EC 3.6.4.13: RNA helicase

HydrolasesOpen in Browse

CatLog read 135 records for EC 3.6.4.13 from 10 papers, for 9 organisms. Names in these papers: NS2B-NS3 protease, helicase-like domain of BaMV replicase, nsp13 helicase, DDX1 (DEAD-box RNA helicase), ATPase activity and 9 more.

EC 3.6.4.13 is no longer current; BRENDA: “transferred to EC 5.6.2.5, RNA 5'-3' helicase, EC 5.6.2.6, RNA 3'-5' helicase and EC 5.6.2.7, DEAD-box RNA helicase”.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 59 records for EC 3.6.4.13 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.6.4.13 in Browse.

Papers

Papers with records for EC 3.6.4.13
Paper	Organisms	Records
Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies	West Nile virus	71
Mutational analysis of a helicase motif-based RNA 5'-triphosphatase/NTPase from bamboo mosaic virus	Bamboo mosaic virus	12
Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites	SARS-CoV-2	12
A conserved phenylalanine of motif IV in superfamily 2 helicases is required for cooperative, ATP-dependent binding of RNA substrates in DEAD-box proteins	Saccharomyces cerevisiae	9
Substrate Specificities of DDX1: A Human DEAD-Box Protein	Homo sapiens	9
Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs	yeast	8
Differential RNA-dependent ATPase activities of four rRNA processing yeast DEAD-box proteins	Saccharomyces cerevisiae	8
Functional characterization of the NS2B/NS3 protease complex from seven viruses belonging to different groups inside the genus Flavivirus	Dengue virus type 3, Langat virus	3
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency	Severe acute respiratory syndrome coronavirus	2
The newly discovered Q motif of DEAD-box RNA helicases regulates RNA-binding and helicase activity	Saccharomyces cerevisiae	1

