'-triphosphate2 µM RNA template 3'-UGCGGUACUUUAUUp—4 × 10⁻⁵—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 2cytidine 5'-triphosphate—1 × 10⁻⁶—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 2favipiravir ribofuranosyl 5'-triphosphate—0.021—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 2remdesivir triphosphate—8.9 × 10⁻⁶—pH 8, 30 °COpen
RNA-dependent RNA polymerase (nsp12/nsp8 complex)Severe acute respiratory syndrome coronavirus 2uridine 5'-triphosphate—2 × 10⁻⁵—pH 8, 30 °COpen