Records

Records for EC 3.6.4.13 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
Dbp3p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase; 25 mM KCl; coupled assay: 200 µM NADH	2.83	1.3	2.2 calc.	pH 7.5, 25 °C	PMID 18975973	Open record: Dbp3p, ATP
Dbp3p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase at high ionic strength: 110 mM KCl	—	1.7	—	pH 7.5, 25 °C	PMID 18975973	Open record: Dbp3p, ATP
Dbp4p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase; 25 mM KCl; coupled assay: 200 µM NADH	0.83	0.24	3.5 calc.	pH 7.5, 25 °C	PMID 18975973	Open record: Dbp4p, ATP
Dbp4p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase at high ionic strength: 110 mM KCl	—	0.39	—	pH 7.5, 25 °C	PMID 18975973	Open record: Dbp4p, ATP
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphatesingle-stranded 10-nucleotide RNA (ssRNA 10-mer)	0.2	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphatesingle-stranded 18-nucleotide RNA (ssRNA 18-mer)	0.25	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphatesingle-stranded 36-nucleotide RNA (ssRNA 36-mer)	0.2	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphate10-nucleotide poly(A) RNA	0.18	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphate10-nucleotide poly(C) RNA	0.2	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphate10-nucleotide poly(U) RNA	0.18	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphateblunt-ended dsRNA (36-mer ssRNA and its reverse complement)	0.3	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphatesingle-stranded 36-nucleotide DNA (ssDNA 36-mer)	0.083	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
DDX1 (DEAD-box RNA helicase), ATPase activity	Homo sapiens	adenosine 5'-triphosphateblunt-ended dsRNA/DNA hybrid	0.12	—	—	pH 8, 37 °C	PMID 39895751	Open record: DDX1 (DEAD-box RNA helicase), ATPase activity, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)	Saccharomyces cerevisiae	adenosine 5'-triphosphate	4.7	0.37	12.3	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase), adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant A457D	Saccharomyces cerevisiae	adenosine 5'-triphosphate	1.3	0.19	7	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant A457D, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant F405L	Saccharomyces cerevisiae	adenosine 5'-triphosphate	0.118	0.92	0.128	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant F405L, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant F405L/A457D	Saccharomyces cerevisiae	adenosine 5'-triphosphate	0.35	0.73	0.47	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant F405L/A457D, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant F405L/D479N	Saccharomyces cerevisiae	adenosine 5'-triphosphate	0.32	0.76	0.42	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant F405L/D479N, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant F405L/I348T	Saccharomyces cerevisiae	adenosine 5'-triphosphate	0.57	0.84	0.67	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant F405L/I348T, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant F405L/P174S	Saccharomyces cerevisiae	adenosine 5'-triphosphate	0.32	1.3	0.23	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant F405L/P174S, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant F405Y	Saccharomyces cerevisiae	adenosine 5'-triphosphate	0.55	0.5	1.1	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant F405Y, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase)variant I348T	Saccharomyces cerevisiae	adenosine 5'-triphosphate	2.83	0.069	41.7	30 °C	PMID 18332124	Open record: Ded1 (DEAD-box RNA helicase) variant I348T, adenosine 5'-triphosphate
Ded1 (DEAD-box RNA helicase, translation-initiation factor)variant F162A	Saccharomyces cerevisiae	adenosine 5'-triphosphate	0.33	3.5	0.093	pH 7.5, 30 °C	PMID 15201868	Open record: Ded1 (DEAD-box RNA helicase, translation-initiation factor) variant F162A, adenosine 5'-triphosphate
Has1p	yeast	adenosine 5'-triphosphate	0.09	0.44	0.20 calc.	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p, adenosine 5'-triphosphate
Has1pvariant H375E	yeast	adenosine 5'-triphosphate	0.07	0.92	0.076 calc.	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p variant H375E, adenosine 5'-triphosphate
Has1pvariant K389A	yeast	adenosine 5'-triphosphate	0.28	0.45	0.63 calc.	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p variant K389A, adenosine 5'-triphosphate
Has1pvariant K92A	yeast	adenosine 5'-triphosphate	0.0028	—	—	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p variant K92A, adenosine 5'-triphosphate
Has1pvariant K92A/K389A	yeast	adenosine 5'-triphosphate	0.012	—	—	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p variant K92A/K389A, adenosine 5'-triphosphate
Has1pvariant R376A	yeast	adenosine 5'-triphosphate	0.027	—	—	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p variant R376A, adenosine 5'-triphosphate
Has1pvariant S228A	yeast	adenosine 5'-triphosphate	0.063	0.76	0.083 calc.	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p variant S228A, adenosine 5'-triphosphate
Has1pvariant T230A	yeast	adenosine 5'-triphosphate	0.065	0.81	0.080 calc.	pH 6.5, 30 °C	PMID 15718299	Open record: Has1p variant T230A, adenosine 5'-triphosphate
helicase-like domain of BaMV replicase	Bamboo mosaic virus	5′-[γ-32P]RNA	0.075	0.059	1.3 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase, 5′-[γ-32P]RNA
helicase-like domain of BaMV replicase	Bamboo mosaic virus	ATP20 U pyruvate kinase; 20 U lactate dehydrogenase	—	—	450	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase, ATP
helicase-like domain of BaMV replicase	Bamboo mosaic virus	ATPpyruvate kinase and lactate dehydrogenase	67	0.15	450 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase, ATP
helicase-like domain of BaMV replicase	Bamboo mosaic virus	CTP	30	0.33	90	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase, CTP
helicase-like domain of BaMV replicase	Bamboo mosaic virus	GTP	35	0.21	170	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase, GTP
helicase-like domain of BaMV replicase	Bamboo mosaic virus	UTP	24	0.22	110	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase, UTP
helicase-like domain of BaMV replicasevariant D858A	Bamboo mosaic virus	5′-[γ-32P]RNA	0.02	0.22	0.091 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase variant D858A, 5′-[γ-32P]RNA
helicase-like domain of BaMV replicasevariant D858A	Bamboo mosaic virus	ATP	6.2	0.073	85 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase variant D858A, ATP
helicase-like domain of BaMV replicasevariant L543A	Bamboo mosaic virus	5′-[γ-32P]RNA	0.02	0.082	0.24 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase variant L543A, 5′-[γ-32P]RNA
helicase-like domain of BaMV replicasevariant L543A	Bamboo mosaic virus	ATP	4.6	0.15	31 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase variant L543A, ATP
helicase-like domain of BaMV replicasevariant Q826A	Bamboo mosaic virus	5′-[γ-32P]RNA	0.017	0.12	0.14 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase variant Q826A, 5′-[γ-32P]RNA
helicase-like domain of BaMV replicasevariant Q826A	Bamboo mosaic virus	ATP	0.73	0.0087	84 calc.	pH 7.5, 20 °C	PMID 17585982	Open record: helicase-like domain of BaMV replicase variant Q826A, ATP
NS2B-NS3 protease	West Nile virus	2-Naph-Lys-AcLys-Arg-pNA	0.3	2.303	0.131	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-Naph-Lys-AcLys-Arg-pNA
NS2B-NS3 protease	West Nile virus	2-naphthoyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide	0.96	0.0658	14.62	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide	0.32	0.021	15.15	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-citrullyl-L-ornithyl-L-arginine para-nitroanilide	0.57	0.1007	5.612	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-citrullyl-L-ornithyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide	0.11	0.048	2.294	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide	0.885	0.0434	20.38	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-lysyl-L-citrullyl-L-arginine para-nitroanilide	0.43	3.423	0.127	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-citrullyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide	0.59	0.0267	22.1	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	1.083	0.0254	42.60	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-lysyl-L-ornithyl-L-arginine para-nitroanilide	1.58	0.0368	42.89	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-lysyl-L-ornithyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide	0.98	0.038	25.74	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	2-naphthoyl-L-ornithyl-L-ornithyl-L-arginine para-nitroanilide	0.27	0.0229	11.90	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, 2-naphthoyl-L-ornithyl-L-ornithyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-2-aminoisobutyryl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	1.6	0.0797	20.05	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-2-aminoisobutyryl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-2-aminooctanoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	2.51	0.0755	33.19	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-2-aminooctanoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-cyclohexylalanyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	2.28	0.0699	32.60	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-cyclohexylalanyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-cyclohexylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	1.78	0.0819	21.73	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-cyclohexylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide	0.5	0.0887	5.601	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-3-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-4-amino-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide	0.75	0.1413	5.306	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-4-amino-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-4-nitro-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide	0.72	0.2541	2.817	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-4-nitro-L-phenylalanyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-4-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide	0.9	0.2548	3.536	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-4-pyridylalanyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide	1.44	0.2086	6.904	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-citrullyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.266	0.199	1.332	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide	1.18	0.0625	18.96	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-homoarginyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide	2.494	0.195	12.78	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	1.644	0.0546	30.12	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-leucyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide	1.79	0.1055	17.00	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-leucyl-L-ornithyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-norleucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	2.35	0.0807	29.09	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-norleucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-norvalyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	2.36	0.0673	35.00	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-norvalyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 protease	West Nile virus	N-acetyl-L-tert-butylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	1.74	0.1342	12.96	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease, N-acetyl-L-tert-butylglycyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-L87A	West Nile virus	2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.0478	0.0884	0.541	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-L87A, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-L87A	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.07	0.434	0.161	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-L87A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-L87F	West Nile virus	2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.288	0.0369	7.796	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-L87F, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-L87F	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.228	0.764	0.299	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-L87F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-L87F	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	1.342	0.144	9.345	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-L87F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84A	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.126	0.376	0.336	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84D	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide	0.398	0.0698	5.698	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84D, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84D	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	1.532	0.117	13.11	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84D, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84E	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide	2.707	0.0664	40.80	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84E, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84E	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	3.027	0.0793	38.19	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84E, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84L	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.34	0.22	1.543	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84S	West Nile virus	2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide	0.151	0.0197	7.695	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84S, 2-naphthoyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84S	West Nile virus	2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide	0.027	0.0295	0.904	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84S, 2-naphthoyl-L-lysyl-L-homoarginyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84S	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide	0.158	0.1	1.577	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84S, N-acetyl-L-leucyl-L-lysyl-L-arginyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-N84S	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.682	0.205	3.33	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-N84S, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-Q86A	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.127	1.203	0.105	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-Q86A, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-Q86A	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.367	0.258	1.424	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-Q86A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-Q86E	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.868	0.0777	11.18	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-Q86E, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-Q86L	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.973	0.148	6.586	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-Q86L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-V75A	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.164	5.318	0.031	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-V75A, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-V75A	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.173	0.199	0.866	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-V75A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-V75F	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.091	0.809	0.113	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-V75F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS2B-V75F	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.246	0.272	0.905	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS2B-V75F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-A164S	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.26	0.221	1.178	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-A164S, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-A164V	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.181	0.331	0.546	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-A164V, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-D129A	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.048	0.635	0.075	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-D129A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-D129E	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.036	0.432	0.083	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-D129E, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-I155F	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.733	0.207	3.532	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-I155F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-I162F	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.04	0.416	0.095	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-I162F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-I162F	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.164	0.268	0.612	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-I162F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-M156A	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.314	0.879	0.357	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-M156A, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-M156A	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.778	0.164	4.741	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-M156A, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-T111F	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.051	0.376	0.135	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-T111F, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-T111F	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.198	0.169	1.176	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-T111F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-T111L	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.018	0.617	0.03	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-T111L, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-T111L	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.06	0.214	0.279	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-T111L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-V154F	West Nile virus	2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.0431	0.0977	0.442	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-V154F, 2-naphthoyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-V154F	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.057	0.263	0.216	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-V154F, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-V154L	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.245	0.344	0.712	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-V154L, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-V154L	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.8	0.19	4.223	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-V154L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-V166L	West Nile virus	N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide	0.297	0.232	1.282	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-V166L, N-acetyl-L-leucyl-L-glutaminyl-L-tyrosyl-L-threonyl-L-lysyl-L-arginine para-nitroanilide
NS2B-NS3 proteasevariant NS3-V166L	West Nile virus	N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide	0.638	0.096	6.676	pH 9.5, 37 °C	PMID 17052977	Open record: NS2B-NS3 protease variant NS3-V166L, N-acetyl-L-leucyl-L-lysyl-L-lysyl-L-arginine para-nitroanilide
nsp13 helicase	SARS-CoV-2	ATP100 nM labeled dsDNA	1.4	0.122	13	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase, ATP
nsp13 helicase	SARS-CoV-2	ATPunlabeled dsDNA present	0.37	0.156	2.7	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase, ATP
nsp13 helicase	SARS-CoV-2	dsDNA	1.5	2.85 × 10⁻⁴	6 × 10³	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase, dsDNA
nsp13 helicasevariant D534A	SARS-CoV-2	ATP	0.26	0.135	1.9	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant D534A, ATP
nsp13 helicasevariant L405D	SARS-CoV-2	ATP	0.9	0.118	10	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant L405D, ATP
nsp13 helicasevariant L405D	SARS-CoV-2	dsDNA	10	—	3 × 10³	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant L405D, dsDNA
nsp13 helicasevariant S535A	SARS-CoV-2	ATP100 nM labeled dsDNA	2.8	0.094	30	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant S535A, ATP
nsp13 helicasevariant S535A	SARS-CoV-2	ATPunlabeled dsDNA present	0.47	0.176	2.7	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant S535A, ATP
nsp13 helicasevariant S535A	SARS-CoV-2	dsDNA	2.4	1.75 × 10⁻⁴	1.6 × 10⁴	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant S535A, dsDNA
nsp13 helicasevariant T532A	SARS-CoV-2	ATP100 nM labeled dsDNA	2.9	0.121	24	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant T532A, ATP
nsp13 helicasevariant T532A	SARS-CoV-2	ATPunlabeled dsDNA present	0.61	0.126	5	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant T532A, ATP
nsp13 helicasevariant T532A	SARS-CoV-2	dsDNA	3.7	2.82 × 10⁻⁴	1.4 × 10⁴	pH 7.5, 37 °C	PMID 41581884	Open record: nsp13 helicase variant T532A, dsDNA
RNA-dependent RNA polymerase (nsp12/nsp8 complex)	Severe acute respiratory syndrome coronavirus	adenosine 5'-triphosphate	—	3 × 10⁻⁵	—	pH 8, 30 °C	PMID 32284326	Open record: RNA-dependent RNA polymerase (nsp12/nsp8 complex), adenosine 5'-triphosphate
RNA-dependent RNA polymerase (nsp12/nsp8 complex)	Severe acute respiratory syndrome coronavirus	remdesivir triphosphate	—	1 × 10⁻⁵	—	pH 8, 30 °C	PMID 32284326	Open record: RNA-dependent RNA polymerase (nsp12/nsp8 complex), remdesivir triphosphate
Rok1p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase; 25 mM KCl; coupled assay: 200 µM NADH	0.25	1.1	0.23 calc.	pH 6.5, 25 °C	PMID 18975973	Open record: Rok1p, ATP
Rok1p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase at high ionic strength: 110 mM KCl	—	1.6	—	pH 6.5, 25 °C	PMID 18975973	Open record: Rok1p, ATP
Rrp3p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase; 25 mM KCl; coupled assay: 200 µM NADH	0.22	2.3	0.094 calc.	pH 7.5, 25 °C	PMID 18975973	Open record: Rrp3p, ATP
Rrp3p	Saccharomyces cerevisiae	ATPRNA-dependent ATPase at high ionic strength: 110 mM KCl	—	2.8	—	pH 7.5, 25 °C	PMID 18975973	Open record: Rrp3p, ATP
ΔNS2B-NS3pro (NS2B/NS3 protease complex)	Dengue virus type 3	t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide	0.163	2.7	0.06	pH 9, 37 °C	PMID 16504332	Open record: ΔNS2B-NS3pro (NS2B/NS3 protease complex), t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide
ΔNS2B-NS3pro (NS2B/NS3 protease complex)	Dengue virus type 3	t-butyloxycarbonyl-glycyl-L-lysyl-L-arginine 4-methylcoumaryl-7-amide	0.007	0.181	0.034	pH 9, 37 °C	PMID 16504332	Open record: ΔNS2B-NS3pro (NS2B/NS3 protease complex), t-butyloxycarbonyl-glycyl-L-lysyl-L-arginine 4-methylcoumaryl-7-amide
ΔNS2B-NS3pro (NS2B/NS3 protease complex)	Langat virus	t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide	0.007	0.324	0.02	pH 9, 37 °C	PMID 16504332	Open record: ΔNS2B-NS3pro (NS2B/NS3 protease complex), t-butyloxycarbonyl-glycyl-L-arginyl-L-arginine 4-methylcoumaryl-7-amide